"Adipogen"

Supplier: Adipogen

Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.

Supplier: Adipogen

Human CD53 is a tetraspan cell surface glycoprotein found on all hemopoetic cells except platelets and red blood cells.

Supplier: Adipogen

Beauvericin is an antibiotic apoptosis inducer.

Supplier: Adipogen

The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumor progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor.

Supplier: Adipogen

BMS-2 is a potent MET kinase inhibitor with an IC(50) value of 1.8nM. It also possesses potent inhibitory activity against Flt-3 and VEGFR-2 kinases, IC(50) values of 4nM and 27nM respectively.

Supplier: Adipogen

A neonicotinoid insecticide. Compound can be used as analytical reference material.

Supplier: Adipogen

RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

Supplier: Adipogen

Widely used blue fluorescent thiol-reactive dye (Ex/Em: 384/470nm). This maleimide derivative of coumarin is essentially non-fluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. Good energy acceptor from tryptophan and a good energy donor to fluorescein. Used to monitor release of thiols and to distinguish proliferating cancer cells by nucleolar protein staining.

Supplier: Adipogen

Anticancer. Apoptosis inducer and cell proliferation inhibitor. Autophagy inducer. Anti-angiogenic. VEGF/VEGFR-2 signaling inhibitor. Antioxidant and antibacterial. AMPK-mediated GSK3beta inhibitor. Anti-inflammatory. Inhibits translocation and activation of NF-kappaB by blocking phosphorylation and subsequent degradation of IkappaBalpha. Downregulates TRIF-dependent signaling pathways of TLRs by inhibiting TBK1 kinase activity. Blocks LPS-induced TLR4/MD2 complex signaling. NLRP3 inflammasome activation inhibitor. Inhibits NLRP3-activated ASC oligomerization. Can block the NLRP3 inflammasome at both the priming step and the activation step. H(2) histamine receptor signaling inhibitor. Anti-diabetic. Antihyperglycemic. Aldose reductase inhibitor. Vasorelaxant. Soluble guanylyl cyclase activator. GABAA receptor positive allosteric modulator. Potent cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor. Shown to inhibit breast cancer stem cells through WIF1 demethylation. Shows outstanding matrix properties for MALDI-TOF-MS analysis of oligosaccharides.

Supplier: Adipogen

Human CD58 is a cell surface glycoprotein with wide distribution on hemopoietic cells and functions as an adhesion molecule mediating a costimulatory signal through CD2. CD58 is attached to the cell surface by either of two forms - transmembrane or GPI.

Supplier: Adipogen

A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Plays a role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. It acts through a heterodimeric receptor comprising the ecdysone receptor and the ultraspiracle proteins (USP). Appears in plants mostly as a protection agent (toxins or antifeedants) against herbivorous insects. Could be used for controlled gene expression in scientific research, agriculture and medicine. Could be used for the development of selective insect growth regulators for use as environmentally benign insecticides.

Supplier: Adipogen

Labeling reagent for protein thiols for cytofluorescence.

Supplier: Adipogen

Human CD154 (CD40 ligand) is a member of the TNF family and is expressed on the surface of activated T cells. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function. CD154 has been shown to be hyperexpressed by B and T cells in SLE patients. CD154 has been reported to be expressed on vascular endothelial cells, smooth muscle cells and macrophages indicating a possible role for the CD40-CD154 immunoregulatory signaling mechanism during inflammation and immunity in atherogenesis.

Supplier: Adipogen

Chemiluminescent probe for the detection of peroxides in biological systems. Reagent used for the generation of chemiluminescence in the presence of a reductant and oxygen It is employed in numerous chemiluminescent assays. Lucigenin is specific for superoxide anion radical.

Supplier: Adipogen

Giantin, the largest Golgi membrane protein, is C-terminally anchored to cis- and medial-Golgi membranes and forms a long ~250nm coiled-coil rod that directly interacts with microtubules in a cell-cycle regulated way. It is an excellent marker for mammalian golgi complex. It is also an antigen in chronic rheumatoid arthritis and in the autoimmune disease Sjoegren syndrome.

Supplier: Adipogen

Phenoxy herbicide. Synthetic auxin. Compound can be used as analytical reference material.