2537 Results for: "Genscript"

Supplier: Genscript

The product is specific for durvalumab.

Supplier: Genscript

Denosumab with trade name Prolia, is an FDA-approved drug for the treatment of patients with osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. Denosumab is a fully human monoclonal antibody that works as a RANK ligand (RANKL) inhibitor. Denosumab can bind RANKL, preventing RANKL from activating RANK, its receptor on the osteoclast surface. Anti-Denosumab Antibody (9A10), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Denosumab.

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Genscript

The product is specific for Cetuximab. This antibody blocks Cetuximab binding with EGFR (Z03202, EGFR, His, Human) in ELISA. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01939-40, Anti-Cetuximab Antibody (20H1), mAb, Mouse.

Supplier: Genscript

Immunoglobulin M (IgM) is one of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates. IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antigen. Formed from covalently linking 5 immunoglobulins together. Anti-human IgM mu chain antibody is ideal for investigators in Immunology, Microbiology, and Cell Biology.

Supplier: Genscript

GenScript Anti-E-tag [HRP] Polyclonal antibody recognizes E tagged fusion proteins.

Supplier: Genscript

THE™ GST antibody [Biotin], mAb, Mouse recognizes C-terminal, N-terminal and internal tagged GST fusion proteins.

Supplier: Genscript

Adeno-associated virus (AAV) is a single-stranded DNA virus that commonly infects humans without pathology. Therefore, AAV can be engineered to deliver DNA to target cells as a vector for gene therapy. There are several serotypes including AAV type 1, 2, 5, 6, 8, 9, DJ and rh.1. Among them, AAV2 is the best characterized and most commonly used. Cap gene of AAV gives rise to three capsid proteins, VP1, VP2 and VP3, with molecular weight of 87, 72 and 62 kDa, respectively. These capsid proteins assemble into a near-spherical protein shell of 60 subunits for AAV.

Supplier: Genscript

GenScript Purified Rabbit IgG (Whole Molecule) Control is highly purified from normal rabbit serum by Protein G chromatography.GenScript Purified Rabbit IgG (Whole Molecule) Control is suitable for use as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, immunobloting (Dot blot and Western blot), immunoprecipitation, immunodiffusion, and immunoelectrophoresis.It also may be used as antigen or ligand in immunochemical reactions and conjugations.

Supplier: Genscript

eZwest™ Lite is a fully automated western blotting device completing the entire process of blocking, antibody incubation, and washing steps. Automation of western blot incubation steps minimizes errors and variability typically associated with manual operations contributing to experimental reproducibility. eZwest frees researchers from the manual labor of traditional western blot.

Supplier: Genscript

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells.SARS-CoV-2 Neutralizing Antibody (R323IgM), Human Chimeric is produced from cell culture in vitro under conditions free from animal-derived components.

Supplier: Genscript

Sarilumab with the trade name of Kevzara, is a human monoclonal IgG1 antibody. It binds to membrane bound and soluble interleukin 6 (IL-6) receptor forms. It was FDA-approved in for the treatment of Rheumatoid Arthritis (RA) in combination with methotrexate. GenScript anti-sarilumab antibody, pAb, rabbit is produced from sera of a rabbit immunized with Sarilumab.

Supplier: Genscript

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells. Lineage B.1.617 has the double mutations E484Q and L452R in the spike proteins.

Supplier: Genscript

Pertuzumab (also called 2C4, trade name Perjeta) is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer. The epitope for pertuzumab is the domain of HER2 where it binds to HER3, and pertuzumab prevents the HER2/HER3 dimer from forming, which blocks signalling by the dimer to prevent HER2 from functioning. Anti-Pertuzumab antibody (11H4), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Pertuzumab.

Supplier: Genscript

Panitumumab with trade name Vectibix, is an FDA-approved drug for the treatment of patients with EGFR-expressing metastatic colorectal carcinoma with non-mutated (wild-type) KRAS after failure of fluoropyrimidine-, oxaliplatin- and irinotecan-containing chemotherapy regimens. It is a human monoclonal antibody. Panitumumab binds to the human EGF receptor (EGFR), preventing binding of activating ligands, such as the EGF and transforming growth factor-alpha. Anti-Panitumumab Antibody (2E7), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Panitumumab.

Supplier: Genscript

To enable fast and efficient purification of antibody and epitope-tagged proteins, GenScript provides super paramagnetic magnetic beads. GenScript magnetic beads are coated with recombinant protein ligands that enable highly specific affinity binding to antibodies and epitope-tagged proteins.

Supplier: Genscript

Genscript ToxinSensorTM Chromogenic LAL Endotoxin Assay Kit is designed to be a quantitative In Vitro end-point endotoxin test for human and animal parenteral drugs, biological products, and medical devices.

Supplier: Genscript

THE™ Anti-GST Monoclonal antibody (Mouse) recognizes GST localized at the C-terminal, N-terminal and internal region ofGST-tagged fusion proteins.

Supplier: Genscript

The product is specific for SARS-CoV-2 Nucleocapsid protein.

Supplier: Genscript

The MonoRab™ Rabbit Anti-Camelid VHH Antibody [iFluor 647], mAb is specific for Camelid VHH (Alpaca, Llama and Camel). This monoclonal antibody has no cross-reactivity with mouse, rat, rabbit, chicken, goat or human immunoglobulins.

Supplier: Genscript

THE™ HA Tag antibody [HRP], mAb, Mouse recognizes C-terminal, N-terminal and internal HA tagged fusion proteins.

Supplier: Genscript

THE™ V5 Tag antibody, mAb, Mouse recognizes C-terminal, N-terminal and internal V5 tagged fusion proteins.

Supplier: Genscript

THE™ NWSHPQFEK Tag antibody [FITC], mAb, Mouse recognizes N-terminal and C-terminal Strep II tagged fusion proteins.

Supplier: Genscript

GenScript His-tag antibody [Biotin], pAb, Rabbit specifically reacts with fusion proteins containing His tagged fusion proteins.

Supplier: Genscript

The product is specific for SARS-CoV-2 spike protein S1 subunit and its RBD domain.

Supplier: Genscript

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease in 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells. Lineage B.1.351 (a.k.a. 20H/501Y.V2) is a variant of SARS-CoV-2. It has multiple mutations in the RBD, including K417N, E484K, N501Y. Lineage B.1.1.7 (a.k.a. 20I/501Y.V1) is also a variant of SARS-CoV-2 and has a mutation called N501Y in the RBD.SARS-CoV-2 Spike (E484) Neutralizing Antibody (COV2109) is produced from cell culture in vitro under conditions free from animal-derived components. The product is a humanized neutralizing antibody, recognizing E484 site of wild-type RBD. When E484 is mutated to E484K, the mutant RBD, such as RBD (B.1.351) as seen in Figure 1, can’t be recognized by the product.

Supplier: Genscript

The product is specific for Tocilizumab. This antibody serves as an excellent positive control for Tocilizumab immunogenicity (ADA) assays.

Supplier: Genscript

THE™ DYKDDDDK Tag antibody [HRP], mAb, Mouse recognizes C-terminal, N-terminal and internal tagged fusion proteins.

Supplier: Genscript

GenScript Purified Mouse IgG (Whole Molecule) Control is highly purified from normal mouse serum through Protein A chromatography.GenScript Purified Mouse IgG (Whole Molecule) Control is suitable to be used as control, standard, blocking agent, or coating protein in a variety of assays, including ELISA, immunobloting (Dot blot and Western blot), immunoprecipitation, immunodiffusion, and immunoelectrophoresis.It may also be used as antigen or ligand in immunochemical conjugation reaction.

Supplier: Genscript

SARS-CoV-2 ADE-causing antibody is a SARS-CoV-2 Spike protein antibody that can exacerbate the COVID-19 disease severity of patients. Antibody-dependent enhancement (ADE) may be involved in the clinical observation of patients with increased severity of symptoms and high levels of SARS-CoV-2 antibodies. It is reported [1] that the same antibodies against the NTD domain of the SARS-CoV-2 spike protein have an ADE effect by increasing the binding of ACE2 to the spike protein.