5269 Results for: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Cell permeable and potent angiogenesis inhibitor from the family of withanolides. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50=12nM) and in vivo. Exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits NF-κB activation by preventing the TNF-induced activation of IκB kinase β (IKKβ). Elicits IKKß hyperphosphorylation concomitant with inhibition of its kinase activity. Affects AP1 transcription and induces cell death. Alters cytoskeletal architecture by covalently binding annexin II and stimulating its basal F-actin cross-linking activity which inhibits the migratory and invasive capability of endothelial cells. Targets the intermediate filament protein vimentin. Displays neuronal regenerative properties. It induced significant regeneration of both axons and dendrites in an A β-induced axonal atrophy model.

Supplier: Enzo Life Sciences

For the quantitative determination of nitrite and nitrate levels in culture supernatants, plasma, serum, saliva, and urine from any species.

Supplier: Enzo Life Sciences

Irisin is a hormone that is involved in converting white adipose tissue into brown adipose tissue after physical exercise.

Supplier: Enzo Life Sciences

Hydrogen peroxide colorimetric detection kit provides a fast and higher throughput 96-well plate based homogeneous assay for the measurement of hydrogen peroxide in a wide variety of samples.

Supplier: Enzo Life Sciences

For the quantitative determination of hydrogen peroxide in culture supernatants and cell lysates from any species.

Supplier: Enzo Life Sciences

ASC (Apoptosis-associated speck-like protein containing a CARD domain) is a bipartite protein comprising two protein-protein interaction domains, a Pyrin domain (PYD) and a caspase recruitment domain (CARD). Proteins containing these domains play pivotal roles in regulating apoptosis and immune response pathways. Reported functions of ASC include apoptosis, activation of inflammatory caspases and regulation of NFκB.

Supplier: Enzo Life Sciences

MEK is a dual specificity kinase capable of phosphorylating both tyrosine and threonine residues. The MEK family, which is also known as MAP kinase kinase, phosphorylates MAP kinases on the conserved T-X-Y motif; phosphorylation of MAPK by MEK results in an increase in MAPK activity. MEK is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis.

Supplier: Enzo Life Sciences

HGF/SF (Hepatocyte growth factor/Scatter factor) is a multifunctional heterodimeric polypeptide. It mediates the growth and scattering of various cell types, epithelial mesenchymal transition, the formation of tubules and lumens, and promotes angiogenesis. The ligand-receptor pair has also shown to be uniquely involved in most human solid tumors and to participate in tumor development, invasion, and metastasis.

Supplier: Enzo Life Sciences

Interleukin-8 (IL-8) is a cytokine produced by monocytes, macrophages, neutrophils, lymphocytes, dermal fibroblasts, keratinocytes, vascular endothelial cells, melanocytes, hepatocytes and various tumor cell lines. It is also a member of the CXC family of chemokines, displaying chemotactic activity for neutrophils and T cells.

Supplier: Enzo Life Sciences

For the quantitative determination of β-Catenin in cell lysates of human, mouse, and rat origin.

Supplier: Enzo Life Sciences

Highly sensitive, rapid ELISA kit to quantify 5-hydroxymethylcytosine in DNA with results that closely correlate to mass spectrometry analysis.

Supplier: Enzo Life Sciences

The IL-12p70 (human) ELISA Kit is a colorimetric immunometric immunoassay kit for the quantitative determination of human IL-12p70 in culture supernatants, plasma, and serum samples.

Supplier: Enzo Life Sciences

Highly sensitive ELISA kit enabling detection of LTC4/D4/E4 in 4 hours.

Supplier: Enzo Life Sciences

The HSF1 EIA kit is a complete kit for the quantitative determination of HSF1 in cell lysates and tissue extracts from human and mouse origins. This is a Sensitive ELISA kit for this key transcription factor for heat shock protein (chaperone) research.

Supplier: Enzo Life Sciences

For the quantitative determination of progesterone in culture supernatants, serum, and saliva from any species. Cited sample type includes plasma.

Supplier: Enzo Life Sciences

The 5-Methylcytosine DNA ELISA kit is a complete, colorimetric, indirect immunoassay kit for the quantitative determination of 5-methylcytosine in DNA with results in less than three hours.

Supplier: Enzo Life Sciences

The Cortisol EIA kit is a colorimetric competitive enzyme immunoassay kit for the quantitative determination of cortisol in culture supernatants, plasma, serum, saliva, and urine from any species.

Supplier: Enzo Life Sciences

The opioid receptors δ, κ, and μ are members of the seven-transmembrane domain-containing receptor family of G-protein coupled receptors. δ- and μ-receptors serve as functional receptors for endogenous enkephalin and β-endorphin peptide ligands, respectively. δ-opioid receptors are highly expressed in the olfactory bulb, neocortex, caudate putamen and nucleus accumbens, with peripheral expression in the gastro-intestinal tract and vas deferens. δ-receptors inhibit neurotransmitter release resulting in a variety of biological effects including analgesia, motor integration, gastro-intestinal motility, olfaction, respiration, and memory. Neural μ-receptor expression is prominent in the caudate putamen, neocortex, thalamus, nucleus accumbens, hippocampus, and amygdala, as well as in peripheral nervous tissues in the gut. Named for its pharmacological mediation of analgesia by morphine, the μ receptor typically functions as a depressant in physiological processes including respiration, cardiovascular function, gastrointestinal motility, and thermoregulation.

Supplier: Enzo Life Sciences

The cannabinoid receptors CB1 (expressed primarily throughout the central nervous system) and CB2 (expressed in peripheral tissues) are members of the seven-transmembrane domain-containing family of G-protein coupled receptors (GPCRs), and are named for their signaling function in response to cannabinoid drugs such as delta-9-tetrahydrocannabinol (delta-9-THC). Significant evidence suggests that additional cannabinoid receptors may contribute to the many behavioral, vascular, and immunological effects of agonists such as THC and endogenous cannabinoids. Evidence suggests GPR55 may act as a cannabinoid receptor, although its definition as a bona fide "CB3" receptor remains controversial. GPR55 is highly expressed in large-diameter dorsal root ganglion (DRG) neurons, and its activation by cannabinoid compounds (THC, JWH015, and anandamide) has been shown to release calcium from IP3-sensitive ER stores. These findings are opposed by evidence that suggests GPR55 is an intrinsic receptor for lysophosphatidylinositol (LPI).

Supplier: Enzo Life Sciences

Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1), V1b (V3), and V2. V1b receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas. V2 receptors in the collecting ducts of the kidneys stimulate adenylyl cyclase activity, regulating the reabsorption of water via aquaporin channels.

Supplier: Enzo Life Sciences

Beclin-1 is a coiled-coil Bcl-2-interacting protein that functions in autophagy, the process of bulk degradation of cellular proteins. Beclin-1 is homologous to the yeast autophagy gene apg6, and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as both an anti-autophagic and anti-apoptotic protein.

Supplier: Enzo Life Sciences

The actions of the octapeptide circulatory hormone angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane domain-containing GPCR family. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II in cardiovascular homeostasis. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing.

Supplier: Enzo Life Sciences

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine found in the central nervous system, gastrointestinal tract, and blood with broad physiological functions as a neurotransmitter, in gastric motility, hemostasis, and cardiovascular integrity. Seven subclasses (5-HT 1-7) of serotonin receptors have been identified, a majority of which are members of the seven transmembrane domain-containing G-protein coupled receptor (GPCR) family, and are the target of several anti-depressant drugs. The 5-HT1 subclass consists of five highly homologous receptors that couple via G(i/o) alpha subunits to inhibit adenylyl cyclase activity. The 5-HT1A receptor gene is 99% homologous between human and mouse, and is expressed from an intronless gene with a predicted length of 421 amino acids. 5-HT1A receptor activation is generally inhibitory to cAMP production, but may also stimulate type II adenylyl cyclase activity in a cell-specific manner via release of G(beta/gamma) subunits when coupled to G(i2). 5-HT1A expression in mammals is strongest in CNS limbic pathways that control emotion, including tissue of the hippocampus, dorsal raphé, and septum.

Supplier: Enzo Life Sciences

Endothelins are vasoactive peptides that exist in three forms (ET-1, ET-2, and ET-3), and function in the maintenance of vascular tone via two identified seven transmembrane-spanning domain-containing G protein-coupled receptors (GPCR), endothelin A (ETA) and endothelin B (ETB). The human ETA receptor is primarily expressed in vascular smooth muscle cells, including those of the heart (also in myocytes), lung, and brain, and its stimulation generally results in vasoconstriction. Activation of ETA receptors can be stimulated by binding of ET-1 and ET-2, but not ET-3. triggering the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells. Human ETB receptors are primarily expressed in endothelial cells lining the vessel walls of the lungs, heart, and brain, and in contrast to ETA receptors, stimulation generally results in transient vasodilation. Activation of ETB receptors can be stimulated by binding of all three endothelins, triggering the release of vasorelaxive

Supplier: Enzo Life Sciences

The conversion of arachidonic acid to prostaglandin H2 (PGH2) by cyclooxygenase (COX) enzymes is the first step in the synthesis of prostanoids. Prostaglandin D2 (PGD2) is synthesized from PGH2 by the action of PGD synthase, and its actions in vasodilation and platelet activation are mediated via activation of two identified G-protein coupled receptors (GPCRs): DP1 and DP2 (formerly CRTH2). Both DP1 and DP2 receptors are coupled to Gs alpha subunits, resulting in increased adenylyl cyclase activity and cAMP production upon agonist binding. DP1 receptor is expressed moderately in the ileum and weakly in the lung, stomach, and uterus of mice, and weakly in the small intestine of humans. In rodents, expression of PGD synthase and the DP1 receptor is seen in the leptomeninges, where it is believed they play a role in the induction of sleep. The DP1 receptor may also oppose DP2-mediated activation of basophils, eosinophils, and Th2 cells.

Supplier: Enzo Life Sciences

The Big Endothelin-1 (Human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results overnight +1 hour.

Supplier: Enzo Life Sciences

Flat-bottom, half volume, 96-well assay plates.

Supplier: Enzo Life Sciences

This Leptin (Rat), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours. For the quantitative determination of rat leptin in culture supernatants, plasma, and serum.

Supplier: Enzo Life Sciences

Rapid DNA damage ELISA kit for cancer, apoptosis and oxidative stress.

Supplier: Enzo Life Sciences

Produced in E.coli.