59784 Results for: "O-Benzylhydroxylamine+hydrochloride&pageNo=-1"

ARS-853 (ARS853) ARS-853 is a selective, covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation. ARS-853 also induces apoptosis .Targets K-Ras(G12C) (in H358 cells) 2.5 μM In vitro ARS-853 treatment of KRASG12C cells led to a dose-dependent and nearly complete inhibition of CRAF-RBD (RBD)-mediated pulldown of KRAS from lysates, with an IC50 of approximately 1 μmol/L. Treatment of H358 cells by ARS-853 resulted in a significant loss of KRAS–CRAF interactions. Consistent with an inactive state of KRASG12C once bound to ARS-853, downstream signaling through both MAPK (including pMEK, pERK, and pRSK) and PI3K signaling (pAKT) pathways was inhibited by ARS-853 in H358 and other KRASG12C cell lines. The inhibition of RAF-RBD pulldown and KRAS downstream signaling was sustained over a period of 72 hours, accompanied by G1 cell-cycle arrest, loss of Cyclin D1 and Rb expression, and an increase in the cell-cycle inhibitor p27 KIP1.

Expand 1 Items

4-Chlorodiphenyl sulfone

Supplier: Aladdin Scientific

4-Chlorophenyl phenyl sulfone was employed in polyetherification reaction of 4,4′-dihalodiphenyl sulfones.

Expand 1 Items

4-Bromobenzonitrile

Supplier: Aladdin Scientific

4-Bromobenzonitrile has been used in the synthesis of 4-iodobenzonitrile via photo-induced aromatic Finkelstein iodination reaction. It can also be used as an aryl halide test compound in developing greener reaction conditions for Suzuki cross-coupling between aryl halides and phenyl boronic acid.

Expand 2 Items

3-Cyclohexyl-D-alanine Methyl Ester Hydrochloride

Supplier: Aladdin Scientific

3-Cyclohexyl-D-alanine Methyl Ester Hydrochloride

Expand 4 Items

CYM 5520

Supplier: Aladdin Scientific

CYM-5520 has been used as a sphingosine 1-phosphate receptor 2 (S1pr2) agonist in pancreatic adenocarcinoma cell line (CFPAC-1).Application：CYM-5520 is a specific, noncompetitive allosteric agonist of sphingosine 1-phosphate receptor 2 (S1PR2; EC50 = 1.0 μM). The compound CYM-5520 does not show any agonsit activity towards S1PR1, S1PR3, S1PR4 or S1PR5.CYM-5520 mediates phosphorylation of transcription factor p65. It upregulates trabecular number, thickness as well as tibial bone volume density in osteoblasts.

Expand 4 Items

CK 666

Supplier: Aladdin Scientific

Store at −20 °C. Store under desiccating conditions. The product can be stored for up to 12 months.

Expand 4 Items

5-Chloro-2-iodobenzoic acid

Supplier: Aladdin Scientific

5-Chloro-2-iodobenzoic acid

Expand 2 Items

5-Chloro-1H-pyrrolo[2,3-b]pyridin-4-amine

Supplier: Aladdin Scientific

5-Chloro-1H-pyrrolo[2,3-b]pyridin-4-amine

Expand 1 Items

IGG3 ELISA KIT HUMAN 0.15 NG/ML

Supplier: Novus Biologicals

IGG3 ELISA KIT HUMAN 0.15 NG/ML

Expand 1 Items

Anti-IgA alpha Goat Polyclonal Antibody (Biotin (NHS-LC))

Supplier: Immunoreagents

ImmunoReagents’ Biotinylated antibody conjugates are widely used due to their ability to enhance antibody signal in most immunoassays. Biotinylated secondary antibodies are used in most immunoassay formats (i.e., ELISA, Immunohistochemistry (IHC), and Western blotting). While Biotinylated antibodies by themselves do not produce a signal that can be visualized, biotin has a high affinity and specificity to Streptavidin/Avidin. Using ImmunoReagents’ streptavidin conjugates with biotinylated antibodies results in signal amplification.

Expand 1 Items

Anti-IgA alpha Goat Polyclonal Antibody (DyLight® 800)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 800 conjugates uses a near-IR fluorphore that is invisible to the naked eye but increases the staining options when using infrared imaging systems. DyLight® 800 has spectral properties that are very similar to other near-IR dyes, including Alexa Fluor 790 and IRDye 800, and has high solubility for maximal incorporation of the dye into the biomolecule of interest. Excitation/Emission = 777nm / 794nm Emission Color = Near IR (Similar Dyes: Alexa Fluor 790, IRDye 800)

Expand 1 Items

MT BENZENE 0.15-10 PPM

Supplier: Draeger

MT BENZENE 0.15-10 PPM

Expand 1 Items

A1444854 94994-00-0 250MG

Supplier: Ambeed

A1444854 94994-00-0 250MG

Expand 1 Items

Human Anti-SARS-CoV-2 (S) IgG ELISA Kit

Supplier: Antibodies.com

Human Anti-SARS-CoV-2 (S) IgG ELISA kit is a indirect Enzyme-Linked Immunosorbent Assay designed for the in vitro qualitative determination of human Anti-SARS-CoV-2 (S) IgG in serum, plasma, tissue homogenates, and other biological fluids.