48 Results for: "List Biological Laboratories, Inc."

Supplier: List Biological Laboratories, Inc.

Pasteurella multocida toxin is produced by some strains of Pasteurella multocida, a small gram-negative coccobacillus that is pathogenic for many species of animals

Supplier: List Biological Laboratories, Inc.

Pertussis toxin (PT), a virulence factor produced by Bordetella pertussis, is a multi-subunit toxin which binds to most cultured mammalian cells and targets specific G protein, inhibiting the ability of the G protein to function in signaling pathways

Supplier: List Biological Laboratories, Inc.

Bacillus anthracis is the etiological agent of anthrax

Supplier: List Biological Laboratories, Inc.

Clostridium botulinum neurotoxins (BoNT) are among the most toxic substances known to man

Supplier: List Biological Laboratories, Inc.

Tetanus toxin is a potent neurotoxin that is taken up by presynaptic terminals at the neuromuscular junction, travels retrogradely within motor neurons and is transported transsynaptically to spinal cord interneurons

Supplier: List Biological Laboratories, Inc.

The potent toxicity of both the botulinum neurotoxins and anthrax lethal toxin is due to a zinc-dependent proteolytic activity associated with the toxins.  Measurement of this enzymatic activity provides for both a potentially sensitive and direct means for detection of the toxin, and a method for identifying potential toxin inhibitors using high throughput screening. A highly efficient approach for monitoring enzymatic activity is based on the use of fluorescence resonance energy transfer (FRET) substrates. These fluorogenic peptides contain a donor fluorescent group at one end and a suitable chromogenic acceptor group at the other.  The fluorescence is quenched initially by intramolecular energy transfer between the donor/acceptor pair.  Cleavage of the FRET substrate by the appropriate enzyme releases the fluorophore and full fluorescence is restored.  The increase in fluorescence intensity is directly proportional to the amount of enzyme present.  Enzymatic activity can be monitored continuously by recording the increase in fluorescence intensity with time.  The change in the relative fluorescence units (RFU) as cleavage occurs can be converted to nmoles of cleaved substrate from a standard curve generated using a Calibration Peptide which is the cleaved substrate containing only the N-terminally attached fluorophore.  For Botulinum neurotoxin type A, a Control FRET peptide substrate that is not cleaved by the neurotoxin but contains all remaining non-specific sites in the sequence can be used to screen background cleavage of the substrate that can occur in complex matrices.

Supplier: List Biological Laboratories, Inc.

Supplier: List Biological Laboratories, Inc.

A major nosocomial pathogen, Clostridium difficile causes antibiotic-associated colitis and intestinal inflammatory disease, together called CDI

Supplier: List Biological Laboratories, Inc.

Bacterial lipopolysaccharides have long been recognized as the active component of gram negative bacterial endotoxins

Supplier: List Biological Laboratories, Inc.

Supplier: List Biological Laboratories, Inc.

Supplier: List Biological Laboratories, Inc.

Produced by Vibrio cholerae, cholera toxin (CT) is a multimeric enterotoxin that transfers ADP-ribose to a G protein, locking adenylate cyclase in an 'on' position

Supplier: List Biological Laboratories, Inc.

Corynebacterium diphtheriae is a Gram-positive bacterium which infects epithelial cells of the upper respiratory tract and produces diphtheria toxin

Supplier: List Biological Laboratories, Inc.

Shiga toxin is a group of related toxins produced by Shigella dysenteriae and enterohemorrhagic Escherichia coli (EHEC)

Supplier: List Biological Laboratories, Inc.

ANTIGEN ANTHRAX PROACTIVE F/B ANTHRACIS

Supplier: List Biological Laboratories, Inc.

ANTHRAX PA RE QD VIAL

Supplier: List Biological Laboratories, Inc.

PEPTIDE UNQUENCHED CALIBRATION 50NMOLE

Supplier: List Biological Laboratories, Inc.

CHOLERA TOX QD AZIDE-FREE VIAL

Supplier: List Biological Laboratories, Inc.

TETANUS TOXIN LIGHT CHAIN RE

Supplier: List Biological Laboratories, Inc.

ANTI-BOTULINUM TOXIN A VIAL1

Supplier: List Biological Laboratories, Inc.

ANTHRAX PA RE VIAL1

Supplier: List Biological Laboratories, Inc.

PERTUSSIS TOXIN IN GLYCEROL VIAL1

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ANTHRAX LETHAL FACTOR RE QD VIAL1

Supplier: List Biological Laboratories, Inc.

ANTHRAX PA RE VIAL

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CLOSTRIDIUM DIFF BINARY B SUBUNIT VIAL

Supplier: List Biological Laboratories, Inc.

FILAMENTOUS HEMAGGLUTININ VIAL

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HIGHLY PURIFIED HPT LPS 165 VIAL

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ANTHRAX LETHAL FAC RE NATIVE QD VIAL

Supplier: List Biological Laboratories, Inc.

ANTHRAX LETHAL FACTOR RE QD VIAL

Supplier: List Biological Laboratories, Inc.

LIPID A DI-PHOS K12 D31M4 VIAL