74322 Results for: "Open+Circulator+Systems&amp"

Supplier: Genetex

Nucleolin, which is identical to human DNA helicase IV, is a major nucleolar phosphoprotein which is associated with preribosomal RNA and is implicated in the early stage of preribosomal RNP assembly and processing. This 100 kDa protein has three major domains: a N-terminal domain comprised of long acidic stretches interspersed with basic repeats, similar to the structure of a high mobility group-type protein (this domain is responsible for the ablility of nucleolin to modulate chromatin condensation), a central domain that contains four RNA binding elements, a C-terminal domain approximately 85 amino acids long that is rich in glycine, arginine, and phenylalanine residues. Nucleolin fluctuates in parallel to DNA synthesis; intact 100 kDa protein is the major species in actively dividing cells, whereas the degraded forms are relativley abundant in nondividing cells. Nucleolin can unwind RNA-RNA duplexes, as well as DNA-DNA and DNA-RNA duplexes. Nucleolin also interacts directly with DNA topoisomerase I. It is located mainly in dense fibrillar regions of the nucleolus. Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and preribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. It interacts with APTX and contains 4 RNA recognition motif (RRM) domains.

Supplier: Thermo Fisher Scientific

Get premium performance and ultimate flexibility with the Orion™ Versa Star Pro™ pH Benchtop Meter for pH, mV, ORP, and temperature on customizable color display.

Supplier: Enochs Manufacturing

The ENCORE 4500 series of low-access high-low power tables includes the 4550, 4520 and 4510 offers a low access height of 18.5" to meet ADA recommendations and a 700 lbs. patient weight capacity to allow medical facilities to better accommodate patients of size and offer barrier free access to table for examinations and procedures.

Supplier: WORLD PRECISION INSTRUMENTS LLC

EVOM™ Manual replaces EVOM3, EVOM2 and ERS-2.

Supplier: Rockland Immunochemical

Mouse IgG TrueBlot® is a unique DyLight™ 800 conjugated anti-mouse IgG immunoblotting (second step) reagent. Mouse IgG TrueBlot® enables detection of immunoblotted target protein bands, without hindrance by interfering immunoprecipitating immunoglobulin heavy and light chains. It is easy to generate publication-quality IP/Fluorescent Western Blot data with Mouse IgG TrueBlot®, simply substitute the conventional DL800 anti-mouse IgG blotting reagent with Fluorescent Mouse TrueBlot® Antibody DyLight™ 800 and follow the prescribed protocol for sample preparation and immunoblotting.

Mouse IgG TrueBlot® is ideal for use in protocols involving immunoblotting of immunoprecipitated proteins. TrueBlot preferentially detects the non-reduced form of mouse IgG over the reduced, SDS-denatured form of IgG. When the immunoprecipitate is fully reduced immediately prior to SDS-gel electrophoresis, reactivity of Mouse IgG TrueBlot® with the 55 kDa heavy chains and the 23 kDa light chains of the immunoprecipitating antibody is minimized thereby eliminating interference by the heavy and light chains of the immunoprecipitating antibody in IP/Western blotting applications. Applications include studies examining post-translational modification (e.g., phosphorylation or acetylation) or protein-protein interactions. Fluorescent Mouse TrueBlot® Antibody DyLight™ 800 may also be used for detection in immunoassays that do not employ immunoprecipitation.

Supplier: AVANTOR PERFORMANCE MATERIALS US

L-(+)-Glutamic Acid, Monosodium Salt, Monohydrate, F.C.C.

Supplier: Biosensis

The amyloid beta peptide is derived from the cleavage of the Amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. However, the form(s) of amyloid-beta peptide (Aβ) associated with the pathology characteristic of Alzheimer’s disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Aβ accumulation is an area of considerable research and controversy principally because antibodies thought to be specific for Aβ have been shown to actually detect intraneuronal APP and not Aβ exclusively.
MOAB-2 (mouse IgG2b) is a pan-specific, high-titer antibody to Aβ residues 1-4 as demonstrated by biochemical and immunohistochemical analyses (IHC), and is highly specific just to amyloid beta peptide. MOAB-2 did not detect APP or APP-CTFs in cell culture media/lysates (HEK-APPSwe or HEK APPSwe/BACE1) or in brain homogenates from transgenic mice expressing 5 familial AD (FAD) mutation (5xFAD mice).
Using IHC on 5xFAD brain tissue, MOAB-2 immunoreactivity co-localized with C-terminal antibodies specific for Aβ40 and Aβ42. MOAB-2 did not co-localize with either N- or C-terminal antibodies to APP. In addition, no MOAB-2-immunreactivity was observed in the brains of 5xFAD/BACE-/- mice, although significant amounts of APP were detected by N- and C-terminal antibodies to APP, as well as by 6E10. In both 5xFAD and 3xTg mouse brain tissue, MOAB-2 co-localized with cathepsin-D, a marker for acidic organelles, further evidence for intraneuronal Aβ, distinct from Aβ associated with the cell membrane. MOAB-2 demonstrated strong intraneuronal and extra-cellular immunoreactivity in 5xFAD and 3xTg mouse brain tissues. Detects human, rat, other species not yet tested. By Dot Blot, MOAB-2 detected rat Aβ40 and human Aβ40, albeit with less affinity than for Aβ42 (Youmans KL et al., 2012).

Supplier: GLOBEPHARMA

Unit-dose and bulk powder, liquid, and semi-solid samplers available in various lengths and configurations.

Supplier: GLOBEPHARMA

Unit-dose and bulk powder, liquid, and semi-solid samplers available in various lengths and configurations.

Supplier: Binder

Options for Binder KB, KBP PRO, KBF and KBF PRO

Supplier: StatLab

With an internal cavity a third of the depth of the conventional Supa Mega, the PathFlow Supa Mega Mothership Cassette provides an innovative solution for the processing, embedding, and tracking of large tissue specimens.

Supplier: StatLab

With an internal cavity a third of the depth of the conventional Supa Mega, the PathFlow Supa Mega Mothership Cassette provides an innovative solution for the processing, embedding, and tracking of large tissue specimens.