1910 Results for: "PF-04979064&amp"

Supplier: Adipogen

PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with an IC(50) of 9.1nM for the PI3K family when tested AKT phosphorylation in BT20 cells. In direct kinase assays, PF-04979064 has potent Ki values against PI3Kalpha (Ki= 0.13nM human, 0.299nM mouse) and PI3Kgamma (Ki=0.111nM), and PI3Kdelta (Ki=0.122nM). In contrast, Ki values for non-PI3K kinases such as mTOR were 10X higher at 1.42 nM.

Supplier: Ambeed

PF-04418948 98+%

Supplier: Aladdin Scientific

AMP PNP ≥90% (by HPLC)

Supplier: Abcam

PF-3758309

Supplier: Ambeed

PF-9366 98%

Supplier: VWR

5% water has been added to maintain liquidity at room temperature.

Supplier: Adipogen

Antagonizing the Chk1-mediated cell cycle checkpoints has emerged as an attractive target for anticancer therapy. If Chk1 activity is blocked, DNA-damaged or spindle-disrupted cells would exit cell cycle arrest before full repair and subsequently undergo mitotic catastrophe or cell death. Chk1 inhibitors consequently increase the therapeutic index of DNA-damaging or antimitotic agents as well. PF-0477736 is a selective, potent ATP-competitive Chk1 inhibitor, derived from PF-0394691, inhibits Chk1 (Ki, 0.49nM) and Chk2 (Ki, 47nM) in vitro. In tests, PF-0477736 was identified as a potent, selective ATP-competitive small-molecule inhibitor that inhibits Chk1 with a Ki of 0.49nM. PF-0477736 abrogates cell cycle arrest induced by DNA damage and enhances cytotoxicity of clinically important chemotherapeutic agents, including gemcitabine and carboplatin. In xenografts, PF-0477736 enhanced the antitumor activity of gemcitabine in a dose-dependent manner. PF-0477736 combinations were well tolerated with no exacerbation of side effects commonly associated with cytotoxic agents.

Supplier: Adipogen

Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.

Supplier: Ambeed

Pf-06282999 98+%

Supplier: Ambeed

PF-562271 98+%

Supplier: Adipogen

PF04217903 is a novel orally bio-available, small molecule tyrosine kinase inhibitor with potential anti-neoplastic activity. It is an extremely selective MET inhibitor, with an IC(50) of 4.8nM.

Supplier: Adipogen

PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nM, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nM. PF-562,271 was evaluated against multiple kinases and displays 100x selectivity against a long list of nontarget kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/mL using injections.

Supplier: Abcam

PF-9366

Supplier: Ambeed

PF-562271 besylate 98%

Supplier: Ambeed

PF-04708671 98%

Supplier: Ambeed

PF-06463922 98%

Supplier: ABCAM INC CA

Potent and selective FAK inhibitor (IC₅₀ =4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397phosphorylation in cultured cells (IC₅₀ =30 to 100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.

Supplier: Enzo Life Sciences

FAAH inhibitor

Supplier: ABCAM INC CA

Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC₅₀ values are 7.7 and 14 nM for CK1ε and CK1δ, respectively). Shows >300-fold selectivity over CK2 and selectivity over more than 40 other kinases. Alters circadian rhythms in vivo. Also available in simple stock solutions - add 1 ml of water to get an exact, ready-to-use concentration.

Supplier: Ambeed

PF-06840003 98%

Supplier: Ambeed

PF-05212384 ≥98%

Supplier: Thermo Scientific Chemicals

AMP (2-Amino-2-methylpropanol), (max. 5% H₂O) 95%

Supplier: Enzo Life Sciences

Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function.

Supplier: ABCAM INC CA

Antibiotic PF 1052

Supplier: AAT Bioquest

AMP-Fluorescein conjugate calibrator is desigend to use with AAT Bioquests' green fluorescent FAM-cAMP PDE IV substrate, a cAMP derivative that is a specific substrate for phosphodiesterase (PDE) IV.

Supplier: Cayman Chemical Company

Cyclic di-AMP (sodium salt), Purity: >/=98%, A second messenger produced by bacteria, but not by mammals, Synonyms: c-di-AMP, Cyclic di-Adenosine monophosphate, 3',5'-Cyclic diadenylic acid, Cyclic diadenylate, Size: 500ug

Supplier: Ambeed

PF-04965842 ≥98%

Supplier: Adipogen

Antibiotic PF 1052 is antifungal and phytotoxic.

Supplier: Ambeed

PF 543 HCl ≥97%

Supplier: Ambeed

1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea, Purity: 98+%, CAS Number: 1095173-27-5, Appearance: Solid, Storage: Sealed in dry, 2-8 C, Size: 1mg