N-Hexadecanoyl-DL-homoserine lactone ≥97% (by GC)
Supplier: Adipogen
N-Hexadecanoyl-DL-homoserine lactone (C16-HSL) is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. C16-HSL is a lipophilic, long acyl side-chain bearing AHL, produced by the LuxI AHL synthase homolog SinI involved in quorum-sensing signaling in S. meliloti, a nitrogen-fixing bacterial symbiont of certain legumes. C16-HSL is the most abundant AHL produced by the proteobacterium R. capsulatus and activates genetic exchange between R. capsulatus cells. It tends to localize in relatively lipophilic cellular environments of bacteria and cannot diffuse freely through the cell membrane. The long-chain N-acylhomoserine lactones may be exported from cells by efflux pumps or may be transported between communicating cells by extracellular outer membrane vesicles.
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N-Hexanoyl-DL-homoserine lactone ≥97% (by GC)
Supplier: Adipogen
N-Hexanoyl-DL-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression and affecting cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general and in cystic fibrosis, infection prevention, slime and biofilm reduction in commercial agriculture and aquaculture industries, food spoilage prevention and septicemia in fish.
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9-(Hydroxymethyl)-10-carbamoylacridan ≥98% (by HPLC)
Supplier: Adipogen
Major intermediate in carbamazepine metabolism. This carbamazepine metabolite can be used as a reference compound.
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Josamycin (synthetic) ≥98% (by UV method)
Supplier: Adipogen
Josamycin is a member of the leucomycin family of macrolide antibiotics.
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10-Octadecylacridine orange bromide
Supplier: Adipogen
Fluorescent reagent with high selectivity. Potential sensitive dye (PSD) to monitor differences in cell potential as they occur during ion transport through the cell membrane.
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Rhodamine B octadecyl ester perchlorate
Supplier: Adipogen
Sensitive membrane dye used for potassium (fiber-optic sensors) and nitrate sensing and other investigations of membranes. Lipophilic energy transfer acceptor from lipophilic fluoresceins in fluorescence energy transfer (FRET) assays in cell fusion experiments (Ex/Em: 554/575nm in methanol).
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Novaluron ≥98% (by HPLC)
Supplier: Adipogen
Acylurea insecticide. Insect growth inhibitor. Chitin synthase inhibitor active against larvae of Coleoptera, Homoptera, Diptera and Lepidoptera. Shown to be an inhibitor of acetylcholinesterase in B-biotype Bemisia tabaci. Compound can be used as analytical reference material.
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4-(Trifluoromethyl)umbelliferyl phosphate ≥90% (by HPCE)
Supplier: Adipogen
Suitable as fluorogenic substrate for alkaline phosphatase.
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Tris[3,5-bis(trifluoromethyl)phenyl]phosphine
Supplier: Adipogen
A phosphine with enhanced solubility in solvents. Phosphines are used as ligands for many metal complexes.
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4-(Trifluoroacetyl)benzoyl chloride ≥97% (by GC)
Supplier: Adipogen
Building block for synthesis.
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Tivozanib ≥95%
Supplier: Adipogen
Tivozanib is a potent inhibitor of VEGFR-1, 2 & 3 (IC(50) 0.21, 0.16 and 0.24nM respectively).
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BX-795 ≥95%
Supplier: Adipogen
BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC(50) 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-epsilon. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC(50) values ranging from submicromolar amounts (0.368µM to greater than 450µM.
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JNJ-38877605 ≥95%
Supplier: Adipogen
JNJ38877605 is an orally bio-available, small-molecule, c-MET tyrosine kinase inhibitor with potential anti-neoplastic activity. It is potent (c-MET enzyme and Phospho-MET IC(50) values of 4nM and 50nM, respectively) and highly specific (selective over 229 other kinases tested).
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KU-0063794 ≥95%
Supplier: Adipogen
KU0063794 is a highly specific inhibitor of the mammalian target of rapamycin (mTOR). It inhibits both mTORC1 and mTORC2 with an IC(50) of approximately 10nM.
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2-Ethoxy-2-(2-naphthyl)-acetonitrile ≥95% (by HPLC)
Supplier: Adipogen
This is a new substrate for Cytochrom P450 suitable for fluorescence assays.
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6-FITC DA ≥95% (by HPLC)
Supplier: Adipogen
Fluorescent reagent with high selectivity.
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5-Fluorocytosine
Supplier: Adipogen
Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil (a widely used cytotoxic drug) and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors.
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Fluorescein octadecyl ester ≥97% (by TLC)
Supplier: Adipogen
Chromoionophore XI is used as a lipophilic fluorescent pH indicator.
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H-Met-AMC ≥99% (by HPLC, sum of enantiomers)
Supplier: Adipogen
Substrate for calpain.
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Mesuximide ≥98% (by GC)
Supplier: Adipogen
A succinimide with anti-epileptic and anti-convulsant properties. The mechanisms of action are unknown and possibly multiple. Metabolically reduced to it's pharmacologically active metabolite N-desmethylmethosuximide.
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8-Amino-2-naphthol
Supplier: Adipogen
Chiral organo-catalyst. Chiral primary amine that can be used for the direct alpha-fluorination of alpha-branched aldehydes. Building block for synthesis.
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9,10-Anthracenediyl-bis(methylene)dimalonic acid ≥90% (by HPCE)
Supplier: Adipogen
Reagent for the assay of O2 with better characteristics than 9,10-anthracenediyl-bis-dipropionic acid.
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(-)-Cytisine
Supplier: Adipogen
Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking cessation. Iron-chelator and hydroxyl radical scavanger. Has antidepressant properties. Used in forensics in novel surface molecular imprinting techniques.
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4-(N,N-Diethylaminomethyl)-7-propoxycoumarin ≥97% (by HPLC)
Supplier: Adipogen
Fluorescent labelling.
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3,3'-Dipropylthiacarbocyanine iodide
Supplier: Adipogen
Carbocyanine dyes, particularly thiacyanines such as DiSC3(3) can inhibit respiration and may therefore be relatively cytotoxic. 3,3'-dipropyl-thiadicarbocyanine iodide is sensitive to membrane potential, fluorescence response to depolarization depends on the staining concentration and detection method. Selected applications are: -Calcium channels and other ion transport systems -Mitochondrial activity -Neurons and brain tissue -Membrane potential in intact yeast cells
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DACB-CN ≥90% (by HPCE)
Supplier: Adipogen
Analytical reagent for chromatography. Derivatization reagents.
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DAABD-AE ≥95% (by HPLC)
Supplier: Adipogen
4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-(2-aminoethylamino)-2,1,3-benzoxadiazole (DAABD-AE) is new derivatization reagent for rapid and specific liquid chromatography tandem mass spectrometric quantification of pristanic acid, phytanic acid, and very long chain fatty acids (i.e. hexacosanoic, tetracosanoic, and docosanoic acids) in plasma.
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4-(N,N-Dimethylaminomethyl)-7-propoxycoumarin ≥97% (by HPLC)
Supplier: Adipogen
Fluorescent labelling.
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Poly(D-lactide), M.W. 90000-124000 g/mol, (max. 0.5% H₂O)
Supplier: Adipogen
Poly(D-lactide) (PDLA), a polymer of a stereospecific cyclic di-ester of lactic acid, is used in biomaterial research for the development of devices such as therapeutic drug delivery vessels. Poly(D-lactide) is used for the preparation of microparticles and resorbable polylactide scaffolds.