"Other Essentials"

Supplier: Chem-Impex International

Malonic acid anhydrous is a versatile dicarboxylic acid known for its significant role in organic synthesis and various industrial applications. This compound is characterized by its ability to act as a building block in the synthesis of pharmaceuticals, agrochemicals, and polymers. Its unique structure allows it to participate in a range of chemical reactions, including esterification and condensation, making it an essential reagent in laboratories and manufacturing processes. Researchers and industry professionals utilize malonic acid anhydrous for the synthesis of barbiturates and other bioactive compounds, highlighting its importance in medicinal chemistry.

Supplier: Peprotech

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.  IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response.  IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.  Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond. Manufactured using all Animal-Free reagents.

Supplier: Peprotech

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.  IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response.  IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.  Recombinant Rat IL-2 is a 15.3 kDa protein containing 134 amino acid residues. Manufactured using all Animal-Free reagents.

Supplier: Goodfellow

Goodfellow's Cobalt/Chromium/Iron/Nickel/Molybdenum/Manganese Alloy Spooled Wire (Co40/Cr20/Fe15/Ni15/Mo 7/Mn 2/C/Be) is available in 42 variations. This alloy wire offers high strength and corrosion resistance, making it ideal for springs, fasteners and other demanding applications where fatigue strength and biocompatibility are essential. As part of Goodfellow's extensive inventory, this alloy wire provides researchers and engineers with the flexibility to select the optimal composition and properties for their specific needs across a wide range of scientific, industrial, and medical applications.

Supplier: Chem-Impex International

Boc-(2S,4S)-4-phenylpyrrolidine-2-carboxylic acid is a versatile compound widely utilized in the field of organic synthesis and medicinal chemistry. This compound serves as a crucial building block in the development of various pharmaceuticals, particularly in the synthesis of peptide-based drugs and other bioactive molecules. Its unique structure, featuring a Boc (tert-butyloxycarbonyl) protecting group, allows for selective reactions, making it an essential tool for chemists aiming to create complex molecular architectures.

Supplier: Chem-Impex International

Ammonium thiocyanate is a versatile chemical compound widely utilized in various industrial and research applications. Known for its solubility in water and ability to form complexes, it serves as a crucial reagent in analytical chemistry, particularly in the determination of metal ions. Its unique properties make it an essential component in the production of fertilizers, where it acts as a nitrogen source, enhancing plant growth and yield. Additionally, ammonium thiocyanate is employed in the synthesis of other thiocyanate compounds, which are valuable in pharmaceuticals and agrochemicals.

Supplier: Chem-Impex International

Boc-sarcosine is a versatile amino acid derivative that plays a crucial role in peptide synthesis and pharmaceutical research. This compound, also known as N-Boc-sarcosine, is characterized by its protective Boc (tert-butyloxycarbonyl) group, which enhances its stability and reactivity in various chemical reactions. Researchers utilize Boc-sarcosine for the efficient synthesis of peptides and other bioactive molecules, making it an essential building block in drug development and biochemistry. Its unique structure allows for selective reactions, facilitating the creation of complex compounds with high specificity.

Supplier: Prosci

HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.

Supplier: Chem-Impex International

5-Fluorocytosine is a fluorinated pyrimidine analog of cytosine, primarily recognized for its potent antifungal properties. This compound is widely utilized in the treatment of systemic fungal infections, particularly in immunocompromised patients. Its mechanism of action involves the inhibition of fungal DNA and RNA synthesis, making it an essential agent in combination therapies for conditions such as cryptococcal meningitis and candidiasis. Researchers appreciate 5-Fluorocytosine for its ability to enhance the efficacy of other antifungal agents, providing a synergistic effect that can lead to improved patient outcomes.

Supplier: Chem-Impex International

2-Bromoacetamide is a versatile chemical compound recognized for its significant role in various research and industrial applications. This compound, with its unique bromine substituent, serves as a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. Its reactivity allows it to participate in nucleophilic substitution reactions, making it an essential building block for creating more complex molecules. Researchers often utilize 2-Bromoacetamide in the synthesis of amides and other nitrogen-containing compounds, which are crucial in drug discovery and development processes.

Supplier: Biotium

Podocalyxin is a member of the CD34 transmembrane sialomucin family. It is over-expressed on the podocyte foot projections and plays essential roles in kidney development and homeostasis, blood filtration and urine formation. It is also expressed on vascular endothelia, hematopoietic progenitors and a subset of neurons. Overexpression of podocalyxin may be linked to more aggressive tumor behavior. Podocalyxin antibody can identify podocytes in the urine (podocyturia) that may indicate glomerular disease, pre-eclampsia, and other kidney pathology.

Supplier: Chem-Impex International

Fmoc-S-trityl-L-homocysteine is a valuable compound widely utilized in peptide synthesis and biochemistry. This derivative of homocysteine features a fluorenylmethoxycarbonyl (Fmoc) protecting group and a trityl (Tr) group, making it an essential building block for the synthesis of peptides and proteins. Its unique structure allows for selective protection of the amino group, facilitating the development of complex peptide sequences. Researchers appreciate its stability under various reaction conditions, which enhances its utility in solid-phase peptide synthesis (SPPS) and other synthetic methodologies.

Supplier: Chem-Impex International

L-Asparagine anhydrous is a vital amino acid that plays a crucial role in various biological processes. Known for its ability to support protein synthesis and cellular metabolism, this compound is particularly valuable in the fields of biochemistry and nutrition. L-Asparagine is commonly utilized in cell culture media, enhancing the growth and viability of cells, which is essential for research in biotechnology and pharmaceuticals. Additionally, it serves as a precursor for the synthesis of other amino acids and neurotransmitters, making it significant in neurological studies and therapeutic applications.

Supplier: Bioss

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.

Supplier: Chem-Impex International

Vitamin B12, also known as cobalamin, is a vital water-soluble vitamin that plays a crucial role in various biological processes, including DNA synthesis, red blood cell formation, and neurological function. This compound is particularly significant in the fields of nutrition and medicine, where it is widely used as a dietary supplement to prevent and treat vitamin B12 deficiency, which can lead to anemia and neurological disorders. Its unique cobalt-containing structure distinguishes it from other vitamins, making it essential for metabolic processes and energy production in the body.

Supplier: Prosci

LHX8 is a member of the LIM homeobox family. Members of this family share common structural features. They all contain 2 tandemly repeated cysteine-rich double-zinc finger motifs, called LIM domains, in addition to a homeodomain. The homeodomain is a DNA-binding domain, and the LIM domains are essential for regulating the activity of these molecules by interacting with other proteins. Members of the family are required for the patterning or the specification and differentiation of different cell types during embryonic development.