5269 Results for: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Caspase and granzyme inhibitor

Supplier: Enzo Life Sciences

Caspase-6 substrate

Supplier: Enzo Life Sciences

Pepsin Porcine

Supplier: Enzo Life Sciences

The normal cross-reacting antigen (NCA) or CEACAM6 belongs to the carcinoembryonic antigen (CEA) gene family. CEACAM6 is a GPI-anchored membrane protein with a single N domain, which shows structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like domains.

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2a

Supplier: Enzo Life Sciences

Inhibitor of PI3Kγ, PI3Kδ, FRAP, Akt and VEGF.

Supplier: Enzo Life Sciences

Potent and selective inhibitor of mammalian Plk1

Supplier: Enzo Life Sciences

Cell-permeable and selective inhibitor of the ubiquitin-conjugating (E2) enzyme Ubc13-Uev1A.

Supplier: Enzo Life Sciences

PLA2 stimulatory bee venom peptide. Sequence is similar to Phospholipase A2 Activating Peptide (Prod. No. ALX-165-007). Activates PLA2 (5-fold at 10 µg/ml) in BC3H1 cells. For additional technical information see melittin (natural) (Prod. No. ALX-162-006).

Supplier: Enzo Life Sciences

MMP-8 is a glycoprotein containing complex N-linked oligosaccharides.

Supplier: Enzo Life Sciences

Food intake modulator

Supplier: Enzo Life Sciences

Produced in E. coli. Homologous to human serum leptin.

Supplier: Enzo Life Sciences

The IL-10 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit kor the quantitative determination of human IL-10 in culture supernatants, plasma, and serum.

Supplier: Enzo Life Sciences

The most sensitive, specific and flexible alternative to more costly and time-consuming methods for oxytocin detection.

Supplier: Enzo Life Sciences

For the quantitative determination of IgG2b in culture supernatants and serum of mouse origin.

Supplier: Enzo Life Sciences

The Glutathione Peroxidase activity kit is a convenient 96-well plate based assay for the higher throughput analysis of glutathione peroxidase activity in a variety of sample matrices in just 30 minutes.

Supplier: Enzo Life Sciences

The IHC PAP pen provides a hydrophobic barrier when a circle is drawn around a specimen on a glass slide.

Supplier: Enzo Life Sciences

For the quantitative determination of αB-Crystallin in cell lysates of human, mouse, rat, and cow origin.

Supplier: Enzo Life Sciences

For the quantitative determination of PDI in cell lysates, culture supernatants, plasma, and tissue of human, mouse, and rat origin.

Supplier: Enzo Life Sciences

Ultra-sensitive (7 pg/ml)Amp'd® HSP70 high sensitivity ELISA kit enabling the ability to use less sample and detect both baseline and upregulated levels of human, mouse and rat Hsp70 (Hsp72), a major chaperone, cancer biomarker, and key cell stress regulator.

Supplier: Enzo Life Sciences

AMPIGENE® cDNA Synthesis Kit for efficient and sensitive cDNA synthesis, for downstream qPCR.

Supplier: Enzo Life Sciences

Highly reproducible SA-β-gal activity kit

Supplier: Enzo Life Sciences

Highly sensitive IL-5 ELISA kit enabling detection of IL-5 in serum, plasma, urine and cell culture supernates in just 3 hours.

Supplier: Enzo Life Sciences

The Ras superfamily of small guanosine triphosphatases (GTPases) is traditionally subdivided into five families: Ras, Rho, Rab, Ran, and Arf. Rap1/Krev1 is a member of the Ras family of low molecular weight GTP-binding proteins1. Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1 is primarily found at the cytosolic side of intracellular membranes and has two isoforms: Rap1a and 1b2. Both isoforms have a molecular mass of 21 kDa and are isoprenylated at the carboxyl-terminal and phosphorylated by the cAMP-dependent protein kinase A (PKA)3. Rap1 cycles between a GTP-bound active form and a GDP-bound inactive form that is mediated by GTPase activating protein (GAP) and GDP dissociation stimulator (GDS)4,5. Activation occurs by a variety of extracellular stimuli through several conserved guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 is proposed to regulate Ras mediated signaling and may also be involved in the regulation of integrinmediated cell adhesion, although the mechanism of regulation is not known. Overexpression of Rap reverses the transformed phenotype induced by Ras, possibly by competing with Ras for interaction with Ras-GAP. Rap has been shown to participate in MAP kinase cascade activated by growth factor and maintaining human T cell anergic state by blocking IL-2 expression.

Supplier: Enzo Life Sciences

The casein kinases are serine/threonine protein kinases involved in the regulation of multiple cell signaling pathways. There are at least seven identified mammalian isoforms in the casein kinase I (CKI) family, which are monomeric and function in cell growth and the replication and repair of DNA. Casein kinase II (CK2) is a ubiquitous tetrameric holoenzyme comprised of two catalytic alpha subunits and two regulatory beta subunits. CK2 enzymes are known to regulate metabolic signal transduction, transcription, and translation.

Supplier: Enzo Life Sciences

Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.

Supplier: Enzo Life Sciences

Vimentin is one of four type II intermediate filament (IF) proteins; Desmin, Glial fibrillary acidic protein (GFAP) and Peripherin being the others. Vimentin is the most widely distributed of all IF proteins. It is typically expressed in leukocytes, blood vessel endothelial cells, and mesenchymal cells such as fibroblasts. Vimentin filaments help support cellular membranes. Vimentin networks also may help keep the nucleus and other organelles in a defined place within the cell.

Supplier: Enzo Life Sciences

Optimised dye-based qPCR.

Supplier: Enzo Life Sciences

Sensitive BNP fragment ELISA kit enabling detection of BNP fragment in serum and plasma.

Supplier: Enzo Life Sciences

The Screen-Well® myotoxicity library is a focused collection of 60 compounds with defined and diverse myotoxicity, including rhabdomyolysis, cardiomyopathy, mitrochondrial myopathy, vacuolar myopathy, and more. A variety of structurally and mechanistically different compound classes are included, as well as non toxic controls. All compounds are dissolved in DMSO at 10 mM unless otherwise stated in the documentation provided with the library. Selected compounds are dissolved in DI water. All compounds are provided at 100 µl volumes in a 96-Well plate.