131768 Results for: "6-Bromo-4,4-dimethyl-1,4-dihydrobenzo[d][1,3]oxazin-2-one&amp"

Supplier: ONE WORLD LAB MS

ANTIBODY HUMAN RHOA 10UL

Supplier: NEWARK IN ONE MS

WIRE THERMOCOUPLE TYPE B SOLID 30AWG

Supplier: NEWARK IN ONE MS

CAP SPOOL SMP LEC T/C 5PK

Supplier: NEWARK IN ONE MS

SCREWDRIVER POCKET CLIP 1/8IN 108MM

Supplier: NEWARK IN ONE MS

THERMOCOUPLE 36AWG GUAGE 482C 36IN PK1

Supplier: NEWARK IN ONE MS

INSULATOR CERAMIC 2 HOLE ROUND 6IN 5PK

Supplier: NEWARK IN ONE MS

PROBE SS MQSS FINE SERIES 12/0.062IN

Supplier: AS ONE INTERNATIONAL, INC MS

KIT 3-D LIFE PVA-PEG HYDROGEL SG SLOWGEL

Supplier: NEWARK IN ONE MS

INSULATION CERAMIC NEXTEL T/C ROHS

Supplier: NEWARK IN ONE MS

POWER SOURCE GW INSTEK AC 1000VA

Supplier: MilliporeSigma

Recombinant, human pro-MMP-2 expressed in mouse cells. Useful for immunoblotting, substrate cleavage and assay zymography. The ~72 kDa purified proenzyme MMP-2 may be used as a positive control or standard for zymographic analysis, immunoblotting, or substrate cleavage assays. Requires activation prior to use. Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processes such as angiogenesis, intimal hyperplasia, atherosclerosis and aneurysms. Recently, MMPs have been linked to neurodegenerative diseases such as Alzheimer′s, and amyotrophic lateral sclerosis (ALS). Natural inhibitors of MMPs, tissue inhibitor of matrix metalloproteinases (TIMPs) exist and synthetic inhibitors have been developed which offer hope of new treatment options for these diseases.

Supplier: Promega Corporation

The pNL1.3[secNluc], pNL3.3[secNluc/minP], pNL2.3[secNluc/Hygro] and pNL1.3.CMV[secNluc/CMV] Vectors offer a secreted small luciferase reporter in various promoter-driven or promoterless configurations for expression in mammalian cells.

Supplier: Defibtech

Defibtech AEDs offer industry-leading innovation, simplicity, and elegance.

Supplier: Miele

The PLW 8615 laboratory washer can accommodate 216 laboratory flasks, 588 vials, or 294 pipettes. The large glassware washer is flexible and simple to use, it has modular load carriers and SimpleLoad system. This efficient unit has a single door, 900 mm wide, a usable capacity of 351 litres. PLW 8615 provides reliable results, high pump performance with a variable-speed pump and features spray arm monitoring and a conductivity meter.

Supplier: NEWARK IN ONE MS

THERMOCOUPLE AWG WIRE SIZE 20 12IN 300MM

Supplier: NEWARK IN ONE MS

TUBE WIRE PROTECTION FITS 20 SERIES ROHS

Supplier: DuPont

Tychem® 10000 exhibits excellent chemical barrier properties and offers an extremely durable fabric that is puncture- and tear-resistant.

Supplier: Vector Laboratories

Vector® M.O.M.™ (Mouse on Mouse) Immunodetection Kits combine the flexibility and stability of avidin/biotin complex-based target protein detection with reagents that block interference from endogenous mouse IgG antibodies. Vector® M.O.M.™ ImmPRESS™ Kits combine the high sensitivity and simple protein detection protocol with reagents that block interference from endogenous mouse IgG antibodies.

Supplier: NEWARK IN ONE MS

INSULATOR CERAMIC 2 HOLE ROUND 1/6IN 5PK

Supplier: NEWARK IN ONE MS

WIRE T/C EXTENSION EXGG RS 24 25

Supplier: NEWARK IN ONE MS

PROBE HVY DTY TRANS JOINT OMEGA

Supplier: AS ONE INTERNATIONAL, INC MS

TISSUE LENS CLEANER 3NO 100X150MM PK100

Supplier: Greiner Bio-One

TUBE URINE CCM VACUETTE YL/BK 16X100 9ML

Supplier: NEWARK IN ONE MS

THERMOCOUPLE CONNECTOR CABLE CLAMP SMPW

Supplier: NEWARK IN ONE MS

SCREWDRIVER SLOT BLADE/102MM TIP/4.77MM

Supplier: NEWARK IN ONE MS

INSULATED GLASS LEC 5TC GG KI SMP M

Supplier: Greiner Bio-One

BOTTLE ROLLER 1X 850CM2 FLTR CAP CS48

Supplier: Greiner Bio-One

TUBE URINE CCM VACUETTE YL/BK 13X75 4ML

Supplier: Biosensis

BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family. Antibody reacts with human, mouse, rat, guinea pig BDNF. Expected to detect BDNF from other species due to sequence homology.

Supplier: Genetex

The serum amyloid A family comprises a number of differentially expressed apolipoproteins, acute-phase SAA1 and SAA2, the former being the major component in plasma and constitutive SAAs. Although the liver is the primary site of synthesis of both SAA types extrahepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations; SAA rises earlier and more sharply than CRP. Recently, a broader view of SAA expression and function has been emerging. Expression studies show production of SAA proteins in histologically normal, atherosclerotic, Alzheimer, inflammatory, and tumour tissues. SAA has been found to have binding sites for high density lipoproteins, calcium, laminin, and heparin/heparin sulphate. Also adhesion motifs were identified and new functions affecting cell adhesion, migration, proliferation, and aggregation were discovered. These findings emphasize the importance of SAA in various physiological and pathological processes including inflammation, atherosclerosis, thrombosis, AA-amyloidosis, rheumatoid arthritis, and neoplasia. SAA has also a number of immunomodulatory roles, it can induce chemotaxis and adhesion molecule expression, has cytokine-like properties and can promote the upregulation of metalloproteinases. It enhances the binding of high density lipoprotein to macrophages and thus helps in the delivery of lipids to sites of injury for use in tissue repair, it is thus thought to be an integral part of the disease process.