8143 Results for: "Bachem Americas"

Supplier: Bachem Americas

The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Aβ40 and 42 can be N-terminally truncated by action of cathepsin B. The cyclization of Glu³ is catalyzed by glutaminyl cyclase. Hence, inhibition of these enzymes could be a therapeutic approach to AD.

Supplier: Bachem Americas

Effective catalyst for conjugate addition reactions of aldehydes to β-substituted nitroolefins.

Supplier: Bachem Americas

H-Asp(OtBu)-2-chlorotrityl resin (200-400 mesh) (Low Substitution) 1g, Storage Condition: -20 +/- 5 degree C, Substitution < 0. 60 mmol/g.

Supplier: Bachem Americas

Fmoc-[D2]Gly-OH 1g, Molecular Formula: C17H13D2NO4, Storage Condition: Room Temperature, Cas number: 284665-11-8.

Supplier: Bachem Americas

Substitution 0.50-0.90 mmol/g Storage Conditions -20 +/- 5 Deg C 5g

Supplier: Bachem Americas

Nω-Methylation is a widespread post-translational modification of Arg-containing proteins. Arg(Me) can be conveniently introduced during the Fmoc-SPPS of model peptides using this derivative.

Supplier: Bachem Americas

Boc-Oic-OH, (2S, 3aS, 7aS)-1-Boc-octahydro-1H-indole-2-carboxylic acid 1g, Cas number 109523-13-9, Storage Condition: -20 +/- 5 degree C

Supplier: Bachem Americas

Han et al. used Fmoc-(D₁₀)-Leu-OH for obtaining labeled Ac-WL₅, a hexapeptide forming β-sheets in membranes. The aggregation of the tagged peptide was followed by neutron scattering.

Supplier: Bachem Americas

These dipeptide building blocks containing Ser- or Thr-derived oxazolidines (pseudoprolines) proved to be versatile tools for overcoming some intrinsic problems in the field of peptide chemistry. The presence of pseudoprolines within a peptide sequence results in the disruption of β-sheet structures considered as a source of intermolecular aggregation during chain elongation, thus increasing solvation and coupling kinetics in peptide assembly. Therefore, use of pseudoprolines offer new possibilities for accessing large peptides by convergent strategies and chemoselective ligation techniques. Moreover, incorporation of a pseudoproline unit facilitates cyclization of peptides.

Supplier: Bachem Americas

These dipeptide building blocks containing Ser- or Thr-derived oxazolidines (pseudoprolines) proved to be versatile tools for overcoming some intrinsic problems in the field of peptide chemistry. The presence of pseudoprolines within a peptide sequence results in the disruption of β-sheet structures considered as a source of intermolecular aggregation during chain elongation, thus increasing solvation and coupling kinetics in peptide assembly. Therefore, use of pseudoprolines offer new possibilities for accessing large peptides by convergent strategies and chemoselective ligation techniques. Moreover, incorporation of a pseudoproline unit facilitates cyclization of peptides.

Supplier: Bachem Americas

An alternative to Mob in the regioselective formation of disulfide bonds.

Supplier: Bachem Americas

Bachem also offers derivatives of phosphoserine and sulfoserine.

Supplier: Bachem Americas

Hepcidin-20, a degradation product of hepcidin-25 found in plasma and urine, shows an increased antimicrobial activity compared to the full-length peptide, but it is not involved in iron metabolism.

Supplier: Bachem Americas

PG 97-269 is a selective high affinity VPAC1 receptor antagonist with negligible affinity for the PACAP type I receptor. The Ki values were 15 +/- 5 nM for the rat and 2 +/- 1 nM for the human VPAC1 receptors. PG 97-269 may be useful for the evaluation of the physiological role of VIP in rat and human tissues.

Supplier: Bachem Americas

H-Tyr(tBu)-2-chlorotrityl resin (200-400 mesh) (Low Substitution) 1g, Substitution 0. 20-0. 49 mmol/g, Storage Condition: -20 +/- 5 degree C.

Supplier: Bachem Americas

Please see also α-MSH (corresponds to acetyl-ACTH (1-13) amide, H-1075), α-MSH (free acid) (acetyl-ACTH (1-13), H-1070), and (Des-acetyl)-α-MSH (H-4390). Wied: Pituitary Adrenal System Hormones and Behaviour. Symposium on Developments in Endocrinology (1976) / Anon.: ACTH and Related Peptides: Structure, Regulation, and Action. Ann. N.Y. Acad. Sci. 297, 1 (1977) / A.V.Schally: Aspects of Hypothalamic Regulation of the Pituitary Gland. Science 202, 18 (1978) / R.Schwyzer: Studies on Polypeptide Receptors. A Critical View on the Mechanism of ACTH Action. Bull. Schweiz. Acad. Med. Wiss. 34, 263 (1978).

Supplier: Bachem Americas

Amyloid beta Protein (1-40) (HFIP-treated), Synonym: Abeta 40 (HFIP-treated), Molecular Formula: C194H295N53O58S, CAS: [131438-79-4] net, Obtained by dissolving Amyloid beta Protein (1-40) in HFIP, aliquoting, and removing the solvent, For Alzheimers Disease

Supplier: Bachem Americas

The dipeptide Leu-Gly inhibits the ubiquitin-mediated proteolysis.

Supplier: Bachem Americas

Sequence: H-Gly-βNA · HCl

Supplier: Bachem Americas

Sequence: H-His-βNA

Supplier: Bachem Americas

Ca²⁺ calmodulin-dependent protein kinase II and Ca²⁺ phospholipid-dependent protein kinase (PKC) were selectively assayed using syntide 2 as substrate. The sequence of syntide 2 is homologous to phosphorylation site 2 in glycogen synthase.

Supplier: Bachem Americas

This fragment is able to compete with the intact NPY for essentially all binding sites in rat brain. However, it is less potent than the native peptide in its NPY-receptor binding affinity.

Supplier: Bachem Americas

Sequence: Fmoc-Lys(Boc)(Me)-OH

Supplier: Bachem Americas

The galanin receptor agonist galnon binds to the same brain-surface proteins, or receptors, that galanin does and prevents seizures. This drug mimicking a natural substance in the brain may represent a prototype for a new class of epilepsy drugs.

Supplier: Bachem Americas

This box contains the 20 standard Fmoc-amino acid L-derivatives (5 g each).

Supplier: Bachem Americas

Sequence: Z-Lys(Boc)-OH

Supplier: Bachem Americas

Sequence: Z-Orn(Boc)-OH

Supplier: Bachem Americas

Sequence: Z-Gly-Pro-Arg-AMC · HCl

Supplier: Bachem Americas

Isoacyl dipeptides have been developed as building blocks for preventing aggregation of the growing peptide chains during Fmoc-SPPS. As the isopeptide structure is not affected by the final acidolytic cleavage the solubility of the crude product is improved facilitating the subsequent purification. The depsipeptide will rearrange yielding the desired product in slightly basic solution.

Supplier: Bachem Americas

Sequence: H-Arg-AMC