"Other Essentials"

Supplier: Bioss

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity).

Supplier: Prosci

MCM8 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Supplier: Proteintech

ADP-ribosylation factors (ARFs) are members of the ARF family of GTP-binding proteins of the Ras superfamily, with 20kda protein size. ARFs bind and regulate GTP/GDP cycle by alternating between the active GTP-bound and inactive GDP-bound conformations. ARF family proteins are essential and ubiquitous in eukaryotes. Six highly conserved members of the family have been identified in mammalian cells. They function in vesicular traffic and actin remodelling and other bioprocesses in cells. ARF3 is 95% homolouous to ARF1. Its function was not fully understood. .The antibody is specific to ARF3. If has no cross reaction to other ARF members.

Supplier: Bioss

Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 3 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).

Supplier: Bioss

Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 3 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).

Supplier: Chem-Impex International

Protamine sulfate salt from salmon is a highly effective anticoagulant used primarily in clinical settings to reverse the effects of heparin during surgical procedures or in patients experiencing heparin overdose. This compound is a mixture of proteins derived from salmon sperm, known for its ability to bind to heparin, thereby neutralizing its anticoagulant properties. Its rapid action and safety profile make it an essential agent in cardiopulmonary bypass surgeries and other medical interventions where heparin is utilized.

Supplier: Chem-Impex International

D-Alanine is a naturally occurring amino acid that plays a crucial role in various biological processes. As a building block of proteins, it is essential for the synthesis of peptides and proteins in living organisms. D-Alanine is particularly significant in the field of biochemistry and pharmaceuticals, where it is utilized in the development of antibiotics and other therapeutic agents. Its unique stereochemistry allows it to interact specifically with certain enzymes and receptors, making it a valuable compound in drug design and development.

Supplier: Chem-Impex International

Na-Z-L-asparagine is a vital amino acid derivative that plays a significant role in various biochemical processes. This compound is recognized for its utility in the synthesis of peptides and proteins, making it an essential ingredient in the pharmaceutical and biotechnology industries. Its unique structure allows it to serve as a building block for more complex molecules, facilitating research in drug development and therapeutic applications. Researchers often utilize Na-Z-L-asparagine in the formulation of enzyme inhibitors and other bioactive compounds, enhancing the efficacy of their studies.

Supplier: Chem-Impex International

5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-guanosine is a versatile nucleoside derivative that plays a crucial role in the synthesis of oligonucleotides and other nucleic acid-based products. This compound is particularly valued in molecular biology and biochemistry for its protective groups, which enhance the stability and efficiency of nucleic acid synthesis. Its unique structure allows for selective reactions, making it an essential building block in the development of therapeutic agents, diagnostic tools, and research applications.

Supplier: Rockland Immunochemical

CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.

Supplier: Bioss

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.

Supplier: Bioss

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.

Supplier: Bioss

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity).

Supplier: Bioss

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.

Supplier: Bioss

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses (By similarity).

Supplier: Peprotech

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.  IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response.  IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.  Recombinant Rat IL-2 is a 15.3 kDa protein containing 134 amino acid residues. Manufactured using all Animal-Free reagents.