2521 Results for: "Genscript"

Supplier: Genscript

SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), also known as 2019-nCoV, is a positive-sense single-stranded RNA virus. It caused coronavirus disease in 2019 (COVID-19). SARS-CoV-2 contains glycosylated spike (S) protein, which is composed of S1 subunit and S2 subunit. The S1 contains a receptor-binding domain (RBD) that can bind to ACE2 receptor on target cells. Lineage B.1.351 (a.k.a. 20H/501Y.V2) is a variant of SARS-CoV-2. It has multiple mutations in the RBD, including K417N, E484K, N501Y. Lineage B.1.1.7 (a.k.a. 20I/501Y.V1) is also a variant of SARS-CoV-2 and has a mutation called N501Y in the RBD.SARS-CoV-2 Spike (N501) neutralizing antibody (COV2110) is produced from cell culture in vitro under conditions free from animal-derived components. The product is a humanized neutralizing antibody, recognizing N501 site of wild-type RBD. When N501 is mutated to N501Y, the mutant RBD, such as RBD (B.1.1.7) and RBD (B.1.351) as seen in Figure 1, can't be recognized by the product.

Supplier: Genscript

Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. It regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat. Proinsulin is the prohormone precursor to insulin made in pancreas. It is processed by a series of proteases to form mature insulin. Mature insulin has 35 fewer amino acids; 4 are removed altogether, and the remaining 31 form the C-Peptide. The C-Peptide is abstracted from the center of the proinsulin sequence; the two other ends (alpha and β chains) remain connected by disulfide bonds. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma. GenScript Insulin Antibody (6E9F1), mAb, Mouse is produced from the hybridoma resulting from fusion of SP2/0-Ag14 myeloma and B-lymphocytes obtained from mouse immunized with human recombinant Insulin expressed in yeast.

Supplier: Genscript

Payloads are the important components of antibody-drug conjugates (ADCs). The most commonly used ADC payloads are MMAE, DM1, and DXd. ADC pharmacokinetic (PK) studies include free payload analysis, conjugated antibody analysis, and total antibody analysis via ligand-binding assay (LBA) and LC-MS/MS assay. The anti-payload antibody is a useful reagent in PK assay for determining conjugated antibodies. It can be used as a capture antibody to determine the conjugated antibody in LBA assay or through immunocapture to enrich the ADC sample in LC-MS/MS assay. The DXd, also known as exatecan derivative, is a potent inhibitor of DNA topoisomerase I. Trastuzumab deruxtecan (T-DXd, DS-8201a or Enhertu®), composed of trastuzumab conjugated to DXd, is the first approved ADC for the treatment of breast cancer.

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx) is a peptide chain about 110 amino acids long comprising one variable domain of a heavy-chain antibody (VHH fragment). Like a whole antibody, a single-domain antibody is able to bind selectively to a specific antigen. Such antibodies allow a broad range of applications in biotechnical as well as therapeutic fields due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and cause anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Genscript

Panitumumab with trade name Vectibix, is an FDA-approved drug for the treatment of patients with EGFR-expressing metastatic colorectal carcinoma with non-mutated (wild-type) KRAS after failure of fluoropyrimidine-, oxaliplatin- and irinotecan-containing chemotherapy regimens. It is a human monoclonal antibody. Panitumumab binds to the human EGF receptor (EGFR), preventing binding of activating ligands, such as the EGF and transforming growth factor alpha. GenScript anti-panitumumab antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Panitumumab.

Supplier: Genscript

Vascular endothelial growth factor (VEGF) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, Vascular endothelial growth factor (VEGF) plays a prominent role in normal and pathological angiogenesis.

Supplier: Genscript

This antibody recognizes strep-tag II tagged fusion proteins.

Supplier: Genscript

The product is specific for SARS-CoV-2 spike protein S1 subunit and its RBD domain.

Supplier: Genscript

The product is specific for SARS-CoV-2 spike protein S1 subunit and its RBD domain.

Supplier: Genscript

MonoRab™ HA tag antibody recognizes HA tags placed at N-terminal, C-terminal, and internal regions of fusion proteins.

Supplier: Genscript

The product is specific for ranibizumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A02035-40, anti-ranibizumab antibody (6C3), mAb, mouse.

Supplier: Genscript

The product is specific for trastuzumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A02032-40 anti-trastuzumab antibody (11C4), mAb, mouse.

Supplier: Genscript

The antibody is recommended as detection antibody in a pharmacokinetic (PK) bridging assay with captrue antibody GenScript, A01984-40, MonoRab anti-atezolizumab antibody (55D8), mAb, rabbit.

Supplier: Genscript

The product is specific for Nivolumab. This antibody serves as an excellent positive control for Nivolumab immunogenicity (ADA) assays.

Supplier: Genscript

GenScript MonoRab™ Rabbit Anti-Camelid VHH Cocktail [iFluor 488] is specific for Camelid VHH antibody (Llama, Alpaca and Camel). It has no cross-reactivity with mouse, rat, rabbit, goat or human immunoglobulins.

Supplier: Genscript

GenScript THE™ His Tag antibody [FITC], mAb, Mouserecognizes C-terminal, N-terminal and internal His tagged fusion proteins.

Supplier: Genscript

THE™ His Tag antibody [HRP], mAb, Mouse recognizes His tags localized at C-terminal, N-terminal and internal region of fusion proteins

Supplier: Genscript

THE™ DYKDDDDK Tag antibody [Biotin], mAb, Mouse recognizes C-terminal, N-terminal and internal tagged fusion proteins.

Supplier: Genscript

GenScript THE™ HA Tag antibody [FITC], mAb, Mouse recognizes C-terminal, N-terminal and internal HA tagged fusion proteins.

Supplier: Genscript

THE™ beta Actin Antibody [HRP], mAb, Mouse reacts with mouse, rabbit, chicken, human, hamster, cow, goat, fish, and pig substrates.It has not yet been tested in other species.

Supplier: Genscript

The product is specific for human PD-1 (UniProt Accession: Q15116). This antibody blocks human PD-L1 binding with human PD-1 expression cell line in flow cytometry assay.

Supplier: Genscript

GenScript MonoRab™ Rabbit Anti-Camelid VHH Antibody [HRP], mAb is specific for Camelid sdAb (Alpaca, Llama and Camel). The monoclonal antibody has no cross-reactivity with mouse, rat, rabbit, chicken, goat or human immunoglobulins.

Supplier: Genscript

GenScript’s MonoRab™ Rabbit Anti-Camelid VHH Cocktail is specific for Camelid VHH antibody (Llama, Alpaca, and Camel). It has no cross-reactivity with mouse, rat, rabbit, goat or human immunoglobulins.

Supplier: Genscript

The product is specific for Rituximab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01942-40, MonoRab™ Anti-Rituximab Antibody (137C6), mAb, Rabbit.

Supplier: Genscript

Secukinumab with brand name Cosentyx, is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is marketed by Novartis for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. Secukinumab inhibits a member of the cytokine family, interleukin 17A, which is produced mainly by inflammatory T helper 17 cells. IL17A is upregulated in serum of people with psoriasis and in the synovial fluid of people with psoriatic arthritis, and promotes inflammation when it binds to the interleukin-17 receptor. Anti-Secukinumab Antibody (23E11), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Secukinumab.

Supplier: Genscript

eBlot™ L1 wet protein transfer system is a fast western blotting protein transfer system that combines the high reproducibility and efficiency of the traditional wet protein transfer with the speed and convenience of semi-dry protein transfer. It allows efficient western blot transfer of small, medium, and large molecular weight proteins.

Supplier: Genscript

Bevacizumab (Avastin) is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of a number of types of cancers and a specific eye disease. Bevacizumab binds to a continuous epitope in VEGF, preventing interaction of VEGF with VEGFR on the surface of endothelial cells. It can be used to inhibit solid tumours growth and metastasis by weakening tumour angiogenesis.

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Genscript

Adeno-associated virus (AAV) is a single-stranded DNA virus that commonly infects humans without pathology. Therefore, AAV can be engineered to deliver DNA to target cells as a vector for gene therapy. There are several serotypes including AAV type 1, 2, 5, 6, 8, 9, DJ and rh.1. Among them, AAV2 is the best characterized and most commonly used. Cap gene of AAV gives rise to three capsid proteins, VP1, VP2 and VP3, with molecular weight of 87, 72 and 62 kDa respectively. These capsid proteins assemble into a near-spherical protein shell of 60 subunits for AAV.

Supplier: Genscript

Secukinumab with brand name Cosentyx, is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is marketed by novartis for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. Secukinumab inhibits a member of the cytokine family, interleukin 17A, which is produced mainly by inflammatory T helper 17 cells. IL17A is upregulated in serum of people with psoriasis and in the synovial fluid of people with psoriatic arthritis, and promotes inflammation when it binds to the interleukin-17 receptor. Anti-Secukinumab antibody (23E11), mAb, mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Secukinumab.