Anti-MBP Mouse Monoclonal Antibody [clone: 7G7]
Supplier: Biosensis
Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximately 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein (MBP). MBP is an 'intrinsically unstructured' protein with a high proportion (approximately 75%) of random coil, but postulated to have core elements of beta-sheet and alpha-helix. MBP is a major protein in CNS myelin and is expressed specifically in the nervous system. A detailed immunochemical examination of monoclonal and polyclonal antibody responses to MBP and its peptides has revealed the existence of as many as 27 antigenic determinants, many of them conformational. Topological mapping of the potential antigenic determinants onto a model of MBP secondary structure places these determinants within 11 separate regions of the molecule, including those portions that have been found to be encephalitogenic. The message for myelin basic protein is selectively translocated to the ends of the cell processes. Immunization with myelin-associated antigens including MBP significantly promotes recovery after spinal cord contusion injury in the rat model. FUNCTION: Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Myelin membrane; peripheral membrane protein; cytoplasmic side. Cytoplasmic side of myelin. TISSUE SPECIFICITY: Found in both the central and the peripheral nervous system.
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Tamoxifen, white powder
Supplier: MP Biomedicals
Protein kinase C inhibitor (IC50 = 50-200 µM depending on assay conditions in MCF-7 cells or IC50 = 100 µM in rat brain). The PKC inhibition is also dependent on the phosopholipid concentration. Also inhibits both calmodulin-dependent and calmodulin-independent Ca2+-, Mg2+-ATPase. Tamoxifen is a selective estrogen response modifier (SERM), anti-angiogenetic factor. It is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Tamoxifen has been used to facilitate the recombination of ect2flox allele in mouse organs. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation
Tamoxifen is a Protein kinase C inhibitor. It induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
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Orion™ Pro Star EC212 Conductivity Bench Meter
Supplier: Thermo Fisher Scientific
The Thermo Scientific™ Orion™ Pro Star EC212 conductivity bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star EC212 meter delivers advanced performance in a modern and simplified package.
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Orion™ Pro Star PH211 pH/ORP Bench Meter
Supplier: Thermo Fisher Scientific
The Thermo Scientific™ Orion™ Pro Star PH211 pH bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star PH211 meter delivers advanced performance in a modern and simplified package.
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Orion™ Pro Star PI214 pH/Ion Bench Meter
Supplier: Thermo Fisher Scientific
The Thermo Scientific™ Orion™ Pro Star PI214 pH/ion bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star PI214 meter delivers advanced performance in a modern and simplified package.
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L(+)-Potassium sodium tartrate tetrahydrate ≥99.0%, white crystalline powder ACS
Supplier: MP Biomedicals
Potassium sodium tartrate tetrahydrate has been used in organic synthesis to break up emulsions in aqueous workups.
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Orion™ Pro Star PD216 pH/Ion/DO Bench Meter
Supplier: Thermo Fisher Scientific
The Thermo Scientific™ Orion™ Pro Star PD216 pH/ion and dissolved oxygen bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star PD216 meter delivers advanced performance in a modern and simplified package.
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Orion™ Pro Star MP218 pH/Ion/Conductivity/DO Bench Meters
Supplier: Thermo Fisher Scientific
The Thermo Scientific™ Orion™ Pro Star MP218 pH/ion, conductivity, and dissolved oxygen bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star MP218 meter delivers advanced performance in a modern and simplified package.
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Unit dose sample die for Model IC
Supplier: GLOBEPHARMA
Unit-dose and bulk powder, liquid, and semi-solid samplers available in various lengths and configurations.
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Model I, unit dose powder sampler, single sample design, single port at 1.5" from tip
Supplier: GLOBEPHARMA
Unit-dose and bulk powder, liquid, and semi-solid samplers available in various lengths and configurations.