42864 Results for: "ProSci Inc."
Anti-TRAF3IP1 Goat Polyclonal Antibody
Supplier: ProSci Inc.
Anti-TRAF3IP1 Goat Polyclonal Antibody
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Anti-HAX1 Goat Polyclonal Antibody
Supplier: ProSci Inc.
Anti-HAX1 Goat Polyclonal Antibody
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Anti-TMEM173 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
MPYS Antibody: MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.
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Anti-ADAMTS18 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
ADAMTS18 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
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Anti-CSNK2A2 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
CSNK2A2 belongs to the protein kinase superfamily, Ser/Thr protein kinase family, CK2 subfamily. It contains 1 protein kinase domain. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. CSNK2A2 participates in Wnt signaling. It phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.
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Anti-LRIT3 Mouse Monoclonal Antibody
Supplier: ProSci Inc.
Anti-LRIT3 Mouse Monoclonal Antibody
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Anti-TERF1 Mouse Monoclonal Antibody
Supplier: ProSci Inc.
Anti-TERF1 Mouse Monoclonal Antibody
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Anti-CR2 Mouse Monoclonal Antibody
Supplier: ProSci Inc.
Anti-CR2 Mouse Monoclonal Antibody
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Anti-MAP1B Mouse Monoclonal Antibody
Supplier: ProSci Inc.
Anti-MAP1B Mouse Monoclonal Antibody
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Anti-Troponin T type 2 Mouse Monoclonal Antibody
Supplier: ProSci Inc.
Anti-Troponin T type 2 Mouse Monoclonal Antibody
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Anti-TRPM7 Mouse Monoclonal Antibody
Supplier: ProSci Inc.
Anti-TRPM7 Mouse Monoclonal Antibody
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Anti-CXCL9 Mouse Monoclonal Antibody [clone: 1.1_2D3-2H3]
Supplier: ProSci Inc.
MIG, a member of the alpha-chemokine family (CXC) of cytokines, is produced by stimulated monocytes, macrophages and endothelial cells. It signals through the CXCR3 receptor.
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Anti-VEGFA Mouse Monoclonal Antibody [clone: 4B2-8]
Supplier: ProSci Inc.
Anti-VEGFA Mouse Monoclonal Antibody [clone: 4B2-8]
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Anti-CCL7 Mouse Monoclonal Antibody [clone: PEPY042_hMCP3]
Supplier: ProSci Inc.
MCP-3 is a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix.
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Human Recombinant 1Tim3 (from HEK293 cells)
Supplier: ProSci Inc.
Human Recombinant 1Tim3 (from HEK293 cells)
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Anti-ADRB3 Goat Polyclonal Antibody
Supplier: ProSci Inc.
Anti-ADRB3 Goat Polyclonal Antibody
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Anti-CXCL9 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
The function of CXCL9 has not been specifically defined; however, it is thought to be involved in T cell trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of cytokines.The function of this gene has not been specifically defined; however, it is thought to be involved in T cell trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of cytokines. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Anti-FOXM1 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
FOXM1 is a transcriptional activatory factor. It may play a role in the control of cell proliferation
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Anti-MAP3K1 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.
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Anti-HPGDS Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
PGDS is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Human recombinant syndecan 2 (from cells)
Supplier: ProSci Inc.
Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans have been reported and among them. Syndecan-2 plays a role in the cancer development. It can affect the basal and chemotherapy-induced apoptosis in osteosarcoma. It can also suppress MMP2 activation, suppressing metastasis.
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Human recombinant protocadherin 10 (from cells)
Supplier: ProSci Inc.
Protocadherin-10 (PCDH10) is a single-pass type I membrane protein that contains six extracellular cadherin domains, one transmembrane domain and one cytoplasmic tail differing from those of the classical cadherins. As a potential calcium-dependent cell-adhesion neuronal receptor, it may plays a role in the establishment and function of specific cell-cell connections in the brain. PCDH10 moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tested tissues.
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Human recombinant IL-20 R alpha (from cells)
Supplier: ProSci Inc.
Interleukin-20 Receptor Subunit alpha (IL20RA) is a single-pass type I membrane protein that is a member of the type II cytokine receptor family. IL20RA is synthetized a 553 amino acid glycoprotein precursor containing a 29 amino acid signal peptide, a 221 amino acid extracellular domain with two fibronectin type-III domains, a 24 amino acid transmembrane region, and a 279 amino acid intracellular domain. IL20RA is widely expressed with highest levels found in skin and testis and high levels in brain. IL20RA forms a heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26.
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Anti-CCND3 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
CCND3 encodes a protein that belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation.
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Anti-CDK8 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
The protein encoded by CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.
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Anti-RBX1 Rabbit Polyclonal Antibody
Supplier: ProSci Inc.
ROC1 encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.
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Anti-DDX5 Goat Polyclonal Antibody
Supplier: ProSci Inc.
Anti-DDX5 Goat Polyclonal Antibody
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Anti-LAG3 Mouse Monoclonal Antibody [clone: 17B4]
Supplier: ProSci Inc.
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
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Anti-LTBR Rat Monoclonal Antibody [clone: 4H8 WH2]
Supplier: ProSci Inc.
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
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Anti-DDX58 Mouse Monoclonal Antibody [clone: Alme-1]
Supplier: ProSci Inc.
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.