"Bachem Americas"
O-tert-Butyl-L-serine methyl ester hydrochloride
Supplier: Bachem Americas
Sequence: H-Ser(tBu)-OMe · HCl
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ent-beta-Amyloid (1-42)
Supplier: Bachem Americas
All-D Aβ (1-42) exhibits similar properites as the all-L Aβ. The peptide forms ion channels in lipid bilayers.
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H-Glu-Ala-Leu-Phe-Gln-pNA Trifluoroacetate
Supplier: Bachem Americas
The substrate EALFQ-pNA representing the 2C/3A cleavage site of human rhinovirus-14 (HRV-14) polyprotein was hydrolyzed by human rhinovirus-14 3C protease, which represents an attractive target for antiviral drug development. It exhibited a kcat/Km value of 840 M⁻¹s⁻¹.
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H-Pro-Phe-OH
Supplier: Bachem Americas
See also E-2410, Suc-Pro-OH, the product familiy 'Antihypertensive Peptides' and the subfamily 'Bradykinin-Potentiating Peptides (BPP)'.
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H-D-Pro-Pro-Glu-NH2 Trifluoroacetate
Supplier: Bachem Americas
In the presence of as little as 1 mol% pPE-amide, a broad range of aldehydes and nitroolefins react readily with each other. The resulting γ-nitroaldehydes were obtained in excellent yields and stereoselectivities at room temperature.
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Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)
Supplier: Bachem Americas
TSST-1 is a "superantigen" which binds to MHC class II molecules and induces stimulation of T cells. This TSST-1 fragment has an active site of the TSST-1 holotoxin which binds to MHC class II molecules and is able to xenostimulate T cells in an MHC unrestricted manner. Therefore this peptide could be of great value in studying the immunobiology of MHC class II molecules.
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LHRH (1-5) (free acid) Trifluoroacetate
Supplier: Bachem Americas
LHRH is also called Gonadotropin-Releasing Hormone (GnRH) or Luteinizing Hormone-Releasing Factor (LRF).
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Human (Des-octanoyl)-Ghrelin Trifluoroacetate
Supplier: Bachem Americas
Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.
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