4829 Results for: "Adipogen"

Supplier: Adipogen

Antibiotic

Supplier: Adipogen

Antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor. Axonal cytoskeleton modulator. Inhibitor of autophagosome-lysosome fusion. Apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.

Supplier: Adipogen

Potent immunosuppressant (same as FK-506 and rapamycin)

Supplier: Adipogen

Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.

Supplier: Adipogen

Potent and selective endothelin receptor A (ETA) antagonist. Suppresses the ET-1-induced decrease of LPL activity. Shows protective effects in ischemic acute renal failure. Neuroprotective. Anti-hypertensive. Inhibits ET-1 receptor binding and blocks Ca2+ mobilization, cellular contraction and MAP kinase activation. Cardiovascular agent. Reduces myocardial infarct size and oxidant injury. Selected Reviews.

Supplier: Adipogen

Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1a is the major ganglioside of the nervous system. It is converted to GM1 by bacterial, viral and mammalian sialidases. It is a differentiation marker for cell growth.

Supplier: Adipogen

Potent and selective endothelin B receptor (ETBR) antagonist.

Supplier: Adipogen

Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (PGPH) (caspase-like) activity of the 20S proteasome. Excitation: 380nm. Emission: 460nm.

Supplier: Adipogen

Potent and selective inhibitor of cyclin dependent kinases CDK1, CDK2, CDK5 and CDK9. Apoptosis inducer. Inhibits the proliferation of various cancer cell lines. Casein kinase 1 (CK1delta/epsilon) inhibitor. Potential anti-inflammatory compound. Potential antidiabetic compound.

Supplier: Adipogen

N-methylated inactive control compound for 7BIO . Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Supplier: Adipogen

Potent inhibitor of DYRKs and CLKs. Interacts also with GSK-3alpha/beta, CK2 and PIM1. Interacts with the complex PIKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Tools to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death. Autophagy activator.

Supplier: Adipogen

Potent stimulator of invariant natural killer T (iNKT) cells. Induces strong antitumor immunity through a nitric oxide (NO) and TNF-alpha dependent mechansim, different compared to the IFN-gamma dependent mechanism of alpha-GalCer (AG-CN2-0014). Does not induce anergy of iNKT cells.

Supplier: Adipogen

Immunostimulant. Potent stimulator of natural killer T (NKT) cells. Specific ligand of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells. Potent antitumor compound. Stimulates the production of smaller amounts of IFN-gamma than alpha-GalCer, but induces equal or greater IL-4 secretion in mouse models.

Supplier: Adipogen

Potent antiprion agent. Higher activity than 6-Aminophenanthridine . Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome. Inhibitor of protein aggregation.

Supplier: Adipogen

Beta-Aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine. beta-Aminoisobutyric acid occurs in two isomeric forms and both enantiomers of beta-Aminoisobutyric acid can be detected in human urine and plasma. In plasma, the S-enantiomer is the predominant type due to active renal reabsorption. In contrast, urine almost exclusively contains the R-enantiomer of beta-Aminoisobutyric acid, which is eliminated both by filtration and tubular secretion. The S-enantiomer of beta-Aminoisobutyric acid is predominantly derived from the catabolism of valine, the R-enantiomer is the product of the catabolism of the pyrimidine bases uracil and thymine by the enzyme dihydropyrimidine dehydrogenase (DPD), in what constitutes the first step of the pyrimidine degradation pathway. Transient high levels of beta-Aminoisobutyric acid have been observed under a variety of pathological conditions such as lead poisoning, starvation, in total body irradiation and in a number of malignancies. Recently R-/S-enantiomer mixtures have been shown to be browning inducer of white adipose tissue.

Supplier: Adipogen

Anhydrotetracycline hydrochloride is a tetracycline derivative.

Supplier: Adipogen

Amine used as chiral and organic building block.

Supplier: Adipogen

Potent inhibitor of ethylene synthesis in plants acting at the level of 1-aminocyclopropanecarboxylic acid synthase.

Supplier: Adipogen

Amino derivative of biotin that can be used as an intracellular label for cells, particularly neurons. It is used for neuronal tracing studies by visualizing neural architecture and for the identification of gap junction coupling. It is better soluble and non-toxic compared to other neuronal labels. It remains longer in cellsand can be fixed with formalin or glutaraldehyde. It can be detected using avidin or streptavidin systems with either chromogenic or fluorescence visualization methods.

Supplier: Adipogen

Functionalized biotin. Biotinylated polyethylene glycol (PEG-Biotin) is an avidine or streptavidin reactive PEG derivative that can be used to modify biomolecues or other surfaces through biotin-streptavidin interaction. Used for addition of biotin-PEG to the N-terminus of resin-bound peptides. Can be introduced using standard coupling methods, such as PyBOP or TBTU and has better solubility in DMF and NMP than comparable non-PEG-containing derivatives, such as biotin-Ahx and biocytin.

Supplier: Adipogen

Enzyme substrate.

Supplier: Adipogen

Excellent amino-reactive tag that has strong blue fluorescence. Can be used to create blue-fluorescent bioconjugates with an excitation/emission spectra of ~358/410 nm. Used to label neuropeptides, peptides, nucleotides and cells.

Supplier: Adipogen

N-methyl-4-hydrazino-7-nitrobenzofurezan (MNBDH) is a new reagent for the determination of aldehydes and ketones. MNBDH reacts with carbonyl copmounds in acidic media to the corresponding MNBD-hydrazones. For example formaldehyde hydrazone formed is determined by high-performance liquid chromatography with UV/visible detection at 474 nm. MNBDH has been studied recently as a reagent with reduced interferences by ozone and nitrogen dioxide. It reacts with these oxidants to give only one product N-methyl-4-amino-7-nitrobenzofurezan (MNBDA).

Supplier: Adipogen

Triplet probe used for the measurment of rotational diffusion of protein in solution and in membranes, includin myosin and pyruvate dehydrogenase.

Supplier: Adipogen

Anionic membrane probe used for studies on the uptake of fluorescent fatty acids into cultured cells and oxygen sensing.

Supplier: Adipogen

Hydrogen sulfide (H2S) is an important gaseous mediator, like nitric oxide, that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. WSP-1 is a reactive disulfide-containing, fluorescent probe designed to detect H2S in biological samples and cells. Through a reaction-based fluorescent turn-on strategy, WSP-1 selectively and rapidly reacts with H2S to generate benzodithiolone and a fluorophore with excitation and emission maxima of 465 and 515 nm, respectively.

Supplier: Adipogen

PIK-75 is a PI3K inhibitor displaying selectivity for the p110alpha isoform (IC(50) of 6nM). PIK-75 blocks the phosphorylation of PKB induced by insulin.

Supplier: Adipogen

PD173955-Analog1 is a potent c-Src inhibitor with an IC(50) value of 9nM. It is also a weaker inhibitor of PDGFR, FGFR and EGFR with IC(50) values of 130nM, 110nM and 190nM respectively.

Supplier: Adipogen

BMS387032 is a novel cyclin-dependent kinase inhibitor, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. It inhibits CDK2 with an IC(50) of 48nM and up to 20-fold selective over CDK1/CDK4. It also inhibits CDK7/9 with IC(50) values of 62nM and 4nM. It has little effect on CDK6.

Supplier: Adipogen

IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.