1597 Results for: "BIOGEMS INTERNATIONAL INC."

Supplier: BIOGEMS INTERNATIONAL INC.

The APA5 monoclonal antibody specifically binds to the mouse CD140a molecule, otherwise known as the Platelet-Derived Growth Factor (PDGF) Receptor alpha chain. CD140a is a receptor tyrosine kinase expressed on embryonic tissues and adult mesenchymal-derived cells. It binds to PDGF A and B chains and is reported to be involved with wound healing and exhibits chemo-attractant properties. The APA5 antibody blocks the binding of PDGF-AA to the PDGF receptor.

Supplier: BIOGEMS INTERNATIONAL INC.

The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1). VLA-2 is expressed on NK-T cells, epithelial cells, platelets, and CD+4 T lymphocytes. It is the receptor for laminin and collagen and is upregulated in response to mitogens. The Hma2 antibody is reported to partially block the interaction with collagen in T cells, but not NK cells.

Supplier: BIOGEMS INTERNATIONAL INC.

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.

Supplier: BIOGEMS INTERNATIONAL INC.

The 2E7 monoclonal antibody specifically reacts with mouse CD103, a type I transmembrane glycoprotein in the integrin family that bind to E-cadherin. CD103 is expressed on intraepithelial lymphocyte T cells, peripheral regulatory T cells, lamina propria T cells, and a subset of dendritic cells. It is reported to be involved in T cell homing and immune system regulation.

Supplier: BIOGEMS INTERNATIONAL INC.

The PK136 monoclonal antibody is specific for the mouse NK1.1, a receptor from the killer cell lectin-like receptor (KLR) family. Nk1.1 is an antigen encoded by the Klrb1c/NKR-P1C gene expressed by the natural killer cells of some selected strains of mice (C57BL, FVB/N, NZB) and encoded by the Klrb1b/NKR-P1B gene expressed on Swiss NIH and SJL mice. Pk136 binds to an epitope common to NKR-P1B and NKR-P1C.The Klrb1 is a family of type II transmembrane C-type lectin receptors. Klrb1c activates the NK-cell cytotoxicity, while Klrb1b inhibits it. PK136 is useful in defining the NK cells and the rare population of NK-T lymphocytes and specific cultured monocytes.

Supplier: BIOGEMS INTERNATIONAL INC.

The DATK32 monoclonal antibody specifically reacts with an epitoPEof the Mouseα4β7 integrin (LPAM-1). The two subunits of the LPAM-1 heterodimer are the 154 kDa α4 and the 130 kDa β7. Most mature lymphocytes, a subset of bone marrow cells, and some of the thymic cells express the α4β7 integrin heterodimer. α4β7 enhances the transendothelial migration of lymphocytes, and interacts with several ligands (fibronectin, CD106, and MAdCAM-1). The interaction of DATK32 with the α4β7 induces the α4β7-dependent lymphocyte aggregation and inhibits LPAM-1-dediated cell adhesion.

Supplier: BIOGEMS INTERNATIONAL INC.

The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

Supplier: BIOGEMS INTERNATIONAL INC.

The BM8.1 monoclonal antibody specifically binds to the Mouse125 kDa F4/80 antigen, expressed by most mature macrophages. F4/80 is a transmembrane protein used as a marker of macrophages, although it is also expressed on Kupffer and Langerhans cells. The expression of F4/80 antigen is upregulated on bone marrow cells stimulated in vitro with the macrophage colony stimulating factor. The F4/80 antigen is a requirement for the induction of CD8 T cells-mediated peripheral tolerance.

Supplier: BIOGEMS INTERNATIONAL INC.

The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.

Supplier: BIOGEMS INTERNATIONAL INC.

The BM8.1 monoclonal antibody specifically binds to the Mouse125 kDa F4/80 antigen, expressed by most mature macrophages. F4/80 is a transmembrane protein used as a marker of macrophages, although it is also expressed on Kupffer and Langerhans cells. The expression of F4/80 antigen is upregulated on bone marrow cells stimulated in vitro with the macrophage colony stimulating factor. The F4/80 antigen is a requirement for the induction of CD8 T cells-mediated peripheral tolerance.

Supplier: BIOGEMS INTERNATIONAL INC.

The BM8.1 monoclonal antibody specifically binds to the Mouse125 kDa F4/80 antigen, expressed by most mature macrophages. F4/80 is a transmembrane protein used as a marker of macrophages, although it is also expressed on Kupffer and Langerhans cells. The expression of F4/80 antigen is upregulated on bone marrow cells stimulated in vitro with the macrophage colony stimulating factor. The F4/80 antigen is a requirement for the induction of CD8 T cells-mediated peripheral tolerance.

Supplier: BIOGEMS INTERNATIONAL INC.

The LTF-2 monoclonal antibody is used as an Isotype Control immunoglobulin for rat IgG2b antibodies.

Supplier: BIOGEMS INTERNATIONAL INC.

The 2A3 antibody was obtained by hybridization of MouseNS-1 myeloma cells with spleen cells harvested from BALB/c mice immunized with phytohemagglutinin-activated human T cells. The 2A3 antibody is a CD25 clone and used as an Isotype Control for rat IgG2a antibodies.

Supplier: BIOGEMS INTERNATIONAL INC.

The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the α subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.

Supplier: BIOGEMS INTERNATIONAL INC.

The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.

Supplier: BIOGEMS INTERNATIONAL INC.

The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.

Supplier: BIOGEMS INTERNATIONAL INC.

The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, γδ TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role.

Supplier: BIOGEMS INTERNATIONAL INC.

The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.

Supplier: BIOGEMS INTERNATIONAL INC.

The TER-119 monoclonal antibody specifically binds to the mouse 52 kDa Glycophorin A expressed on the erythroid lineage cells, from the early proerythroblast to mature erythrocyte stages, in the fetal liver, adult bone marrow, newborn liver, yolk sac, and adult lymphoid organs. The TER-119 antibody is used, together with other antibodies, as a marker for hematopoietic lineages cells. 

Supplier: BIOGEMS INTERNATIONAL INC.

The 11B11 monoclonal antibody specifically reacts with mouse 14 kDa cytokine IL-4, expressed by the activated NKT cells and mast cells. IL-4 is species-specific and stimulates the proliferation and differentiation of B lymphocytes. It upregulates the expression of IgE receptors and class II MHC antigen.The 11B11 antibody neutralizes the IL-4 cytokine.

Supplier: BIOGEMS INTERNATIONAL INC.

The 2F1 monoclonal antibody is specific for the mouse Killer cell Lectin-like Receptor G1 (KLRG1), a homodimer consisting of two N-glycosylated subunits of 30-38 kDa, also known as MAFA (Mast cell Function-associated Antigen). The antigen contains a cytoplasmic motif similar to ITIM (the immunoreceptor tyrosine-based inhibitory motif). KLRG1 is a receptor for cadherin, a family of transmembrane glycoproteins that mediate cell adhesion, and a common marker of T cell senescence. The receptor is believed to play an important role in the innate and adaptive immune system through the regulation of leukocytes. It is expressed on lymphokine-activated killer (LAK) cells, adherent LAK (A-LAK) cells, a sub-set of natural killer (NK) cells, T cells. In NK cells, it inhibits cytokine production and cytotoxicity activity.The receptor expression was not detected on the mouse peritoneal mast cells, or bone marrow mast cells.

Supplier: BIOGEMS INTERNATIONAL INC.

The F38-2E2 monoclonal antibody specifically reacts with human T cell immunoglobulin and mucin domain containing protein (TIM3), a transmembrane molecule found on monocytes, macrophages, dendritic cells, and activated T cell types such as Treg, Th1, and Th17. TIM3 can exist in soluble and membrane bound forms and the relevant ligand for the protein is Galectin-9. It plays a role in the creation of immunological tolerances, the secretion of Th1 and Th17 related cytokines, and HIV infection.

Supplier: BIOGEMS INTERNATIONAL INC.

CHIR 99021 is an aminopyrimidine derivate that is a selective and potent inhibitor of glycogen synthase kinase 3 (GSK-3)

Supplier: BIOGEMS INTERNATIONAL INC.

The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes, and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD 28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes.The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production.

Supplier: BIOGEMS INTERNATIONAL INC.

The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, γδ TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role. BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

Supplier: BIOGEMS INTERNATIONAL INC.

The HIT2 monoclonal antibody specifically bind to human CD38, a 45kda type II transmembrane glycoprotein. CD38 is expressed on activated T cells, plasma cells, monocytes, macrophages, dendritic cells, and thymocytes. CD38 displays cyclase and hydrolase enzymatic activity and is involved in lymphocyte adhesion, activation, and cell signaling. Its ligand is CD31.

Supplier: BIOGEMS INTERNATIONAL INC.

The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, γδ TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role.

Supplier: BIOGEMS INTERNATIONAL INC.

The 2H5 monoclonal antibody specifically reacts with mouse, rat, human MCP-1 (Monocyte Chemoattractant Protein-1), also known as CCL2 and MCAF (Monocyte Chemotactic and Activating Factor). MCP-1 is a C-C (beta) chemokine that regulates cytokine production in monocytes and the expression of adhesion molecules. The 2h5 antibody can neutralize the bioactivity of recombinant or natural MCP-1.

Supplier: BIOGEMS INTERNATIONAL INC.

The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-γ) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-γ plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-α, to inhibit proliferation of normal and transformed cells. IFN- γ is the primary cytokine that defines Th-1 cells.The biological activity of IFN-γ is not affected by glycosylation.

Supplier: BIOGEMS INTERNATIONAL INC.

The 4S.B3 is a neutralizing antibody that binds with the human Interferon-gamma (IFN-γ) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-γ plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-α, to inhibit proliferation of normal and transformed cells. IFN- γ is the primary cytokine that defines Th-1 cells.The biological activity of IFN-γ is not affected by glycosylation