132134 Results for: "Shakers+and+Mixers&pageNo=10&view=list"

Supplier: BioVendor

Tissue-type plasminogen activator (t-PA) is a serine protease which occurs in blood plasma, serum, other body fluids, tissues and conditioned media of certain cultured cells.

Supplier: Electron Microscopy Sciences

The EasyDip™ Slide Staining System has two components: a square staining jar and a 12-position vertical slide staining rack. Jars can be loosely joined to each other laterally using the stainless steel holder making sure they are kept in the same order when moved around on the lab counter. The jars are available in five different colors to help better identity contents or applications.

Supplier: Jackson Immunoresearch Lab

Whole IgG antibodies are isolated as intact molecules from antisera by immunoaffinity chromatography. They have an Fc portion and two antigen binding Fab portions joined together by disulfide bonds and therefore they are divalent. The average molecular weight is reported to be about 160 kDa. The whole IgG form of antibodies is suitable for the majority of immunodetection procedures and is the most cost effective. Based on immunoelectrophoresis and/or ELISA, the antibody reacts with the heavy chain of rat IgM but not with rat IgG or the light chains of rat immunoglobulins. No antibody was detected against non-immunoglobulin serum proteins. The antibody has been tested by ELISA and/or solid-phase adsorbed to ensure minimal cross-reaction with human, bovine and horse serum proteins, but it may cross-react with IgM from other species.

Supplier: Prosci

IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Supplier: Prosci

Stem cell factor (SCF), also known as cKit ligand (KL), mast cell growth factor (MGF) and steel factor (SLF), is a widely expressed 28-40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/cKit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.

Supplier: Peprotech

CT-1 is a member of the IL-6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL-11, IL-6 and possibly NNT-1/BSF¬-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung, and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Biologically active human CT-1 is synthesized as a 201 amino acid polypeptide lacking a hydrophobic N-terminal secretion signal sequence. Recombinant Human Cardiotrophin-1 is a 21.1 kDa protein consisting of 200 amino acid residues.

Supplier: Peprotech

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant Human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

Supplier: Prosci

DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein, is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®.

Supplier: Promega Corporation

Recombinant human HER4 (amino acids 682-993) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. HER4 or ERBB4 is a transmembrane receptor tyrosine kinase that belongs to the epidermal growth factor receptor family.

Supplier: Promega Corporation

Recombinant human FGFR4 (460-end) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag. FGFR4 is a member of the fibroblast growth factor receptor family, which play a role in mitogenesis and differentiation.

Supplier: Promega Corporation

TAOK1 is a serine/threonine-protein kinase involved in regulation of the p38-containing stress-responsive MAP kinase pathway and extracellular signal-regulated protein kinase (ERK) kinases (MEKs).

Supplier: Promega Corporation

Recombinant human HER2 (amino acids 676-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. HER2 gene encodes a cell-surface glycoprotein tyrosine kinase receptor with extensive homology to epidermal growth factor receptor.

Supplier: Genscript

GenScript MonoRab™ anti-His tag (C-term) antibody (25B6E11), mAb, rabbit specifically recognizes His tags placed at C-terminal and internal regions of His-fusion
proteins. This product is not recommended for N-terminal His-fusion protein detection and nbsp.

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 650 conjugates provide vibrant far-red fluorescence with comparable or improved performance compared to other dyes for fluorescent applications. DyLight® 650 dye conjugates have tight excitation/emission spectra that are ideal for multi-color applications. DyLight® 650 conjugated secondary antibodies are available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 652nm / 672nm Emission Color = Far Red (Similar Dyes: Alexa Fluor 647, Cy5)

Supplier: Proteintech

Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 550 conjugates provide vibrant orange-to-red fluorescence with better performance than other rhodamine derivatives, including Alexa Fluor 555, TRITC and Cy3 for fluorescent applications. DyLight® 550 conjugates have tight excitation/emission spectra that are ideal for multicolor applications. DyLight® 550 conjugated secondary antibodies are used in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 562nm / 576nm Emission Color = Orange to Red (Similar Dyes: Alexa Fluor 555, Cy3, TRITC)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 550 conjugates provide vibrant orange-to-red fluorescence with better performance than other rhodamine derivatives, including Alexa Fluor 555, TRITC and Cy3 for fluorescent applications. DyLight® 550 conjugates have tight excitation/emission spectra that are ideal for multicolor applications. DyLight® 550 conjugated secondary antibodies are used in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 562nm / 576nm Emission Color = Orange to Red (Similar Dyes: Alexa Fluor 555, Cy3, TRITC)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 550 conjugates provide vibrant orange-to-red fluorescence with better performance than other rhodamine derivatives, including Alexa Fluor 555, TRITC and Cy3 for fluorescent applications. DyLight® 550 conjugates have tight excitation/emission spectra that are ideal for multicolor applications. DyLight® 550 conjugated secondary antibodies are used in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 562nm / 576nm Emission Color = Orange to Red (Similar Dyes: Alexa Fluor 555, Cy3, TRITC)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 633 conjugates fluoresces red with physical properties comparable to other 633 dyes. DyLight® 633 is ideal for multi-color applications. DyLight® 633 is available as reactive labeling agents and as conjugates of secondary antibodies and biotin-binding proteins for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 638nm / 658nm Emission Color = Red (Similar Dyes: Alexa Fluor 633)

Supplier: YSI

The YSI MultiLab line includes the 4010-1 (single channel), 4010-2 (dual channel) and 4010-3 (three channel) instruments providing easy to use and calibrate menu-driven operation ideal for the laboratory

Supplier: Prosci

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1, NOD1, and NOD2. These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.

Supplier: Prosci

HTR3A belongs to the ligand-gated ion channel receptor superfamily. It is the subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.

Supplier: Bulldog Bio

CellCover maintains a cell’s native state offering instant 'freezing' of proteins, RNA, and DNA in their cellular context. It is ideal for preserving morphology, mRNA expression patterns and protein epitopes for furhter analysis, among other uses.

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 488 conjugates provide exceptional performance for a wide array of fluorescence-base applications at a lower cost than other 488-range dyes. DyLight® 488 shows greater photostability than traditional fluorescein-based dyes and has a greater range of pH insensitivity (pH 4-9). DyLight® 488 conjugates are available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 493nm / 518nm Emission Color = Green (Similar Dyes: Alexa Fluor 488, Cy2, FITC)

Supplier: Proteintech

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction . BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria . The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis .

Supplier: Proteintech

SESN is a family of highly conserved, stress-inducible genes that can defend the cell against oxidative damage and oncogenic signaling. SESN2 ,which belongs to the SESN family, has been implicated as a tumor suppressor that can inhibit angiogenesis and promote autophagy, underscoring the importance of elucidating the molecular mechanism by which SESN2 regulates pathways of metabolism and survival.. Sesn2 encodes a 480 amino acid protein which can run as a 60 kDa band on SDS-polyacrylamide gel electrophoresis.

Supplier: Prosci

Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons. We raised this polyclonal antibody against a peptide representing the sequence around Ser19 in rat TH purified. This antibody is suitable for most immunochemical applications in a variety of mammalian and some non-mammalian species.

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 550 conjugates provide vibrant orange-to-red fluorescence with better performance than other rhodamine derivatives, including Alexa Fluor 555, TRITC and Cy3 for fluorescent applications. DyLight® 550 conjugates have tight excitation/emission spectra that are ideal for multicolor applications. DyLight® 550 conjugated secondary antibodies are used in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 562nm / 576nm Emission Color = Orange to Red (Similar Dyes: Alexa Fluor 555, Cy3, TRITC)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 594 conjugates generate red fluorescence and shows wide excitation wavelength separation from green fluorophores for multi-color applications with reduced bleedthrough. The physical characteristics of DyLight® 594 are comparable to other 594 dyes. DyLight® 594 is available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 593nm / 618nm Emission Color = Red (Similar Dyes: Alexa Fluor 594, Texas Red)

Supplier: Prosci

RAMP3 is a member of the RAMP family of single-transmembrane-domain proteins, called receptor-activity-modifying proteins. RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. Co-expression of RAMP3 with CRLR results in the production of a functional adrenomedullin receptor.