2521 Results for: "Genscript"

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Genscript

Denosumab with trade name Prolia, is an FDA-approved drug for the treatment of patients with osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. Denosumab is a fully human monoclonal antibody that works as a RANK ligand (RANKL) inhibitor. Denosumab can bind RANKL, preventing RANKL from activating RANK, its receptor on the osteoclast surface. Anti-Denosumab Antibody (9A10), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Denosumab.

Supplier: Genscript

Avelumab with trade name Bavencio, is an FDA-approved drug to treat Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by Avelumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as 'immune checkpoint inhibition'.Anti-Avelumab Antibody (12G9), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Avelumab.

Supplier: Genscript

Golimumab with trade name Simponi, is an FDA-approved drug for the treatment of Rheumatoid arthritis (RA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS) and Ulcerative Colitis (UC). It is a human IgG1κ monoclonal antibody that binds to Tumor Necrosis Factor alpha (TNF-alpha), thereby inhibiting the binding to TNF alpha receptors and subsequent generation of inflammatory cytokines. GenScript Anti-Golimumab Antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Golimumab.

Supplier: Genscript

Adeno-associated virus (AAV) is a single-stranded DNA virus that commonly infects humans without pathology. Therefore, AAV can be engineered to deliver DNA to target cells as a vector for gene therapy. There are several serotypes including AAV type 1, 2, 5, 6, 8, 9, DJ and rh.1. Among them, AAV2 is the best characterized and most commonly used. Cap gene of AAV gives rise to three capsid proteins, VP1, VP2 and VP3, with molecular weight of 87, 72 and 62 kDa, respectively. These capsid proteins assemble into a near-spherical protein shell of 60 subunits for AAV.

Supplier: Genscript

Human IgG is the major immunoglobulin in blood and plays a key role in the humoral immune response. The Fc portion of human IgG binds to Fc receptor that can activate the complement system. Fc-tagged proteins are generated with DNA recombinant technology. The protein of interest is fused with the Fc tag. Most vectors encoding for Fc tag sequence use the Fc region of human IgG1. Protein A can be used for the purification of Fc-tagged proteins. Human IgG (Fc), mAb, Mouse is a useful tool for immunoassay of human Fc-tagged proteins and human IgG.GenScript Human IgG (Fc) Antibody, mAb, Mouse is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes obtained from mouse immunized with human Fc-tagged protein.

Supplier: Genscript

Pertuzumab (also called 2C4, trade name Perjeta) is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it is also used in the same combination as a neoadjuvant in early HER2-positive breast cancer. The epitope for pertuzumab is the domain of HER2 where it binds to HER3, and pertuzumab prevents the HER2/HER3 dimer from forming, which in turn blocks signaling by the dimer and as a result prevents HER2 from functioning. Anti-Pertuzumab Antibody (1A3), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Pertuzumab.

Supplier: Genscript

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease in 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells. Lineage B.1.351 (a.k.a. 20H/501Y.V2) is a variant of SARS-CoV-2 (Beta variant). It has multiple mutations in theS1 RBD, including K417N, E484K, N501Y.

Supplier: Genscript

A Camelid VHH Antibody (also called single-domain antibody, sdAb or Nanobody by Ablynx) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody. Like a whole antibody, it is able to bind selectively to a specific antigen. VHH antibodies allow a broad range of applications in biotechnical as well as therapeutic use due to their small size, simple production and high affinity.

Supplier: Genscript

CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. It plays an important role in cell proliferation and cytokine production and promotion of T-cell survival. It also enhances the production of IL-4 and IL-10 in T cells in conjunction with TCR/CD3 ligation and CD40L co-stimulation.

Supplier: Genscript

Ustekinumab with trade name Stelara, is an FDA-approved drug to Crohn's disease, Ulcerative Colitis, Plaque Psoriasis and Psoriatic Arthritis, targeting both interleukins (IL)-12 and IL-23. Ustekinumab is a fully human immunoglobulin G1 kappa mAb that binds to IL-12 and IL-23. Ustekinumab binds to the p40 subunit common to IL-12 and IL-23 and prevents their interaction with the IL-12 receptor β1 subunit of the IL-12 and IL-23 receptor complexes, thereby disrupting the proinflammatory pathway. Anti-Ustekinumab Antibody (9A5), mAb, mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Ustekinumab.

Supplier: Genscript

A Camelid VHH Antibody (also called single-domain antibody, sdAb or Nanobody by Ablynx) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody. Like a whole antibody, it is able to bind selectively to a specific antigen. VHH antibodies allow a broad range of applications in biotechnical as well as therapeutic use due to their small size, simple production and high affinity.

Supplier: Genscript

Ustekinumab with trade name Stelara, is an FDA-approved drug to Crohn's disease, Ulcerative Colitis, Plaque Psoriasis and Psoriatic Arthritis, targeting both interleukins (IL)-12 and IL-23. Ustekinumab is a fully human immunoglobulin G1 kappa mAb that binds to IL-12 and IL-23. Ustekinumab binds to the p40 subunit common to IL-12 and IL-23 and prevents their interaction with the IL-12 receptor β1 subunit of the IL-12 and IL-23 receptor complexes, thereby disrupting the proinflammatory pathway. Anti-Ustekinumab Antibody (11E3), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Ustekinumab.

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Genscript

Adeno-associated virus type 2 (AAV2) is a valuable vector for gene therapy. It is one member of the human parvovirus family which depends on co-infection with helper viruses such as adenovirus or herpes virus for efficient reproduction. AAV2 empty capsids are composed of three proteins, VP1, VP2 and VP3 with relative molecular masses of 87, 72 and 62 kDa respectively.

Supplier: Genscript

Payloads are the important components of antibody-drug conjugates (ADCs). The most commonly used ADC payloads are MMAE, DM1, and DXd. ADC pharmacokinetic (PK) studies include free payload analysis, conjugated antibody analysis, and total antibody analysis via ligand-binding assay (LBA) and LC-MS/MS assay. The anti-payload antibody is a useful reagent in PK assay for determining conjugated antibodies. It can be used as a capture antibody to determine the conjugated antibody in LBA assay or through immunocapture to enrich the ADC sample in LC-MS/MS assay. The DM1, also known as mertansine, is a microtubule polymerization inhibitor. Trastuzumab emtansine (T-DM1), composed of trastuzumab conjugated to DM1, is a type of targeted cancer drug for breast cancer treatment. T-DM1 is targeted toward HER2 (ERBB2) positive breast cancer.

Supplier: Genscript

GenScript offers recombinant protein A with non-essential domains removed, recombinant protein G with albumin binding site deleted as well as codon optimized protein L. By pre-coupling these genetically modified proteins to 4% highly cross-linked agarose, GenScrtipt developed excellent antibody affinity chromatography matrix - Protein A, G and L Resins for batch/gravity purification of polyclonal and monoclonal antibody from cell culture supernatants, serum, and ascites at both laboratory and larger scale. Besides, GenScript provides several affinity resins for convenient and reliable purification of tagged proteins, including His-tagged protein purification resin, GST fusion protein purification resin, DYKDDDDK tagged protein purification resin and Streptavidin resin.

Supplier: Genscript

The product is specific for Nivolumab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01848-40, Anti- Nivolumab Antibody (6G5H2E6), mAb, Mouse.

Supplier: Genscript

GenScript offers a wide selection of Protein molecular weight standards for SDS-PAGE and Western blot, including prestained, unstained, peptide, Western-viewable, and other standards.

Supplier: Genscript

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain.

Supplier: Genscript

The product is specific for Adalimumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01954-40, Anti- Adalimumab Antibody (15C7), mAb, Mouse.

Supplier: Genscript

The product is specific for bevacizumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01975-40, anti-bevacizumab antibody (4H1), mAb, mouse.

Supplier: Genscript

The product is specific for trastuzumab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A02033-40, anti-trastuzumab antibody (15H2), mAb, mouse.

Supplier: Genscript

Rabbit IgG control is suitable for use as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, western blot, immunoprecipitation, immunodiffusion, and immunoelectrophoresis, flow cytometry and immunofluorescence. GenScript MonoRab™ rabbit IgG control [iFluor 647] (whole molecule), mAb is iFluor 647 conjugated MonoRab™ rabbit IgG control (whole molecule), mAb.

Supplier: Genscript

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain.

Supplier: Genscript

GenScript THE™ DYKDDDDK Tag antibody [FITC], mAb, Mouse recognizes C-terminal, N-terminal and internal DYKDDDDK tagged fusion proteins.

Supplier: Genscript

This endotoxin detection system is intended for use as an in vitro end-product endotoxin test for human and animal parenteral drugs, biological products and medical devices.

Supplier: Genscript

Recombinant Enterokinase protein

Supplier: Genscript

HSA Antibody (2C7B4), mAb, Mouse recognizes HSA proteins and it has no cross-reactivity with mouse serum albumin, rabbit serum albumin, BSA and OVA.

Supplier: Genscript

The specificity of the antibody is defined as the ratio of antigen concentration to cross-reactant concentration at 50% inhibition of maximum binding.