5268 Results for: "ENZO LIFE SCIENCES"

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Host: Mouse, Isotype: IgG2b

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Host: Rat, Isotype: IgG2a

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A QuantiZyme™ Assay System. The MMP-1 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-1 (MMP-1, interstitial collagenase) using a quenched fluorogenic peptide: OmniMMP™ fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties.

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PKC activator.

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A potent and selective vanilloid receptor (TRPV1) antagonist. An effective antagonist of hTRPV1 when stimulated by capsaicin, acid, or noxious heat.

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The Hsp70 family of heat shock proteins contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

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Small molecule inducer of autophagy important for neurodegenerative disease research.

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Fas ligand

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Retinoid X receptor ligand.

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Fluorogenic substrate for ADAM8 (kcat/Km = 1,0×105 M-1s-1), ADAM10 (6,2×103), ADAM12 (2,8×105), TACE (TNF-α converting enzyme, ADAM17) (4,3×105), and likely other ADAMs, especially those that cleave TNF-α type sequences. Also efficiently cleaved by MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, and MMP-14. FAM fluorescence is quenched by the Dabcyl group until cleavage separates them. Ex.: 485 nm, Em.: 530 nm. This substrate is useful for inhibitor screening and kinetic analysis.

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The chromatin non-histone high mobility group of proteins (HMG)-1 and -2 contain conserved domains known as HMG-boxes. Both HMG-1 and HMG-2 contain an N-terminal HMG box, a central HMG box and an acidic carboxy terminus.

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Fixation, (buffer)

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DGAT inhibitor

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Nuclear factor kappa-B (NFk) B) functions as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NF-kB is a heterodimer consisting of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA) (ref. 3), both of which exhibit sequence homology to the protooncogene c-Rel. p50 has an isoform called p49/p52, and both proteins derive from the amino-terminal of precursor protein p105 and p100, respectively. The p50/p65 heterodimer remains in inactive form in the cytosol as a complex with its inhibitor, IkB. Upon stimulation of cells by a variety of stimuli, including lipopolysaccharide (LPS), pro-inflammatory cytokines like interleukin-1 and tumor necrosis factor, and viral infection, IkB becomes phosphorylated and degraded by the proteosome. The active NF-kB heterodimer translocates into the nucleus and induces gene expression.

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eNOS activator

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PLD inhibitor.

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Anti-EIF2 alpha Rabbit Polyclonal Antibody

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PLD inhibitor

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MMP inhibitor

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Prostanoid receptor ligand.

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Host: Rabbit

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Blm10 (mammalian homolog PA200) is a large 246kDa regulatory protein that binds to the 20S proteasome core particle (CP). Blm10 recognizes pre-activated open gate CP which is assumed to exist in equilibrium with inactive closed gate CP. Blm10 distinguishes gate conformations, regulates CP activation, and has been shown to be involved in CP maturation.

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Produced in E. coli. Human αB-Crystallin is fused at the N-terminus to a His-tag.

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CDK1 inhibitor

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Chemopreventive agent

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The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

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Produced in E.coli.

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Inactive mastoparan analog.

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Tyrosinase inhibitor

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Active carboxylate form of Lovastatin. Active in whole cells as well as cell-free assays. Inhibits cholesterol/ isoprenoid biosynthesis by inhibition of HMG-CoA reductase (Ki for acid form is 1 nM) and blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Causes cells to arrest early in the G1 phase.