129291 Results for: "CAFRAMO+LTD+CA&pageNo=10"

Supplier: Prosci

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes.

Supplier: Prosci

ZIP10 Antibody: ZIP10, also known as Slc39A10, is a widely expressed zinc transporter with nine transmembrane domains. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP10 mRNA was found to be significantly decreased in the intestines and kidneys of hypothyroid rats and increased in those of hyperthyroid rats, indicating that ZIP10 is positively regulated by thyroid hormones. ZIP10 mRNA was also found to be upregulated in invasive and metastatic breast cancer and cell lines, suggesting that ZIP10 could serve as a possible marker for the metastatic phenotype and possibly a target for novel treatment strategies. At least three isoforms of ZIP10 are known to exist.

Supplier: Prosci

GRB10 Antibody: GRB10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules and function in diverse cellular processes. GRB10 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of GRB10 inhibits tyrosine kinase activity and results in growth suppression. GRB10 can also interact with the L isoform of the proapoptotic protein Bim. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts.

Supplier: Peprotech

FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant Murine FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.

Supplier: Peprotech

IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Murine IL-1α is a 17.9 kDa protein containing 156 amino acid residues.

Supplier: Peprotech

Murine SF-20 is a bone marrow stroma-derived growth factor. SF20 is expressed in bone marrow, spleen stroma cells, resting mononuclear cells, resting CD8+ and CD19+ cells, and activated CD8+ T cells, and has been shown to bind to the surface of cells expressing the receptor TSA-1 (Thymic shared Ag-1). Among its biological activities, SF20 stimulates the proliferation of FDCP2 cells (a mouse factor-dependent hemopoietic cell line) and mouse lymphoid cells. Recombinant Murine SF-20 is a 15.8 kDa protein containing 143 amino acid residues.

Supplier: Peprotech

NNT-1/BCSF-3 is a neurotrophic factor with B-cell-stimulating capabilities. Expressed in the lymph nodes and spleen, NNT-1/BCSF-3 activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member β (LIFR-β) by binding and inducing the tyrosine phosphorylation of, these receptors. In vitro , it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss, and B-cell hyperplasia associated with increases in serum IgG and IgM. Recombinant Human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.

Supplier: Peprotech

FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated, heparin-binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland, liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant Human FGF-basic is a 16.4 kDa protein consisting of 146 amino acid residues.

Supplier: Peprotech

FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated, heparin-binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland, liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant Human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues.

Supplier: Peprotech

IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-γ-producing Th1 cells. Recombinant Human IL-12 p70 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).

Supplier: Peprotech

FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated, heparin-binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland, liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant Human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues.

Supplier: Therapak, LLC

All kits feature standardized components to maximize the ease of collecting and packing specimens for transport.

Supplier: Promega Corporation

Access RT-PCR System is designed for the reverse transcription and PCR amplification of a specific target RNA from total RNA or mRNA.

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 488 conjugates provide exceptional performance for a wide array of fluorescence-base applications at a lower cost than other 488-range dyes. DyLight® 488 shows greater photostability than traditional fluorescein-based dyes and has a greater range of pH insensitivity (pH 4-9). DyLight® 488 conjugates are available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 493nm / 518nm Emission Color = Green (Similar Dyes: Alexa Fluor 488, Cy2, FITC)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 488 conjugates provide exceptional performance for a wide array of fluorescence-base applications at a lower cost than other 488-range dyes. DyLight® 488 shows greater photostability than traditional fluorescein-based dyes and has a greater range of pH insensitivity (pH 4-9). DyLight® 488 conjugates are available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 493nm / 518nm Emission Color = Green (Similar Dyes: Alexa Fluor 488, Cy2, FITC)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 800 conjugates uses a near-IR fluorphore that is invisible to the naked eye but increases the staining options when using infrared imaging systems. DyLight® 800 has spectral properties that are very similar to other near-IR dyes, including Alexa Fluor 790 and IRDye 800, and has high solubility for maximal incorporation of the dye into the biomolecule of interest. Excitation/Emission = 777nm / 794nm Emission Color = Near IR (Similar Dyes: Alexa Fluor 790, IRDye 800)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 594 conjugates generate red fluorescence and shows wide excitation wavelength separation from green fluorophores for multi-color applications with reduced bleedthrough. The physical characteristics of DyLight® 594 are comparable to other 594 dyes. DyLight® 594 is available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 593nm / 618nm Emission Color = Red (Similar Dyes: Alexa Fluor 594, Texas Red)

Supplier: Bioss

Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Supplier: Genetex

Mouse monoclonal [61016.11] to Eotaxin 2

Supplier: Prosci

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This protein, a member of the claudin family, is an integral membrane protein and a component of tight junction strands.

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 550 conjugates provide vibrant orange-to-red fluorescence with better performance than other rhodamine derivatives, including Alexa Fluor 555, TRITC and Cy3 for fluorescent applications. DyLight® 550 conjugates have tight excitation/emission spectra that are ideal for multicolor applications. DyLight® 550 conjugated secondary antibodies are used in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 562nm / 576nm Emission Color = Orange to Red (Similar Dyes: Alexa Fluor 555, Cy3, TRITC)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 550 conjugates provide vibrant orange-to-red fluorescence with better performance than other rhodamine derivatives, including Alexa Fluor 555, TRITC and Cy3 for fluorescent applications. DyLight® 550 conjugates have tight excitation/emission spectra that are ideal for multicolor applications. DyLight® 550 conjugated secondary antibodies are used in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 562nm / 576nm Emission Color = Orange to Red (Similar Dyes: Alexa Fluor 555, Cy3, TRITC)

Supplier: Prosci

Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation.

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 650 conjugates provide vibrant far-red fluorescence with comparable or improved performance compared to other dyes for fluorescent applications. DyLight® 650 dye conjugates have tight excitation/emission spectra that are ideal for multi-color applications. DyLight® 650 conjugated secondary antibodies are available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 652nm / 672nm Emission Color = Far Red (Similar Dyes: Alexa Fluor 647, Cy5)

Supplier: Immunoreagents

ImmunoReagents’ FITC Conjugates are used in immunofluorescence microscopy, flow cytometry, FLISA (fluorescent ELISA) and high throughput screening assays. Fluorescein is typically excited by the 488 nm line of an argon laser, and emission is collected at 518 nm. FITC antibody conjugates are yellow-orange in color but emit a yellow-green color upon Em 518 nm. FITC antibody conjugates are sensitive to light. The typical FITC to antibody ratio (F/P) is >4.0 Excitation/Emission = 494nm / 518nm Emission Color = Green (Similar Dyes: Alexa Fluor 488, Cy2, DyLight ® 488)

Supplier: Prosci

Dynamin is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis. Cyclin dependent protein kinase 5 phosphorylates dynamin at Ser774 and Ser778 that are the phosphorylation sites on dynamin phosphorylated in vivo. Phosphorylation of these sites on dynamin is thought to play a key role in synaptic vesicle trafficking.

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 488 conjugates provide exceptional performance for a wide array of fluorescence-base applications at a lower cost than other 488-range dyes. DyLight® 488 shows greater photostability than traditional fluorescein-based dyes and has a greater range of pH insensitivity (pH 4-9). DyLight® 488 conjugates are available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 493nm / 518nm Emission Color = Green (Similar Dyes: Alexa Fluor 488, Cy2, FITC)

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 488 conjugates provide exceptional performance for a wide array of fluorescence-base applications at a lower cost than other 488-range dyes. DyLight® 488 shows greater photostability than traditional fluorescein-based dyes and has a greater range of pH insensitivity (pH 4-9). DyLight® 488 conjugates are available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 493nm / 518nm Emission Color = Green (Similar Dyes: Alexa Fluor 488, Cy2, FITC)

Supplier: Prosci

Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.

Supplier: Immunoreagents

The ImmunoReagents' DyLight® 488 conjugates provide exceptional performance for a wide array of fluorescence-base applications at a lower cost than other 488-range dyes. DyLight® 488 shows greater photostability than traditional fluorescein-based dyes and has a greater range of pH insensitivity (pH 4-9). DyLight® 488 conjugates are available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 493nm / 518nm Emission Color = Green (Similar Dyes: Alexa Fluor 488, Cy2, FITC)