"Anaspec"

Supplier: Anaspec

Dynorphins are a class of opioid peptides that arise from the precursor protein prodynorphin. Upon cleavage by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-endorphin. Dynorphins exert their effects primarily through the κ-opioid receptor (KOR), a G-protein-coupled receptor. Dynorphin has been shown to be a modulator of pain response, involved in drug addiction and appetite control.
Sequence:Biotin-YGGFLRRIRPKLKWDNQ
MW:2373.8 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec

This is Oxytocin (OT) N-terminally labeled with Biotin. OT is a 9-amino acid peptide that is synthesized primarily in the hypothalamic neurons, specifically the magnocellular oxytocin neurons in the supraoptic and paraventricular nuclei and is secreted by the posterior pituitary gland. It is also secreted from other tissues, such as the ovaries and testes. Circulating OT is important during parturition and lactation. In the pregnant uterus, oxytocin and the oxytocin receptor play a major part for uterine contractility and the induction of labor. OT is also involved in complex social behaviors such as affiliation, sexual behavior, social recognition, stress buffering, aggression, and trust.
Sequence: Biotin-CYIQNCPLG-NH2 (Disulfide bridge: 1-6)
MW: 1234.5 Da
% Peak area by HPLC: 95
Storage condition: -20° C

Supplier: Anaspec

Cecropin A is a naturally occurring, linear, cationic, 37-residue antimicrobial peptide. Cecropin A kills bacteria by dissipating transmembrane electrochemical ion-gradients.
Sequence:KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK-NH2
MW:4003.8 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec

Cecropin B is a small antibacterial peptide from the giant silkmoth, Hyalophora cecropia. Antimicrobial peptides are essential to innate host defense as effectors of pathogen clearance and can affect host cell to promote wound repair.
Sequence:KWKVFKKIEKMGRNIRNGIVKAGPAIAVLGEAKAL-NH2
MW:3834.7 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec

Aß (1-40) together with Aß (1-42) are two major C-terminal variants of the Aß protein constituting the majority of Aßs. These undergo post-secretory aggregation and deposition in the Alzheimer’s disease brain.
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Molecular Weight: 4329.9 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Supplier: Anaspec

C-type Natriuretic Peptide (CNP), identified in 1990 and called C-type (in order to maintain the alphabetical nomenclature of natriuretic peptides), is the most highly conserved of natriuretic peptides between species. It is derived from a 126 amino acid preprohormone. CNP exists in two mature forms, one found in tissues, another in plasma and cerebrospinal fluid. It is present in high concentration of the vascular tree, especially the endothelium, central nervous tissues, and renal tubular cells. It is a powerful vasorelaxant and inhibitor of smooth muscle cell proliferation and may play a role in coagulation and fibrinogenesis by modulating endothelial cells.
Sequence:GLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge: 6-22)
MW:2197.7 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C

Supplier: Anaspec

This peptide mimics the N terminus of the alpha-chain of fibrin. It binds to the 'a' polymerization pocket in the alpha-chain more tightly than a peptide corresponding to the chain native sequence GPRV. The complex between GPRP and fibrinogen causes an increased resistance to degradation by plasmin, and the polymerization reaction is depressed by the addition of excess peptide. Fibrin assembly, as well as the acceleration of the factor XIIIa reaction, can be prevented by this homologue of the natural sequence of amino acids.
Sequence:GPRP
MW:425.5 Da
%Peak area by HPLC:≥95%
Storage condition:

Supplier: Anaspec

This 14-residue peptide toxin from the wasp venom is originally found as a histamine releaser from mast cells. It induces mitochondrial membrane permeabilization via a CsA-inhibitable mechanism.
Sequence:INLKALAALAKKIL-NH2
MW:1478.9 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec

Scrambled control peptide of beta-amyloid are often used in studies to compare the effects of wild type Beta-Amyloid (1-40).

Supplier: Anaspec

Sequence: KKPYIL
MW: 761 Da
% peak area by HPLC: 95%
Storage condition: -20°C

Supplier: Anaspec

This biotinylated Aß(1-42) contains an 6-carbon long chain (LC) to provide more accessibility for avidin attachment.
Sequence: Biotin-LC-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
MW: 4853.6 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Supplier: Anaspec

This biotinylated Aß(1-40) contains a 6-carbon long chain (LC) to provide more accesibility for avidin attachment.

Supplier: Anaspec

Solid Aß (1-43) fibril is the most fibrillogenic of all the Aß peptides known.
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIAT
Molecular Weight: 4615.2 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Supplier: Anaspec

A number of Aß fragments including Aß (10-20) enhances aggregation of Aß (1-40). All the Aß peptides that enhance aggregation contain either residues 17 to 20 or 30 to 35, indicating the importance of these regions for promoting aggregation of full-length Aß.
Sequence: YEVHHQKLVFF
Molecular Weight: 1446.7 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Supplier: Anaspec

CREBtide is a synthetic substrate for PKA (Km = 3.9 µM). This peptide is based on the phosphorylation sequence in δ-CREB (cAMP response element binding protein).
Sequence:KRREILSRRPS-pY-RK
MW:1925.2 Da
% peak area by HPLC:95
Storage condition:-20° C

Supplier: Anaspec

An H-2b-restricted OVA class II epitope.
Sequence: ISQAVHAAHAEINEAGR
MW: 1773.9 Da
% Peak Area by HPLC: ≥ 95%
Storage condition: -20°C