Specifications
- Antigen name:IFN-gamma
- Clonality:Monoclonal
- Clone:1-D1K
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Host:Mouse
- Isotype:IgG1
- Reactivity:Non-human primates,Human
- Gene ID:3458
- Pk:100 Tests
Specifications
About this item
Mouse monoclonal antibody against human IFN-gamma, FITC-conjugated.
- Nk cells
- T cells
This mouse monoclonal antibody (clone 1-D1K) reacts with human interferon-gamma (IFN-γ). IFN-γ is an ~17 kDa protein produced in response to mitogenic and antigenic stimuli by T and NK cells, and in smaller amounts by dendritic cells and macrophages. IFN-γ is controlled by cytokines such as IL-12 and IL-18 secreted in response to infection (Schroder et al.). IFN-γ functions as a homodimer that is composed of interconnecting alpha-helices (Thiel et al.), which bind to the alpha subunit of the IFN-γ receptor (IFNGR) on target cells, resulting in receptor crosslinking and activation of JAK-STAT signaling (Kak et al.). IFN-γ mediates many cellular effects, including upregulation of class I and II antigen presentation pathways, antiviral and antimicrobial mechanisms, antiproliferative and apoptotic effects, immunomodulation, and leukocyte trafficking (Schroder et al.).
Type: Anti-IFN-gamma Mouse Monoclonal Antibody [clone: 1-D1K] (FITC)
Antigen: IFN-gamma
Clonality: Monoclonal
Clone: 1-D1K
Conjugation: FITC
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Non-Human Primate