9685 Results for: "Biotium"

Supplier: Biotium

GelRed™ and GelGreen™ are a new generation of fluorescent nucleic acid gel stains designed to replace the highly toxic ethidium bromide (EtBr)

Supplier: Biotium

MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: MUC18/1130, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: CF594, Immunogen: Recombinant human MUC18 protein, Application: IF, Immunohistology (formalin), Flow, Size: 100uL

Supplier: Biotium

MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: MUC18/1130, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: CF568, Immunogen: Recombinant human MUC18 protein, Application: IF, Immunohistology (formalin), Flow, Size: 100uL

Supplier: Biotium

CD98 exits as a heterodimer containing a disulphide-linked glycosylated heavy chain and a non-glycosylated light chain. It is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through disulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.

Supplier: Biotium

MAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45 kDa, containing 8 kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.

Supplier: Biotium

MUC18 / Mucin 18 / CD146, Monoclonal antibody, Clone: OJ79c, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: biotin, Immunogen: Recombinant human MUC18 protein, Application: IF, Immunohistology (formalin), Flow cytometry, Size: 500uL

Supplier: Biotium

HER-2 / CD340, Monoclonal antibody, Clone: HRB2/282, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Recombinant intracellular domain of human HER-2 protein, Synonyms: p185, CD340, Verb b2, Size: 500uL

Supplier: Biotium

This MAb is specific to c-erbB-2/HER-2 and shows minimal cross-reaction with other members of the family. C-erbB-2/HER-2 is a member of the EGFR family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

Supplier: Biotium

HCG-intacT, Monoclonal antibody, Clone: HCGab/52, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Purified hCG protein, Application: Immunohistology (formalin), Size: 100uL

Supplier: Biotium

c-Myc Monoclonal antibody, Clone: MYC275, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: BSA-free, Immunogen: Recombinant human c-myc protein, Application: IF, Immunohistology (formalin), FC, Size: 50 uL

Supplier: Biotium

TOX3, Monoclonal antibody, Clone: TOX3/1124, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein, Synonyms: TOX3, Size: 500uL

Supplier: Biotium

CD50 Monoclonal antibody, Clone: 186-2G9, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF568, Immunogen: Stimulated human leukocytes, Synonyms: ICAMR, Intercellular adhesion molecule 3 (ICAM3), Application: IF, Immunohistology, Size: 100uL

Supplier: Biotium

Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural protein, which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development, and is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2. The antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature, which may distinguish benign breast lesions and carcinoma in situ from invasive tumors.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

CD45 / LCA Monoclonal antibody, Clone: 135-4C5, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: CF405S, Immunogen: Stimulated human leukocytes, Synonyms: B220, CD45R, Application: IF, IHC, FC, Size: 100uL

Supplier: Biotium

Transgelin / SM22-alphA, Monoclonal antibody, Clone: TAGLN/247, Host: Mouse, Species reactivity: Pig, Cow, Human, Rabbit, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recombinant full-length human transgelin (TAGLN) protein, Application: IF, Size: 500uL

Supplier: Biotium

Transgelin / SM22-alphA, Monoclonal antibody, Clone: TAGLN/247, Host: Mouse, Species reactivity: Pig, Cow, Human, Rabbit, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Recombinant full-length human transgelin (TAGLN) protein, Application: IF, Size: 100uL

Supplier: Biotium

This MAb recognizes the HLA-B27 cell surface antigen on human cells. It may be used to HLA type human lymphocytes. Approximately 60% of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in human lymphocytes. Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind pep- tides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B encodes a membrane anchored heavy chain, which hetero-dimerizes with a light chain (Beta-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B alleles. The HLA-B27 allele appears with increased frequency in uveitis patients.

Supplier: Biotium

This antibody recognizes a protein of 185 kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Supplier: Biotium

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Supplier: Biotium

Tyrosinase, Monoclonal antibody, Clone: T311, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF568, Immunogen: Recombinant tyrosinase protein (T311); Recombinant human TYR protein, Synonyms: CMM8, LB24-AB, Application: IF, Size: 100uL

Supplier: Biotium

Neurofilament (H+L), Monoclonal antibody, Clone: NF421 + NFL736, Host: Mouse, Species reactivity: Mouse, Pig, Rat, Human, Chicken, Isotype: IgG's, Conjugate: CF640R, Immunogen: Recombinant human neurofilament heavy sub-unit (RT-97) & light sub-unit (NR-4), Size: 100uL

Supplier: Biotium

This MAb recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells. This MAb produces a homogeneous staining pattern in the nucleus of normal and malignant cells. Deoxyribonucleic acid (DNA) is a nucleic acid that stores long-term information regarding the development and function of all known living organisms. DNA consists of two long nucleotide polymers, which are composed of four bases, namely adenine, thymine, guanine and cytosine, all of which are flanked by a phosphate-deoxyribose backbone. Normally, DNA exists as a double-stranded (ds) molecule that forms in the shape of a double helix, allowing the bases and the backbone of the two strands to interact, thus forming a polynucleotide. When the double helix is unwound (either by enzymes or heat), DNA exists as a single-stranded (ss) molecule that is less stable than the double helix, but is necessary for protein access to DNA bases. Double stranded DNA markers are useful tools in biology research and aid in the study of DNA behavior and characteristics.

Supplier: Biotium

This monoclonal antibody is part of a new panel of reagents, which recognizes subcellular organelles or compartments of human cells. These markers may be useful in identification of these organelles in cells, tissues, and biochemical preparations. This MAb recognizes the double stranded DNA in human cells. It can be used to stain the nuclei in cell or tissue preparations and can be used as a nuclear marker in human cells. This MAb produces a homogeneous staining pattern in the nucleus of normal and malignant cells.,Double Stranded deoxyribonucleic acid (ds DNA) is the genetic material of all cells and many viruses and is a polymer of nucleotides. The monomer consists of phosphorylated 2-deoxyribose N-glycosidically linked to one of four bases, adenine, cytosine, guanine or thymine. These are linked together by 3',5'-phosphodiester bridges. In the Watson-Crick double-helix model, two complementary strands are wound in a right-handed helix and held together by hydrogen bonds between complementary base pairs.

Supplier: Biotium

UACA / Nucling, Monoclonal antibody, Clone: UACA/1222, Host: Mouse, Species reactivity: Mouse, Human, Isotype: IgG's, Conjugate: CF488A, Immunogen: Recombinant human UACA protein, Synonyms: Nuclear membrane binding protein, Application: IF, Western, Flow, Size: 100uL

Supplier: Biotium

CD45RB Monoclonal antibody, Clone: BRA-11G, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Non-T, non-B CALLA positive ALL cell line REH, Synonyms: B220, CD45R, Application: IF, IHC, FC, Size: 500 uL

Supplier: Biotium

IgA Immunoglobulin, Monoclonal antibody, Clone: IA761, Host: Mouse, Species reactivity: Human, Isotype: IgG1, Conjugate: biotin, Immunogen: Purified human alpha heavy chain, Synonyms: A2m Marker; Ig alpha 1 Chain C Region, Application: IF, IHC, Size: 100uL

Supplier: Biotium

This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Supplier: Biotium

This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.

Supplier: Biotium

This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy. It strongly stains nuclei of epithelial cells in breast carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

This MAb is specific to ER alpha and shows minimal cross-reaction with other members of the family. Epitope of this MAb is mapped between aa120-170. ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.