6884 Results for: "Selleck Chemicals"

Supplier: Selleck Chemicals

Escitalopram oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.

Supplier: Selleck Chemicals

GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM

Supplier: Selleck Chemicals

Imiquimod is a novel synthetic agent with immune response modifying activity.

Supplier: Selleck Chemicals

Tofacitinib citrate (CP-690550 citrate) is a novel inhibitor of JAK with IC50 of 1 nM, 20 nM and 112 nM against JAK3, JAK2, and JAK1, respectively.

Supplier: Selleck Chemicals

Plerixafor (AMD3100) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively.

Supplier: Selleck Chemicals

Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

Supplier: Selleck Chemicals

Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with K_i of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

Supplier: Selleck Chemicals

Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μm in a cell-free assay, promotes hESC survival after single-cell dissociation.

Supplier: Selleck Chemicals

Tacrolimus is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin creating a new complex.

Supplier: Selleck Chemicals

Alisertib (MLN8237) is a selective aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay

Supplier: Selleck Chemicals

Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.

Supplier: Selleck Chemicals

β-Sitosterol is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol.

Supplier: Selleck Chemicals

HPI-4 (Ciliobrevin A) is a hedgehog (Hh) pathway antagonist. It blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo.

Supplier: Selleck Chemicals

Ciclesonide is a glucocorticoid used to treat obstructive airway diseases.

Supplier: Selleck Chemicals

A small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM

Supplier: Selleck Chemicals

Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43, 0.75 and 0.18 μM, respectively

Supplier: Selleck Chemicals

Posaconazole is an inhibitor primarily of CYP3A4, but it does not inhibit the activity of other CYP enzymes; Also an inhibitor of sterol C14ɑ demethylase inhibitor with IC50 of 0.25 μM.

Supplier: Selleck Chemicals

PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with an IC50 of 0.33 nM, roughly 500-fold more potent than CI-1040 on the phosphorylation of ERK1 and ERK2.

Supplier: Selleck Chemicals

Raltegravir is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000 fold selectivity for HIV-1 IN over several related Mg²⁺ dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human α-, β-, γ-polymerases.

Supplier: Selleck Chemicals

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.

Supplier: Selleck Chemicals

MG-132 is a potent cell-permeable inhibitor of proteasome and calpain with an IC₅₀ of 100 nM.

Supplier: Selleck Chemicals

MLN9708 gets hydrolyzed to its biologically active form MLN2238, on exposure to aqueous solutions or plasma

Supplier: Selleck Chemicals

Busulfan, Purity: 99.90 %, Cas number: 55-98-1, Molecular Weight: 246.3, Form: powder, cell cycle non-specific alkylating antineoplastic agent, DMSO Solubility: 49 mg/mL (198.94 mM), Storage: -20 deg C, Size: 50MG

Supplier: Selleck Chemicals

CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.

Supplier: Selleck Chemicals

Tadalafil is a PDE-5 inhibitor with IC₅₀ of 1.8 nM.

Supplier: Selleck Chemicals

Trametinib is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.

Supplier: Selleck Chemicals

Pimaricin ( synonym Natamycin), a natural and versatile anti-fungal agent during fermentation by the bacterium Streptomyces natalensis, commonly found in soil, with little to no flavour interference.

Supplier: Selleck Chemicals

Linezolid (Zyvox) is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics

Supplier: Selleck Chemicals

YM201636 INHIBITOR 99 % 371942-69-7 25MG

Supplier: Selleck Chemicals

FLAVOPIRIDOL (ALVOCIDIB) 99.25 % 5MG