37773 Results for: "Controllers&pageNo=12&view=easy"

Supplier: Bioss

May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

Supplier: Prosci

NALP12 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

Supplier: Rockland Immunochemical

Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.

Supplier: Enzo Life Sciences

Capases are a highly conserved family of cysteine proteases and are synthesized as inactive zymogens, which are cleaved at Asp-x sites during apoptosis, generating large and small subunits that heterodimerize to form the active enzyme. Caspase-1 is a member of the ICE/CED-3 family of caspases and is detected in the pro-form as a protein of 45 kDa.
Caspase-1 generates the bioactive form of the pro-inflammatory cytokine IL-1β from its biologically inactive precursor. Overexpression of caspase-1 in cells induces apoptosis, which can be inhibited by cytokine response modifier A (CrmA). Caspase-1 mRNA is predominantly expressed in the spleen and lung and to a lesser extent in skeletal muscle, kidney, testis and heart and within these tissues macrophages preferentially express caspase-1. Caspase-1 deficient mice have no gross abnormalities, however, macrophages from caspase-1-deficient mice are defective in IL-β processing and release.

Supplier: G-Biosciences

G-Biosciences' Coomassie Brilliant Blue (CBB) G-250 and R-250 Stain are based on a colloidal Coomassie stain. CBB G-250 and R-250 stain proteins with high band visibility. The staining of gels with CBB G-250 and R-250 allows the examination of protein bands even during the staining process.

Supplier: Leica Microsystems

The Leica Microsystems Emspira 3 digital microscope is a cutting-edge tool for precision inspection. With advanced digital capabilities and high-quality imaging, it offers detailed visualisations. Elevate your inspection workflow with this user-friendly and versatile microscope.

Supplier: Electron Microscopy Sciences

The METALTHIN Twin-Jet Electropolisher was originally developed for producing high quality thin foils from radioactive materials. It is robust, compact, economical and easy to use. The electrolyte tank, sample holder, thinning cell and tank base stand are machined from solid PVC to provide maximum resistance to corrosive electrolytes. The Cell parts are held together by stainless steel screws so that the Cell is easy to disassemble.

Supplier: Cytiva

The illustra™ triplePrep Kit is designed for the rapid, simultaneous extraction and isolation of high yield genomic DNA (gDNA), total RNA, and total denatured proteins from undivided animal tissues and mammalian cells. The streamlined workflow reduces the overall number of steps, enabling the preparation of all three analytes in less than one hour.

Supplier: VWR International

Barometric pressure datalogging device that can be used in 21 CFR 11 environments. Used in manufacturing, labs, and all other environments where there is a need to monitor conditions of environmental air parameters.

Supplier: Eppendorf

The all-in-one for heating/cooling and mixing samples and reactions. The Eppendorf® ThermoMixer C convinces users with its quick and easy-to-exchange SmartBlocks for all common laboratory vessels. There is almost no limit to the variety of applications waiting for you.

Supplier: PEAK SCIENTIFIC MS

The Precision Nitrogen Trace 600 and 1000 have been developed to provide a constant and consistent source of nitrogen for carrier, make-up and reference gas at trace detection levels for GC applications as well as for sample preparation.

Supplier: ROEMER INDUSTRIES, INC.

PharmaRoam25 is a medical-grade, countertop refrigerator or freezer that has optional accessories such as battery power and data management. Designed to transport vaccines and pharmaceuticals, units function as refrigerators or freezers down to 1 °C (optional -20 °C with refrigerant change) and run on a battery while on the move. These units can be secured with a padlock, have handles on the sides and can be stacked with stacking corners. Excellent for disaster preparedness to store temperature sensitive products when the electrical power supply is not reliable or dependable.

Supplier: Eppendorf

Centrifuge 5425 and refrigerated 5425 R, feature ergonomic operation and six rotors with a maximum speed of up to 21300 ×g, covering all molecular biological applications in tubes from 0.2 to 5 ml. For temperature-sensitive samples, the refrigerated centrifuge 5425 R provides precise temperature control.

Supplier: GILSON, INC.

The PIPETMAN® L Fixed pipettes offer the same comfortable, lightweight design as the variable volume models with a fixed volume that reduces the risk of any volume error during pipetting. This makes them an ideal choice for clinical diagnostics, quality control, and any routine testing applications even for non-trained lab technicians.

Supplier: Prosci

LMIR1, also termed CD300a, is a type I transmembrane glycoprotein with a single IgV-like extracellular domain and an extended membrane proximal region that links the immunoglobulin (Ig) and transmembrane domains and belongs to the immunoglobulin superfamily. The intracellular domain of LMIR1 contains several immunoreceptor tyrosine-based inhibition motifs (ITIMs). When cross-linked, it will be tyrosine phosphorylated and capable of recruiting tyrosine phosphatases (SHP-1, SHP-2) and inositol polyphosphate 5-phosphatase, SHIP. LMIR1 will regulate mast cell-mediated inflammatory responses. LMIR1 is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type.

Supplier: National Public Seating

NPS wood frame science table is an asset to any lab or classroom. The 24×72" phenolic top can withstand various chemicals. Rubber footing and adjustable glides protect floors and allow for accurate leveling. Book compartments are an added feature for storage.

Supplier: SARSTEDT INC

With our proven, high-quality tips you can expect maximum precision, sophisticated design and the highest purity. We guarantee highly transparent material, clear filling level rings and precise attachment of the pipette cone. The innovative and flexible refill system ensures resource-savings and reliability.

Supplier: Promega Corporation

The HaloTag Technology enables covalent protein labeling and immobilization in vivo and in vitro.

Supplier: Promega Corporation

The HaloTag Technology enables covalent protein labeling and immobilization in vivo and in vitro.

Supplier: Spectrum Chemical Mfg. Corp.

Sodium Citrate, Dihydrate, Granular, FCC is used as a flavorant and preservative. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Supplier: Biotium

Calgranulin B / MRP-8/-14 Monoclonal antibody, Clone: MAC387, Host: Mouse, Species reactivity: Monkey, Goat, Baboon, Pig, Dog, Cow, Cat, Rat, Human, Isotype: IgG1, K, Conjugate: CF594, Synonyms: MAC 387 / S100A8/A9 / Macrophage Ag, Size: 100uL

Supplier: Molecular Devices

FlexStation® 3 Benchtop Multi-Mode Microplate Reader combines Molecular Devices’ SpectraMax® M5e Multi-Mode Microplate Reader performance with an integrated 8- or 16-channel pipettor into one compact benchtop reader.

Supplier: Promega Corporation

The HaloTag Technology enables covalent protein labeling and immobilization in vivo and in vitro.

Supplier: Bel-Art Products, a Part of SP

Made from optical quality polycarbonate plastic material, these plain form hydrometers are durable and shatterproof making them ideal in situations where rough handling or contamination could be an issue, such as in the food or beverage industries.

Supplier: ROEMER INDUSTRIES, INC.

PharmaRoam60 is a medical-grade, countertop refrigerator or freezer that has optional accessories such as battery power and data management. Designed to transport vaccines and pharmaceuticals, units function as refrigerators or freezers down to 1 °C (optional −20 °C with refrigerant change) and run on a battery while on the move. These units can be secured with a padlock, have handles on the side and can be stacked with stacking corners. Excellent for disaster preparedness to store temperature sensitive products when the electrical power supply is not reliable or dependable.

Supplier: Promega Corporation

The HaloTag Technology enables covalent protein labeling and immobilization in vivo and in vitro.

Supplier: Rockland Immunochemical

HIG1 and HIG2 (Hypoxia-inducible gene 1 and 2, respectively) are known to be induced by hypoxic conditions. HIG2 is induced by hypoxia and by glucose deprivation in cultured cells. In addition, tumor xenografts derived from human cervical cancer cells display increased expression of HIG1 and HIG2 when they are deprived of oxygen. Unlike HIG2, which is ubiquitously expressed and might be an activator and target of the canonical Wnt pathway, the function and the mechanisms underlying its regulation of HIG1 still remained unknown. The putative link between hypoxia and an oncogenic signaling pathway might play an important role in tumorigenesis.

Supplier: Prosci

TWEAK Antibody: TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

Supplier: Rockland Immunochemical

TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.

Supplier: WORLD PRECISION INSTRUMENTS LLC

The A385 is an optically isolated current source, which can generate up to 100 mA of unipolar or biphasic constant current pulses or DC. Pulse duration is controlled manually or by an external 5 V command. Output current amplitude is determined by a 3-digit 10-turn potentiometer. Maximum output voltage between the stimulating electrodes is +36 V.