36196 Results for: "Bis(2-ethylhexyl)phosphate&pageNo=12"

Supplier: Rockland Immunochemical

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.

Supplier: Rockland Immunochemical

PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease.

Supplier: FUJIFILM IRVINE SCIENTIFIC INC.

BalanCD CHO Perfusion is a chemically defined medium that is optimized for the growth and production of suspension CHO cell cultures in continuous, steady-state, and N-1 perfusion cultures. As a high performing medium, it can achieve key perfusion metrics including cell-specific productivity, volumetric productivity, and cell-specific perfusion rate (CSPR). BalanCD CHO Perfusion medium meets the requirements of large-scale industrial cell cultures and is intended for long-term, continuous culturing of CHO cells. Support the growth and productivity of CHO cells in perfusion culture systems with BalanCD CHO Perfusion, a chemically defined, complete, and ready-to-use medium. Optimize and achieve key perfusion metrics including cell-specific productivity, volumetric productivity, and cell-specific perfusion rate (CSPR) for continuous, steady-state, and N-1 perfusion cultures.

Supplier: SenseAnywhere

The SenseAnywhere AiroSensor 20-20-41 with Magnetic Door Contact Set is the ultimate solution to your refrigeration and freezer challenges. We all know the frustration of discovering that your fridge or freezer has failed due to an open door. With this efficient duo, you can say goodbye to this common problem.

Supplier: Invitrogen

GEL TRIS-GLYCIN MINI PROTIN 412% 1.0MM

Supplier: Cell Systems

Our primary human cells offer unmatched consistency and a more biologically relevant tool than other cell types. Our cells are antibody-free and come from a deep inventory to help researchers with reproducibility and improved human insights.

Supplier: TRESTON IAC LLC

Dimension 4 Workstations are the most versatile and useful workstation modules available.

Supplier: Thermo Fisher Scientific

Stackable orbital shakers provide an ideal solution for both sensitive cultures and traditional 'hard shake' applications in incubated and refrigerated configurations.

Supplier: Rockland Immunochemical

SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.

Supplier: Sartorius

These MCE series essential user interface balance was a large, high-contrast touch display with factory-installed essential weighing applications for easy operation.

Supplier: Oxford Nanopore Technologies

Rapid Sequencing Kits offer a simple and rapid library preparation method for genomic DNA sequencing on MinION™ devices.

Supplier: Genetex

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq]

Supplier: Rockland Immunochemical

Human fibronectin has a molecular weight of 450,000 daltons when purified in an intact form from plasma. Fibronectin is a glycoprotein synthesized in the liver for the circulating blood plasma form, and is synthesized by many mesenchymal cells, for the extracellular matrix form. It is composed of two similar, but not identical protein chains, which are linked by two disulfide linkages at the C-terminal end of the chains. The chains are composed of domains which have specific secondary structures linked together by regions which are especially susceptible to proteolytic action. For this reason, detection by immunoblot (western) may show considerable variability in the observed apparent molecular weights, which is predicated on the source of the fibronectin, and to what degree proteolysis has occurred. Bands approximately 225 kDa should be observed after SDS-PAGE when reducing and denaturing conditions are used.

Supplier: Cell Systems

Our primary human cells offer unmatched consistency and a more biologically relevant tool than other cell types. Our cells are antibody-free and come from a deep inventory to help researchers with reproducibility and improved human insights.

Supplier: Invitrogen

GEL TRIS-GLYCINE 412% 1MM WEDGEWEL PK10

Supplier: GRANT USA INC.

General Purpose Water Baths with stable temperature control, simple interface and fast heat-up. Choose from four models each with base tray and lid included as standard.
The JB Nova general purpose unstirred water bath range benefits from key features such as the newly incorporated Set and Forget™ technology with advanced dry start and run dry protection. These are in addition to the standard features including an element free tank, user calibration, front panel lock and drain tap on sizes 12L and above

Supplier: Germaine Laboratories

COVID-19/Flu A and B antigen combo rapid test cassette (Swab) is CLIA waived under FDA EUA, and provides faster diagnosis for improved patient care and cost-effectiveness. Results are available in 15 minutes.

Supplier: Eppendorf

Eppendorf epT.I.P.S.® 384 Sets, featuring 'Eppendorf Quality' micropipette tips, are optimized for 384-well plate precision. They combine ergonomic box design with high-throughput efficiency, ideal for advanced lab applications requiring accuracy. The epT.I.P.S.® 384 pipette tips build a system together with the Research® plus and Xplorer® plus 16- and 24-channel pipettes, as well as 20 and 100 µl Move It® adjustable tip spacing pipettes for the utmost safety and reliability.

Supplier: Eppendorf

Eppendorf epT.I.P.S.® 384 Reloads provide high-precision micropipette tips in 'Eppendorf Quality' and 'PCR clean' grades, tailored for 384-well plate applications, ensuring accuracy, reduced waste, and compatibility in high-throughput labs. The epT.I.P.S.® 384 pipette tips build a system together with the Research® plus and Xplorer® plus 16- and 24-channel pipettes, as well as 20 and 100 µl Move It® adjustable tip spacing pipettes for the utmost safety and reliability.

Supplier: Thermo Fisher Scientific

TSX Universal series ULT freezers are the pinnacle of reliability, sustainability, and innovation incorporating insights from over 80 years of experience to enhance every aspect of the system. Updates to the variable speed compressors has made the TSX Universal adaptable across all workflows. Available in four capacities, they are ENERGY STAR® certified with a 33% energy efficiency improvement, ACT labeled and produced in a Zero-Waste to Landfill certified facility.

Supplier: Binder

The MKF series of dynamic climate chambers has been specially developed as precision heating and cooling chambers for industrial material testing and environment simulation applications. The units are ideal for rapid temperature changes with humidity control and have a higher capacity which exceeds the capability of normal testing chambers. The stainless-steel inner chamber has door heating, a heated viewing window with LED interior lighting and programmable condensation protection for the test materials.

Supplier: ABCAM INC CA

ab185907 is designed to carry out bisulfite conversion, followed by a "post-bisulfite" library preparation process for Illumina® platform-based bisulfite sequencing, all in one kit.

Supplier: Bioss

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Supplier: Bioss

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Supplier: Genetex

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq]

Supplier: Leica Microsystems

The Leica DM750 microscope is an advanced educational tool, with a wireless camera, Koehler illumination, and high-quality optics for clear observations. Enhance classroom experience with advanced imaging and comprehensive exploration.

Supplier: Sedia Biosciences

Sedia’s Asanté™ Dried Blood Specimen Collection Strips (Asanté™ Strips) are intended for the collection, transport, storage, testing, and archiving of blood specimens, including finger-stick blood, venous blood, serum, or plasma.

Supplier: Bioss

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

Supplier: Thermo Fisher Scientific

Designed to achieve your next breakthrough. Better solutions for optimal cell growth, VIOS CO₂ incubators provide the ideal in-vitro environment.

Supplier: Rockland Immunochemical

Human fibronectin has a molecular weight of 450,000 daltons when purified in an intact form from plasma. Fibronectin is a glycoprotein synthesized in the liver for the circulating blood plasma form, and is synthesized by many mesenchymal cells, for the extracellular matrix form. It is composed of two similar, but not identical protein chains, which are linked by two disulfide linkages at the C-terminal end of the chains. The chains are composed of domains which have specific secondary structures linked together by regions which are especially susceptible to proteolytic action. For this reason, detection by immunoblot (western) may show considerable variability in the observed apparent molecular weights, which is predicated on the source of the fibronectin, and to what degree proteolysis has occurred. Bands approximately 225 kDa should be observed after SDS-PAGE when reducing and denaturing conditions are used.