70093 Results for: "Vertical+Gel+Electrophoresis+Systems&amp"

Supplier: NERL DIAGNOSTICS CORP MS

SERUM-FREE MEDIUM KIT

Supplier: Analytik Jena US

The Biometra Thermal Cycler product family offers PCR devices ranging from standard to premium equipment – all designed in line with the common principles of being reliable, easy to use, and precise.

Supplier: Expression Systems

SF9 CELLS SUSPENSION CULTURE

Supplier: WORLD PRECISION INSTRUMENTS LLC

EVOM™ Manual replaces EVOM3, EVOM2 and ERS-2.

Supplier: Expression Systems

DNA BACULOVIRUS LINEARIZED BESTBAC 2.0

Supplier: Expression Systems

LINEARIZED VIRUS BACULOVIRUS DNA 2-8 DEG

Supplier: Expression Systems

MEDIUM INSECT CELL CULT PROTEIN-FREE 1L

Supplier: Expression Systems

MEDIUM ESF SFM MAMMALIAN CELL CULTURE 1L

Supplier: Biosensis

The amyloid beta peptide is derived from the cleavage of the Amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. However, the form(s) of amyloid-beta peptide (Aβ) associated with the pathology characteristic of Alzheimer’s disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Aβ accumulation is an area of considerable research and controversy principally because antibodies thought to be specific for Aβ have been shown to actually detect intraneuronal APP and not Aβ exclusively.
MOAB-2 (mouse IgG2b) is a pan-specific, high-titer antibody to Aβ residues 1-4 as demonstrated by biochemical and immunohistochemical analyses (IHC), and is highly specific just to amyloid beta peptide. MOAB-2 did not detect APP or APP-CTFs in cell culture media/lysates (HEK-APPSwe or HEK APPSwe/BACE1) or in brain homogenates from transgenic mice expressing 5 familial AD (FAD) mutation (5xFAD mice).
Using IHC on 5xFAD brain tissue, MOAB-2 immunoreactivity co-localized with C-terminal antibodies specific for Aβ40 and Aβ42. MOAB-2 did not co-localize with either N- or C-terminal antibodies to APP. In addition, no MOAB-2-immunreactivity was observed in the brains of 5xFAD/BACE-/- mice, although significant amounts of APP were detected by N- and C-terminal antibodies to APP, as well as by 6E10. In both 5xFAD and 3xTg mouse brain tissue, MOAB-2 co-localized with cathepsin-D, a marker for acidic organelles, further evidence for intraneuronal Aβ, distinct from Aβ associated with the cell membrane. MOAB-2 demonstrated strong intraneuronal and extra-cellular immunoreactivity in 5xFAD and 3xTg mouse brain tissues. Detects human, rat, other species not yet tested. By Dot Blot, MOAB-2 detected rat Aβ40 and human Aβ40, albeit with less affinity than for Aβ42 (Youmans KL et al., 2012).

Supplier: Janitorial Supplies

Fast-drying fluid with excellent coverage.

Supplier: G-Biosciences

Immobilized Octylphenolpoly(ethyleneglycolether)x is use for refolding of recombinant proteins that were expressed in aggregated form or as inclusion bodies in genetically engineered cells such as E. coli.

Supplier: StatLab

With an internal cavity a third of the depth of the conventional Supa Mega, the PathFlow Supa Mega Mothership Cassette provides an innovative solution for the processing, embedding, and tracking of large tissue specimens.

Supplier: StatLab

With an internal cavity a third of the depth of the conventional Supa Mega, the PathFlow Supa Mega Mothership Cassette provides an innovative solution for the processing, embedding, and tracking of large tissue specimens.