172524 Results for: "CHEM-IMPEX INTERNATIONAL, INC"

Supplier: Immunoreagents

ImmunoReagents’ Alkaline Phosphatase (AP) antibody conjugates are used in ELISA, Immunohistochemistry (IHC) and Western blotting techniques. AP is a 140 kDa enzyme that changes color in the presence of PNPP or BCIP/NBT substrates. These conjugates have a linear reaction rate thus allowing the researcher to increase sensitivity by prolonging substrate incubation times.

Supplier: Thermo Fisher Scientific

Store samples securely at low temperatures, including vapor phase Liquid Nitrogen with Thermo Scientific™ Matrix™ 500 µl screw top tubes.

Supplier: Thermo Fisher Scientific

Securely store samples at low temperatures, including vapor phase liquid nitrogen with Thermo Scientific™ Matrix™ 1.0 ml Screw top tubes. 

Supplier: Cadence Science

Made of inert PEEK and designed for quick, leak-proof connections.

Supplier: Bioss

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).

Supplier: Peprotech

PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity ( Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037 ) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant Human PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues.

Supplier: Miele

The PLW 8505 laboratory glassware washer has a powerful circulation pump and is ideal for laboratory applications. Units have a stainless steel interior, glass door, include a steam condenser, liquid detergent and liquid acid neutralizer internal dispensing pumps. These glassware washers operate on 115V/60Hz. Performance/cycle, e.g., 39 narrow-neck/laboratory glassware with injectors.

Supplier: Prosci

Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 contains 2 CUB domain and 5 LDL-receptor class A domain. LRP12 has been shown to interact with GNB2L1, ZFYVE9 and ITGB1BP3. LRP12 is a receptor probably, which may be involved in the internalization of lipophilic molecules and/or signal transduction. In addition, LRP12 may act as a tumor suppressor.

Supplier: Bioss

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).

Supplier: Genetex

Epitope tags provide a method to localize gene products in a variety of cell types, study the topology of proteins and protein complexes, identify associated proteins, and characterize newly identified, low abundance or poorly immunogenic proteins when protein specific antibodies are not available. Tagging with xxxDDDDK may be done at the N-terminus, N-terminus preceded by a methionine residue, C-terminus, and in internal positions of the target protein. The small size of the epitope tag and its high hydrophilicity tend to decrease the possibility of interference with protein expression, proteolytic maturation, antigenicity and function. The enterokinase cleavage site allows it to be completely removed from the purified fusion proteins.

Supplier: Bioss

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Supplier: Prosci

The Adherens Junction Associated Protein 1 (AJAP1) plays a key role in cell adhesion and cell migration. It is a transmembrane protein found on the basolateral surface of epithelium and expressed by multiple types of epithelium. AJAP1 interacts with E-Cadherin and appears to promote the internalization of E-Cadherin upon growth factor stimulation. This facilitates the dissolution of adherens junctions with an increase in cell motility.

Supplier: Bioss

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).

Supplier: Bioss

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity).

Supplier: VWR International

DPTMDS deactivated fused silica retention gap/precolumn. General purpose deactivation for both apolar and polar solvents.

Supplier: VWR International

HMDS deactivated fused silica retention gap / precolumn. Deactivation mainly for apolar solvents.

Supplier: DWK Life Sciences (KIMBLE)

CryoELITE® cryogenic freestanding Vials have a Loctagon™ Vial Skirt that provides stability in the freestanding position and locks into the CryoELITE® Benchmate rack in order to provide easy open and close wiht one hand.

Supplier: Immunoreagents

ImmunoReagents’ Alkaline Phosphatase (AP) antibody conjugates are used in ELISA, Immunohistochemistry (IHC) and Western blotting techniques. AP is a 140 kDa enzyme that changes color in the presence of PNPP or BCIP/NBT substrates. These conjugates have a linear reaction rate thus allowing the researcher to increase sensitivity by prolonging substrate incubation times.

Supplier: DWK Life Sciences (KIMBLE)

DURAN® GL 45 Thread Adaptor for Bottle Top Vacuum Filtration (GL 45 External/GL 56 Internal), DURAN®

Supplier: LGC Standards

Organic Standard, HJ 827-2017 Carbamate Pesticides Internal Standards Mixture 177 25-100 µg/mL in Acetone

Supplier: Chemglass

Connecting adapters available in two different styles to best suit your needs.

Supplier: Genetex

Cytokeratin 7 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.

Supplier: Bioss

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).

Supplier: Bioss

Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).

Supplier: Immunoreagents

ImmunoReagents’ Alkaline Phosphatase (AP) antibody conjugates are used in ELISA, Immunohistochemistry (IHC) and Western blotting techniques. AP is a 140 kDa enzyme that changes color in the presence of PNPP or BCIP/NBT substrates. These conjugates have a linear reaction rate thus allowing the researcher to increase sensitivity by prolonging substrate incubation times.

Supplier: Prosci

CD36 (Cluster of Differentiation 36) is also known as platelet membrane glycoprotein IV (GPIV), fatty acid translocase (FAT), thrombospondin receptor, collagen receptor, and scavenger receptor class B, member 3 (SRB3), is a member of the class B scavenger receptor family of cell surface proteins. The human CD36 gene encodes a single chain 472 amino acid residue protein containing both an N- and a C-terminal cytoplasmic tail and an extracellular loop.CD36 is found on platelets, erythrocytes, monocytes, differentiated adipocytes, mammary epithelial cells, spleen cells and some skin microdermal endothelial cells. CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1, oxidized low-density lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, beta-amyloid fibrils (fA?), collagens I and IV, and Plasmodium falciparum infected erythrocytes. CD36 is required for the anti-angiogenic effects of thrombospondin1 In the corneal neovascularization assay. On binding a ligand the protein and ligand are internalized. This internalization is independent of macropinocytosis and occurs by an actin dependent mechanism requiring the activation Src-family kinases, JNK and Rho-family GTPases. CD36 ligands have also been shown to promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

Supplier: BDH

Stock multi-element ICP and ICP-MS blends can be found grouped for stability and ease of use as well as commonly used Certified Reference Materials (CRMs) recommended by many instrument manufactures

Supplier: Bioss

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.

Supplier: Bioss

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Interacts with MCC.

Supplier: Bioss

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.