4829 Results for: "Adipogen"

Supplier: Adipogen

Human CD63 is expressed on activated platelets and also on monocytes and macrophages. CD63 contains four hydrophobic transmembrane regions and is a member of the tetraspan family. CD63 appears to be involved with cell adhesion and associates with VLA-3 and VLA-6 integrins. In a colon cancer model, it has been correlated to metastatic potential.

Supplier: Adipogen

Human CD58 is a cell surface glycoprotein with wide distribution on hemopoietic cells and functions as an adhesion molecule mediating a costimulatory signal through CD2. CD58 is attached to the cell surface by either of two forms - transmembrane or GPI.

Supplier: Adipogen

Human CD57 originally called HNK-1, is a glycoprotein found on 15-20 % of PBL’s (peripheral blood lymphocytes) including 60 % of NK cells and a subset of T cells. The immune regulation role of CD57 positive PBL’s expressing high levels of CD8 is being investigated.

Supplier: Adipogen

Human CD57 originally called HNK-1, is a glycoprotein found on 15-20 % of PBL’s (peripheral blood lymphocytes) including 60 % of NK cells and a subset of T cells. The immune regulation role of CD57 positive PBL’s expressing high levels of CD8 is being investigated.

Supplier: Adipogen

Human CD56 is an adhesion molecule from the Ig superfamily which is restricted to NK cells in the immune system. It is believed that NK cells form a first line of defense against tumor cells and cells infected with bacteria and viruses.

Supplier: Adipogen

Human CD54 (ICAM-1) mediates cell adhesion by binding to the integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). CD54 expression on resting peripheral blood leukocytes is weak but is upregulated on activated T and B lymphocytes and on monocytes.

Supplier: Adipogen

Immunoglobulin expressed by the mouse plasmacytoma MOPC 31C is an IgG1kappa isotype of unknown specificity. It is used as a negative control when working with human cells.

Supplier: Adipogen

Immunoglobulin expressed by the mouse plasmacytoma hybridoma SIPC 3385 is an IgG3 isotype of unknown specificity. It is used as a negative control when working with human cells.

Supplier: Adipogen

Immunoglobulin expressed by the mouse plasmacytoma hybridoma BPC 4 is an IgG2bkappa isotype of unknown specificity. It is used as a negative control when working with human cells.

Supplier: Adipogen

Human IgG1kappa from human myeloma plasma is used as a negative control for work involving human IgG1 isotype antibodies or recombinant proteins.

Supplier: Adipogen

CD274 (B7-H1; PD-L1; Programmed Death Ligand) is a member of the B7 family and is expressed on a variety of tissues including lymphoid cells. It plays an important role in regulation of T cell activation and is involved in progression of cancer, arthritis and HIV infection. CD274 binding to its receptor CD279 (PD-1) on activated T cells can decrease proliferation. Conversely, ligation of CD279 on primed T cells can stimulate IL-10 production. High levels of CD274 present in renal cell carcinoma is associated with poor prognosis. Tumor expressed CD274 can increase apoptosis of tumor specific T cells resulting in better tumor cell survival.

Supplier: Adipogen

Human CD134 (OX40; ACT35) is an activation-associated antigen which is predominantly expressed on activated CD4 positive cells. CD134 antigen is a member of the TNF receptor family of molecules and may be involved with regulating T cell-dependent B cell proliferation and differentiation.

Supplier: Adipogen

Human CD100 is a transmembrane glycoprotein that belongs to the semaphorin gene family and is found on most hematopoietic cells except RBC, platelets and immature bone marrow cells. CD100 plays a key role in lymphocyte activation. Interaction of CD100 with its ligand CD72 has implications in the mechanism of NK cell killing.

Supplier: Adipogen

Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation. CD137 is a type I membrane protein and a member of the TNF receptor superfamily. CD137 appears to be important for T cell proliferation and survival and induces monocyte activation.

Supplier: Adipogen

TNF (Tumor necrosis factor; cachexin; cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction.

Supplier: Adipogen

Human CD137L (4-1BB ligand) is a type II transmembrane protein constitutively expressed by monocytes, B cells and neuroblastoma cells. Binding of CD137 (4-1BB) to CD137L induces monocyte activation.

Supplier: Adipogen

Human CD137 (4-1BB) is expressed on activated T cells within 24-48 hours of activation. CD137 is a type I membrane protein and a member of the TNF receptor superfamily. CD137 appears to be important for T cell proliferation and survival and induces monocyte activation.

Supplier: Adipogen

Human CD40 is a member of the TNF receptor family and is present on all B cells except plasma cells. CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 plays an important role in B cell activation and the interaction with its ligand CD154 (CD40 ligand) is essential for isotype switching.

Supplier: Adipogen

Human CD152 (CTLA-4) is a cell surface glycoprotein expressed at low levels on activated T cells. CD152 is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and appears to function as a negative regulator of T cell activation. This product is a soluble fusion protein combining the extracellular (125aa) domain of human CD152 and murine IgG2a Fc (CTLA-4 Ig).

Supplier: Adipogen

Human CD39 is found on most mature B cells, activated NK cells and activated T cells, as well as neutrophills and monocytes. CD39 has homology to the N-myc family of proteins and has been cloned. CD39 is an ecto apyrase. A lower expression level of CD39 on T and NK cells have been observed in hypertensive individuals.

Supplier: Adipogen

Human CD38 is a type II transmembrane glycoprotein with bifunctional ectoenzyme activity catalyzing both synthesis and hydrolysis of cyclic ADP ribose. CD38 is involved in lymphocyte activation and adhesion to endothelium and has been identified as a counter-receptor of CD31.

Supplier: Adipogen

Human CD37 is a member of the tetraspan family of cell surface molecules that apparantly are involved in signal transduction or transporter system complexes. CD37 is strongly expressed on B lymphocytes (sIg-positive) and weakly on T cells, neutrophils and monocytes. Expression of CD37 disappears during B cell development at the plasma cell stage.

Supplier: Adipogen

Human CD34 is an unusual glycosylated membrane protein exclusively expressed on immature hematopoietic cells and on endothelial cells. CD34 may have a role in cell adhesion. CD34 has extensive utility for bone marrow transplantation.

Supplier: Adipogen

Human CD43 is a heavily O-glycosylated and sialylated transmembrane protein that is mainly found on T cells, but not on B cells.

Supplier: Adipogen

Human CD79a is a 22kDa glycoprotein which associates with CD79b to form a functional heterodimer that interacts with membrane immunoglobulin (mIg).The mIgM component binds antigen and the heterodimer transduces signals.

Supplier: Adipogen

Goat anti-mouse/FITC is reactive with mouse Ig subclasses: G1, G2a, G2b, G3. It also reacts well with mouse IgM antibodies. Reagent does not bind significantly to any human cells or cell lines tested.

Supplier: Adipogen

The cytokine human interleukin-2 (IL-2) is a 15kDa protein expressed upon activation by peripheral TH1 cells, medullary thymocytes and a subset of large granular lymphocytes. Secreted IL-2 stimulates proliferation and lymphokine production by T cells, B cells and NK cells.

Supplier: Adipogen

Human CD79a is a 22kDa glycoprotein which associates with CD79b to form a functional heterodimer that interacts with membrane immunoglobulin (mIg).The mIgM component binds antigen and the heterodimer transduces signals.

Supplier: Adipogen

Human CD70 is not present on resting lymphocytes. CD70 is expressed after activation on about 20% of T cells and on about 70% of B cells. CD70 is a ligand for CD27 and it is also a member of the TNF gene family.

Supplier: Adipogen

Human CD69 is expressed by platelets and mature thymocytes and appears rapidly after activation on T cells, B cells and NK cells. This pattern of cellular CD69 expression has suggested a lymphocyte activation role. Functional studies with antibodies to CD69 also support an activation role for CD69.