2270 Results for: "BioVendor"

Supplier: BioVendor

Albumin is mostly a simple hydrophilic protein present in cells and body fluids.

Supplier: BioVendor

Listeriolysin O (aka LLO) is a hemolysin produced by Listeria monocytogenes bacteria, the pathogen responsible for causing listeriosis. The toxin may be regarded as a virulence factor, since it is crucial for the virulence of L. monocytogenes. LLO is a single polypeptide protein encoded by the hlyA gene and composed of 529 residues. LLO is a thiol-activated cholesterol-dependent pore forming toxin protein; therefore, it is activated by reducing agents and inhibited by oxidizing agents. Still, LLO differs from other thiol-activated toxins, as its cytolytic activity is maximized at a pH of 5.5. Inside the acidic phagosomes (average pH ~ 5.9) of cells that have phagocytosed L. monocytogenes, LLO is selectively activated by maximizing activity at a pH of 5.5. Following the phagosome lysis by LLO, the bacterium breaks out into the cytosol, where it is able to grow intracellularly, and the toxin has reduced activity in the more basic cytosol. Thus, LLO permits L. monocytogenes to break out from the phagosomes into the cytosol without harming the plasma membrane of the infected cell, which allows the bacteria to live intracellularly, where they are sheltered from extracellular immune system factors such as the complement system and antibodies.

Supplier: BioVendor

In serum, FLC kappa exists predominantly as a monomer with a molecular weight of 22.5 kDa and FLC lambda as a dimer with a molecular weight of 45 kDa.

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Thermostable dUTPase (pyrococcus fruriosus) maximizes the efficiency of high-fidelity PCR (using proofreading DNA polymerases)

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96 wells (1 kit) - ELISA is a competitive enzyme immunoassay for the quantitative measurement of AFABP4.

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IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood.

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The ENDONEXT™ EndoZyme® II assay is the enhanced second generation of EndoZyme®, based on recombinant Factor C (rFC), the synthetic analogue to the native endotoxin-specific principal receptor in the limulus amebocyte lysate (LAL) cascade.

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Total 190 AA. MW: 21.8 kDa (calculated). UniProtKB acc.no. P09429 (Gly2-Ser181). N-terminal histag (10 extra AA). Protein identity confirmed by LC-MS/MS.

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Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

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IL-1α is predominantly a cell-associated, non-secreted proinflammatory cytokine.

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IL-22/TIF is a new cytokine originally identified as a gene induced by IL-9 in murine T lymphocytes.

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sIL-2R is a marker for T cell activation.

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96 wells (1 kit) - ELISA is a sandwich enzyme immunoassay for the quantitative measurement of insulin.

Supplier: BioVendor

Nesfatin-1 was first described in 2006 as a neurohormone derived from the protein NEFA/nucleobindin2 (NUCB2). It is a polypeptide consisting of 82 amino acids, with high level of homology in human, mouse and rat. Nesfatin-1 has been localized in the brain, particulary in the nuclei of the hypothalamus, in the adipose tissue and the gastrointestinal tract, but also in serum and cerebrospinal fluid. Nesfatin-1 was identified as a satiety molecule affecting fat metabolism. Intracerebroventricular administration of nesfatin-1 induces decreases in food intake and body weight and increases in sympathetic nerve activity and mean arterial pressure. Effect of Nesfatin-1 is leptin – independent, it is probably mediated by melanocortin system. Several studies are currently focused on the possibility of using Nesfatin-1 in the treatment of obesity, even in individuals with leptin resistence. Due to the presence in serum Nesfatin-1 could also serve as a clinical marker in the diagnosis of many diseases.

Supplier: BioVendor

Total 444 AA. MW: 49,03 kDa (calculated). UniProtKB acc.no. Q99541. N-Terminal His-tag, 8 extra AA

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Native protein isolated from human urine, 590 AA, 64265 kDa (calculated without glycosylation). Protein identity confirmed by LC-MS/MS.

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Vascular adhesion protein-1 (VAP-1) is one of the endothelial cell adhesion molecules that mediates lymphocyte binding to the endothelium under shear conditions.

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Progranulin can restrain TNF mediated pro-inflammatory processes.

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Specifications of EndoGrade® ovalbumin:
Source: chicken egg white
Synonyms: Plakalbumin, Allergen Gal d 2, Gal d II
Preparation: Prepared from egg white by ion exchange, crystallization and subjected to pH 4.6 during manufacturing
Purity (SDS-Page): >98%
Contains no salts

Supplier: BioVendor

Cystatin C is a non-glycosilated basic single-chain protein consisting of 120 amino acids with a molecular weight of 13.36 kDa and is characterized by two disulfide bonds in the carboxy-terminal region

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CTRP1 (Complement C1q tumor necrosis factor-related protein 1) is a member of the CTRP superfamily and is localized to human chromosome 17.

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Estradiol is one of the main components of naturally occurring estrogens and is the major estrogen secreted during the menstrual cycle.

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Chemokines (chemoattractant cytokines) represent a superfamily of small secreted proteins that function as intercellular messengers.

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The determination of plasma C-Peptide allows an assessment of the endogenous insulin production

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Monocyte chemotactic protein-1 (MCP-1) is a member of the C-C family of chemokines.

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L-selectin could provide more detailed insights into the pathological modifications during various diseases.

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96 wells (1 kit) - ELISA is a competitive enzyme immunoassay for the quantitative measurement of Omentin-1.

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The obestatin concerning study for energy homeostasis and body weight regulation could be expected to have a large development in the future.

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96 wells (1 kit) - ELISA is a sandwich enzyme immunoassay for the quantitative measurement of pNF-H.

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A soluble form of PECAM-1 is smaller than cell-associated PECAM-1, and contains the cytoplasmic tail.