2521 Results for: "Genscript"

Supplier: Genscript

The product is specific for Ipilimumab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01858-40, Anti- Ipilimumab Antibody (4H6E1D4), mAb, Mouse.

Supplier: Genscript

GenScript SUMO-tag antibody (4G11E9), mAb, Mouse specifically reacts with fusion proteins containing SUMO epitope tags.

Supplier: Genscript

Ustekinumab with trade name Stelara, is an FDA-approved drug to Crohn's disease, Ulcerative Colitis, Plaque Psoriasis and Psoriatic Arthritis, targeting both interleukins (IL)-12 and IL-23. Ustekinumab is a fully human immunoglobulin G1 kappa mAb that binds to IL-12 and IL-23. Ustekinumab binds to the p40 subunit common to IL-12 and IL-23 and prevents their interaction with the IL-12 receptor β1 subunit of the IL-12 and IL-23 receptor complexes, thereby disrupting the proinflammatory pathway. GenScript Anti-Ustekinumab Antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Ustekinumab.

Supplier: Genscript

Etanercept with trade name Enbrel, is an FDA-approved drug to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. Etanercept is a fusion protein made from the combination of two naturally occurring soluble human 75-kilodalton TNF receptors linked to an Fc portion of an IgG1. Etanercept treats autoimmune diseases by interfering with tumor necrosis factor-alpha (TNF alpha, a soluble inflammatory cytokine) by acting as a TNFalpha inhibitor.Anti-Etanercept Antibody (4H5), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Etanercept.

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Genscript

Eculizumab with trade name Soliris, is an FDA-approved drug to treat paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and neuromyelitis optica. Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5. Eculizumab specifically binds to the terminal complement component 5, or C5. Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions. Anti-Eculizumab Antibody (4F6), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Eculizumab.

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Genscript

Palivizumab with trade name Synagis, is an FDA-approved drug for the prevention of respiratory syncytial virus (RSV) infections. It is a recombinant humanized IgG1 kappa isotype monoclonal antibody. Palivizumab binds the RSV envelope fusion protein (RSV F) on the surface of the virus and blocking a critical step in the membrane fusion process. Anti-Palivizumab Antibody (2F12), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Palivizumab.

Supplier: Genscript

GenScript THE™ His Tag antibody [Biotin], mAb, Mouse specificly recognizes C-terminal, N-terminal and internal His tagged fusion proteins.

Supplier: Genscript

GenScript's Bis-Tris gels are high-performing polyacrylamide gels designed to separate a wide range of protein sizes by electrophoresis. The gels are cast in a neutral pH buffer that minimizes polyacrylamide hydrolysis and increases gel stability. Furthermore, the neutral pH which minimizes protein modification when compared to Tris-glycine gels.

Supplier: Genscript

The product is specific for Pembrolizumab.

Supplier: Genscript

THE™ NWSHPQFEK Tag antibody [Biotin], mAb, Mouse recognizes N-terminal and C-terminal Strep II tagged fusion proteins.

Supplier: Genscript

GenCrispr NLS-Cas9-EGFP is a fusion protein, contains a nuclear localization signal (NLS) on its N terminal end, and an EGFP and a 6x(His) sequence on the C terminal end. Cas9 nuclease is an RNA-guided endonuclease that can catalyze cleavage of double stranded DNA. This kind of targeted nuclease is a powerful tool for genome editing with high precision.

Supplier: Genscript

The product is specific for sarilumab.

Supplier: Genscript

4X LDS Sample Buffer used to prepare protein samples for denaturing polyacrylamide gel electrophores (PAGE) with SurePAGE*, ExpressPlus* most other types of Bis-Tr gels. LDS sample buffer contains lithium dodecyl sulfate with pH at 8.4, which helps reducing disulfide bonds ensure, Size: 10ml

Supplier: Genscript

The product is specific for SARS-CoV-2 Nucleocapsid protein.

Supplier: Genscript

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain. The product can recognize and neutralize Wild-Type SARS-CoV-2 and five Variants of Concern (VOC) including Alpha, Beta, Gamma, Delta, and Omicron.

Supplier: Genscript

This antibody recognizes c-Myc tagged fusion proteins.

Supplier: Genscript

The product is specific for Rituximab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01942-40, MonoRab™ Anti-Rituximab Antibody (137C6), mAb, Rabbit.

Supplier: Genscript

The product is specific for Rituximab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01969-40, Anti-Rituximab Antibody (6C1), mAb, Mouse.

Supplier: Genscript

The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A02008-40, MonoRab™ anti-pembrolizumab antibody (94B9), mAb, rabbit.

Supplier: Genscript

The product is specific for tocilizumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01978-40, anti-tocilizumab antibody (14B10), mAb, mouse.

Supplier: Genscript

Rabbit IgG control is suitable for use as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, western blot, immunoprecipitation, immunodiffusion, and immunoelectrophoresis, flow cytometry and immunofluorescence. GenScript MonoRab™ rabbit IgG control [PE] (whole molecule), mAb is PE conjugated MonoRab™ rabbit IgG control (whole molecule), mAb.

Supplier: Genscript

The product is specific for Adalimumab. This antibody blocks Adalimumab binding with TNF-α (Z01001, TNF-α, Human) in ELISA. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01921-40, MonoRab™ Anti-Adalimumab Antibody (4E12), mAb, Rabbit.

Supplier: Genscript

GenScript MonoRab™ DYKDDDDK tag antibody [HRP], mAb, rabbit specifically recognizes DYKDDDDK tags placed at C-terminal, N-terminal and internal regions of DYKDDDDK fusion proteins.

Supplier: Genscript

GenScript MonoRab™ Rabbit Anti-Camelid VHH Antibody [iFluor488], mAb is specific for Camelid VHH Antibody (Alpaca, Llama and Camel). The monoclonal antibody has no cross-reactivity with mouse, rat, rabbit, chicken, goat or human immunoglobulins.

Supplier: Genscript

The product is specific for Bevacizumab but can't block vascular endothelial growth factor 165 (VEGF 165). The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01896-40, MonoRabTM Anti- Bevacizumab Antibody (46E3)[Biotin], mAb, Rabbit.

Supplier: Genscript

GenScript MonoRab™ Rabbit Anti-Camelid VHH Antibody [iFluor555], mAb is specific for Camelid VHH antibody (Alpaca, Llama and Camel). The monoclonal antibody has no cross-reactivity with mouse, rat, rabbit, chicken, goat or human immunoglobulins.

Supplier: Genscript

CD4 (cluster of differentiation 4) is a single glycoprotein with a molecular weight of 59 kDa. CD4 antigen is expressed on the surface of T helper cells, monocytes and macrophages. CD4 recognizes antigens associated with MHC class II molecules, and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4+ T helper cells bind and activate B cells to create immunoglobulins.

Supplier: Genscript

Omalizumab with trade name Xolair, is an FDA-approved drug for the treatment of moderate to severe persistent asthma in adults and adolescents (12 years of age and above). It is a recombinant humanized monoclonal antibody. It selectively binds to human immunoglobulin E (IgE). Omalizumab inhibits the binding of IgE to the high-affinity IgE receptor (FcεRI) on the surface of mast cells and basophils. Anti-Omalizumab Antibody (10G3), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Omalizumab.