Supplier: ENZO LIFE SCIENCES

Fluorogenic substrate for furin/SPC1/PACE/PCSK3 and other subtilisin/kexin-like proprotein convertases such as Kex2, SPC2/PC2/PCSK2, SPC3/PCSK1, PACE4/SPC4/PCSK6, SPC5/PC4/PCSK4, SPC6/PC5/PC6/PCSK5, and SPC7/LPC/PC7/PC8/PCSK7. Can be used on live cells. Ex: 340-360 nm, Em: 440-460 nm.

Supplier: ENZO LIFE SCIENCES

Blocks methyl esterification of geranylgeranylated proteins

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Host: Mouse, Isotype: IgG1

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Produced in E. coli.

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Recommended Applications: ELISA, IP, WB

Species reactivity: Human, Mouse

Supplier: ENZO LIFE SCIENCES

Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing G-protein coupled receptor (GPCR) family A, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 dopamine receptors are encoded by homologous intron-containing genes, and signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity, as well as modulate cellular ion channel conductance of K+ and Ca2+. This is in contrast to D1 and D5 dopamine receptors, which signal via Gs alpha subunits to activate adenylyl cyclase activity. Coactivation of D1 and D2 receptors has been shown to activate a Gq mediated pathway, stimulating phospholipase C (PLC) and mobilizing intracellular calcium stores. D1 receptors were initially characterized in the striatum and retina and are expressed throughout the brain in the olfactory tubercle, islands of Calleja, entopeduncular nucleus, neocortex, hippocampus, and amygdala. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.

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A potent and selective inhibitor of α-L-fucosidases.

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Produced in SF21 cells. Fused to a His-tag.

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Produced in E. coli.

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Cytochalasin D is a cell-permeable fungal toxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. It causes the disruption of actin filaments and inhibition of actin polymerization. It is about 10-fold more effective than cytochalasin B and does not inhibit monosaccharide transport across cell membranes. Inactivates low conductance K+ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Induces apoptosis.

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Circulating metabolite of PGE1 in man. Vasodilator equipotent with PGE12. Inhibits human platelet aggregation. Antimitotic activity.

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The assembly of individual mammalian proteasome subunits into catalytically active 20S proteasome is a complex process, with biogenesis of the mammalian 20S proteasome occuring via precursor complexes containing α and unprocessed β subunits. The pro-peptides of the β subunits are thought to prevent premature conversion of the precursor complexes into matured particles and are needed for efficient β subunit incorporation. The complex biogenesis is tightly regulated, requiring additional components such as the maturation factor POMP (proteasome maturation protein), an ubiquitous protein in eukaryotic cells. Mammalian POMP is functionally related to but not interchangable with its yeast homologue Ump1. POMP is associated purely with the precursor intermediates and is degraded upon final maturation. Northern blot experiments have revealed that expression of POMP is induced after treatment with interferon γ.

Supplier: ENZO LIFE SCIENCES

Host: Mouse, Isotype: IgG2b

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Produced in E. coli. Human iNOS is fused to an N-terminal His-tag.

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Completely inhibits PLA2 activation following cryogenic brain injury in the rabbit at 200 mg/kg. Intermediate in phospholipid biosynthesis.

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HDAC inhibitor

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Glutamate receptor ligand

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Most efficient spin trap for the in vitro and in vivo detection of O-, N-, S-, and C-centered free radicals.

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Host: Mouse, Isotype: IgG1

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Highly sensitive ELISA, measuring DHEA in culture supernatants, plasma, serum, saliva, and urine from any species.

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Ecdysteroid.

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mGluR5 antagonist.

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The CD14 glycoprotein, gp 55, is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 molecule has been reported to be a receptor for endotoxin.

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Sensitive (10 ng/ml) ELISA for the quantitative determination of host cell protein contamination in bulk products expressed in Chinese Hamster Ovary (CHO) expression systems.

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Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development.

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Produced in E. coli. Full length human NMNAT3 is fused at the N-terminus to a His-tag.

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Host: Rabbit

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Host: Human, Isotype: IgG1

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Produced in E. coli. Human SUMO-2 is fused to a His-tag.

Supplier: ENZO LIFE SCIENCES

Produced in E.coli.