5268 Results for: "ENZO LIFE SCIENCES"

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Cathepsin inhibitor

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3-Aminobenzamide

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PKC inhibitor

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Dihydrocapsaicin

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Olomoucine is a purine derivative which acts as a potent and selective inhibitor of CDK1 (p34cdc2)/cyclin B and related kinases. It acts by competing for the ATP binding domain of the kinase. Of 35 protein kinases tested, olomoucine inhibited p33CDK2/cyclin A, p33CDK2/cyclin E, p34cdc2/cyclin B, p33CDK5/p35 and erk1 with IC50 of 7, 7, 7, 3 and 25µM respectively. The related kinases p34CDK4/cyclin D and p40CDK6/cyclin D3 were not inhibited or were less sensitive to olomoucine, IC50 > 1000 and 250µM respectively. PKC, PKA, PKG, CaM kinase II, MLC kinase, CK2, EGFR tyrosine kinase, p56lck, p56lyn, p60c-src, v-abl and insulin receptor tyrosine kinase are not inhibited or are weakly inhibited at 1mM. It delays mouse oocyte maturation and inhibits the growth of a variety of human cell lines including Rhabdomyosarcoma cell line Rh1, Rh18, Rh28 and Rh30; MCF-7, KB-3-1 and their adriamycin-resistant counterparts (IC50=18-86µM). It inhibits DNA synthesis in interleukin-2-stimulated T lymphocytes and triggers a G1 arrest similar to interleukin-2 deprivation. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons. N9-Isopropyl-olomoucine and the negative control Iso-olomoucine are also available.

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PKCdelta inhibitor

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Natural source of phorbol and phorbol esters.

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BCRP inhibitor

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Activates PPAR alpha and the phospholipase C (PLC) signalling pathway. Stimulates peroxisomal fatty acyl-CoA oxidase activity. These effects can be blocked by staurosporine (Prod. No. ALX-380-014). Exhibits significant cytotoxic activities against numerous tumor cell lines. Binds tubulin. Inhibits angiogenesis. Reduces HIF-1alpha protein levels. Induces apoptosis. Antifungal.

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Insulin sensitising agent.

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Produced in E. coli.

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Produced in E. coli.

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Blocks actin filament assembly

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Produced in E. coli.

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Produced in E. coli.

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BCRP inhibitor

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Semisynthetic (from GM1).

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Prevents neurotoxicity of glutamate on neuronal cells.

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D-myo-Inositol-1-monophosphate dipotassium salt ≥98% (by HPLC)

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Activator of CB1 receptor and TRPV1

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PARP5a inhibitor

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Inhibits the recruitment of the co-activators β-catenin and GRIP1

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Produced in HEK 293 cells. The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1.

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Produced in HEK 293 cells. The cysteine-rich region of human DR3 (aa 25-199) is fused to the Fc portion of human IgG1.

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Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75NTR) (aa 1-250) is fused to the Fc portion of human IgG1.

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Fas ligand

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Produced in E. coli. Human IL-1β (interleukin-1β) (aa 117-270) is fused to a linker peptide (10 aa) and an N-terminal FLAG®-tag.

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Broad-spectrum kinase inhibitor

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PARP inhibitor

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A colorimetric immunometric ELISA kit for the rapid measurement of NGAL in dog samples. Absorbance is read at 450 nm.