"Genscript"

Supplier: Genscript

GenScript offers recombinant protein A with non-essential domains removed, recombinant protein G with albumin binding site deleted as well as codon optimized protein L. By pre-coupling these genetically modified proteins to 4% highly cross-linked agarose, GenScrtipt developed excellent antibody affinity chromatography matrix - Protein A, G and L Resins for batch/gravity purification of polyclonal and monoclonal antibody from cell culture supernatants, serum, and ascites at both laboratory and larger scale. Besides, GenScript provides several affinity resins for convenient and reliable purification of tagged proteins, including His-tagged protein purification resin, GST fusion protein purification resin, DYKDDDDK tagged protein purification resin and Streptavidin resin.

Supplier: Genscript

This endotoxin detection system is intended for use as an in vitro end-product endotoxin test for human and animal parenteral drugs, biological products and medical devices.

Supplier: Genscript

CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. It plays an important role in cell proliferation and cytokine production and promotion of T-cell survival. It also enhances the production of IL-4 and IL-10 in T cells in conjunction with TCR/CD3 ligation and CD40L co-stimulation.

Supplier: Genscript

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain.

Supplier: Genscript

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease in 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells. Lineage B.1.351 (a.k.a. 20H/501Y.V2) is a variant of SARS-CoV-2 (Beta variant). It has multiple mutations in theS1 RBD, including K417N, E484K, N501Y.

Supplier: Genscript

Payloads are the important components of antibody-drug conjugates (ADCs). The most commonly used ADC payloads are MMAE, DM1, and DXd. ADC pharmacokinetic (PK) studies include free payload analysis, conjugated antibody analysis, and total antibody analysis via ligand-binding assay (LBA) and LC-MS/MS assay. The anti-payload antibody is a useful reagent in PK assay for determining conjugated antibodies. It can be used as a capture antibody to determine the conjugated antibody in LBA assay or through immunocapture to enrich the ADC sample in LC-MS/MS assay. The DM1, also known as mertansine, is a microtubule polymerization inhibitor. Trastuzumab emtansine (T-DM1), composed of trastuzumab conjugated to DM1, is a type of targeted cancer drug for breast cancer treatment. T-DM1 is targeted toward HER2 (ERBB2) positive breast cancer.

Supplier: Genscript

The product is specific for trastuzumab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A02033-40, anti-trastuzumab antibody (15H2), mAb, mouse.

Supplier: Genscript

A Camelid VHH Antibody (also called single-domain antibody, sdAb or Nanobody by Ablynx) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody. Like a whole antibody, it is able to bind selectively to a specific antigen. VHH antibodies allow a broad range of applications in biotechnical as well as therapeutic use due to their small size, simple production and high affinity.

Supplier: Genscript

Ustekinumab with trade name Stelara, is an FDA-approved drug to Crohn's disease, Ulcerative Colitis, Plaque Psoriasis and Psoriatic Arthritis, targeting both interleukins (IL)-12 and IL-23. Ustekinumab is a fully human immunoglobulin G1 kappa mAb that binds to IL-12 and IL-23. Ustekinumab binds to the p40 subunit common to IL-12 and IL-23 and prevents their interaction with the IL-12 receptor β1 subunit of the IL-12 and IL-23 receptor complexes, thereby disrupting the proinflammatory pathway. Anti-Ustekinumab Antibody (9A5), mAb, mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Ustekinumab.

Supplier: Genscript

A Camelid VHH Antibody (also called single-domain antibody, sdAb or Nanobody by Ablynx) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody. Like a whole antibody, it is able to bind selectively to a specific antigen. VHH antibodies allow a broad range of applications in biotechnical as well as therapeutic use due to their small size, simple production and high affinity.

Supplier: Genscript

The product is specific for Nivolumab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01848-40, Anti- Nivolumab Antibody (6G5H2E6), mAb, Mouse.

Supplier: Genscript

The product is specific for SARS-CoV-2 Spike Protein S1 subunit and its RBD domain.

Supplier: Genscript

The product is specific for Adalimumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01954-40, Anti- Adalimumab Antibody (15C7), mAb, Mouse.

Supplier: Genscript

GenScript offers a wide selection of Protein molecular weight standards for SDS-PAGE and Western blot, including prestained, unstained, peptide, Western-viewable, and other standards.

Supplier: Genscript

Adeno-associated virus type 2 (AAV2) is a valuable vector for gene therapy. It is one member of the human parvovirus family which depends on co-infection with helper viruses such as adenovirus or herpes virus for efficient reproduction. AAV2 empty capsids are composed of three proteins, VP1, VP2 and VP3 with relative molecular masses of 87, 72 and 62 kDa respectively.

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.