687 Results for: "Cayman Chemical Company"

Supplier: Cayman Chemical Company

A Certified Reference Material

Supplier: Cayman Chemical Company

A Certified Reference Material

Supplier: Cayman Chemical Company

bis-ANS is a high-affinity non-covalent extrinsic fluorescent dye used to analyze protein conformation. Its predominant interaction with proteins is through its hydrophobic phenyl and naphthyl rings.

Supplier: Cayman Chemical Company

Simple, reproducible, and sensitive tool for measurement of glycerol in plasma and serum.

Supplier: Cayman Chemical Company

A kit for measuring ascorbate.

Supplier: Cayman Chemical Company

For the measurement of anti-ovalbumin of the IgG₁ isotype in mouse plasma and serum.

Supplier: Cayman Chemical Company

For direct quantification of cAMP from a variety of biological samples.

Supplier: Cayman Chemical Company

A competitive assay that can be used for quantification of 2-methoxyestradiol in plasma, urine, and other sample matrices.

Supplier: Cayman Chemical Company

96-Well assay for measurement of p53.

Supplier: Cayman Chemical Company

A fluorometric detection assay for hydrogen peroxide.

Supplier: Cayman Chemical Company

Enzyme immunometric assay for the measurement of mouse IL-6.

Supplier: Cayman Chemical Company

For the quantification of progesterone in plasma and other sample matrices.

Supplier: Cayman Chemical Company

A complete system for quantifying complex I inhibition.

Supplier: Cayman Chemical Company

A competitive assay for rapid screening for His-tagged proteins.

Supplier: Cayman Chemical Company

STING M284 variant Monoclonal Antibody, Clone: 8E7, Host: Mouse, Reactivity: Human, Isotype: IgG1, Immunogen: Synthetic peptide from the internal region of human STING protein containing the R284M mutation, Synony

Supplier: Cayman Chemical Company

An active, pure human recombinant enzyme.

Supplier: Cayman Chemical Company

RO8191, Purity >/=98%, CAS 691868-88-9, MF: C14H5F6N5O, MW: 373.2, Synonyms: Ro 494-8191, 8-(1,3,4-oxadiazol-2-yl)-2,4-bis(trifluoromethyl)-imidazo[1,2-a][1,8]naphthyridine, Formulation: A crystalline solid, Storage: -20C, Size: 10mg

Supplier: Cayman Chemical Company

CBL0137, Purity >/=95%, CAS 1197996-80-7, MF: C21H24N2O2, MW: 336.4, Synonyms: CBLC137, Curaxin 137, 1,1'-[9-[2-[(1-methylethyl)amino]ethyl]-9H-carbazole-3,6-diyl]bis-ethanone, Formulation: A crystalline solid, Storage: -20C, Size: 1mg

Supplier: Cayman Chemical Company

SC-514, Purity >/=98%, CAS 354812-17-2, MF: C9H8N2OS2, MW: 224.3, Synonyms: 4-amino-[2,3'-bithiophene]-5-carboxamide, selective and reversible inhibitor of IKB kinase 2, Formulation: A crystalline solid, Size: 10mg

Supplier: Cayman Chemical Company

Dimethyl biphenyl-4,4'-dicarboxylate, Purity >/=95%, CAS 792-74-5, MF: C16H14O4, MW: 270.3, Synonyms: Biphenyl dimethyl dicarboxylate, 4,4'-dimethyl ester [1,1'-biphenyl]-4,4'-dicarboxylic acid, Size: 25g

Supplier: Cayman Chemical Company

Interferon regulatory factor 3 (IRF3) is a member of the IRF family. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection, functioning as a molecular switch for antiviral activity. Double-stranded RNA generated during a viral infection leads to IRF3 activation by serine/threonine phosphorylation by TBK1 or IKBKE kinases, which induces a conformational change leading to its dimerization, nuclear localization, and association with CREBBP. The complex, known as DRAF1, activates transcription interferons alpha and beta, as well as other interferon-induced genes. These genes play a critical role in type 1 interferon (IFN)-dependent immune response. A recent study shows phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF recruits and specifies IRF3 phosphorylation and activation by the serine/threonine-protein kinase TBK1, thereby inducing the production of type-1 interferons.

Supplier: Cayman Chemical Company

DMXAA, Purity >/=98%, CAS 117570-53-3, Molecular Formula: C17H14O4, Formula Weight: 282.3, Synonyms: ASA 404, 5,6-Dimethylxanthenone-4-acetic Acid, NSC 640488, Vadimezan, Formulation: A crystalline solid, Storage: -20C, Size: 25mg

Supplier: Cayman Chemical Company

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates (STING), leading to activation of the type I interferon (IFN) pathway. In vitro, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS^-/-) mice do not produce type I IFNs following DNA transfection or DNA virus infection. Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses. In vivo, cGAS^-/- mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.

Supplier: Cayman Chemical Company

Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 (Item No. 22815) is found at a 13.7% frequency. Various mutations in STING either reduce or increase its activity. Gain-of-function mutations in STING, including R284M (Item No. 23594) and V155M, lead to constitutive activation and enhancement of the type I IFN response. The V155M mutation is associated with a systemic inflammatory condition, including pulmonary fibrosis and autoimmune factors. Mutations that reduce STING activity include K224R (Item No. 23593), which reduces ubiquitination of STING thereby disrupting its localization within the cell, and the double mutation G230A, R293Q (Item No. 23592), which reduces the IFN response. A T596A mutation present in the mouse strain Goldenticket leads to a complete loss of STING protein and lack of a type I IFN response to infection by Listeria.

Supplier: Cayman Chemical Company

A Certified Reference Material

Supplier: Cayman Chemical Company

A Certified Reference Material

Supplier: Cayman Chemical Company

A Certified Reference Material

Supplier: Cayman Chemical Company

A Certified Reference Material

Supplier: Cayman Chemical Company

A Certified Reference Material

Supplier: Cayman Chemical Company

A Certified Reference Material