Supplier: Bioss

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.

Supplier: Vileda Professional - FHP

SpillEx Pads are the ideal solution for spill pickup or equipment leaking, makes free from the risk of cross contamination.

Supplier: SW Safety Solutions

Engineered for life science environments, these durable gloves provide protection from chemicals without sacrificing the grip or dexterity needed to handle fine work details with full confidence.

Supplier: Mettler Toledo

The XPR26PC allows fast and highly accurate pipette verifications according to ISO8655 for volumes between 1 and 100 µl. Supported by status light, level control, and internal calibration, producing reliable results every time.

Supplier: Prosci

NIK Antibody: Nuclear factor kappa B (NF-kappa B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNF alpha , LPS and mitogens. A serine/threonine protein kinase which mediates NF-kappa B activation by IL-1, TNF alpha and CD95 was identified recently and designated NIK (for NF-kappa B inducing kinase). NIK is an activator of I kappa B kinase alpha and beta (IKK alpha and IKK beta ). Therefore, NIK is a key molecule in the NF-kappa B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

Supplier: Prosci

NIK Antibody: Nuclear factor kappa B (NF-kappa B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha , LPS and mitogens. A serine/threonine protein kinase which mediates NF-kappa B activation by IL-1, TNFalpha and CD95 was identified recently and designated NIK (for NF-kappa B inducing kinase). NIK is an activator of Ikappa B kinase alpha and beta (IKKalpha and IKKbeta ;). Therefore, NIK is a key molecule in the NF-kappa B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

Supplier: Promega Corporation

Recombinant full-length human PDK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. PDK1 (3-phosphoinositide-dependent protein kinase) is activated by the presence of PtdIns(3,4,5)P3 or PtdIns(3,4)P2.

Supplier: Rockland Immunochemical

YPEL4 (yippee-like 4) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL4 is ubiquitously expressed in adult tissues and has been shown to associate with the major vault protein (MVP). It has been suggested that MVP can inhibit YPEL4's ability to activate Elk-1 in the MAPK signaling pathway.

Supplier: AVIDITY SCIENCE

Two-In-One system provides DI water to a storage tank and ultrapure water through dispensing gun.

Supplier: Sartorius

These Cubis® II premium high capacity laboratory balances are ideal for high-performance portfolio of both labs weighing hardware and software.

Supplier: AVIDITY SCIENCE

Puro™ III T and Geno™ II T are small in size; big on benefits. Providing RO or DI lab water to startup facilities.

Supplier: Bioss

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.

Supplier: Prosci

TMX2 is a single-pass type I membrane protein and contains 1 thioredoxin domain. Thioredoxin plays an important role in various cellular processes through redox regulation. The molecular cloning and characterization of one member of the thioredoxin superfamily, designated as TMX2.The TMX2 cDNA consists of 1644 nucleotides and contains an open reading frame encoding a protein of 372 amino acids with a predicted molecular mass of 42.5 kDa and an isoelectric point of 8.94. The TMX2 protein may possess an N-terminal signal peptide, a potential transmembrane domain, an Myb DNA-binding domain repeat signature, a thioredoxin consensus pattern, an endoplasmic reticulum (ER) membrane retention signal (KKXX-like motif), and a dileucine motif in the tail.

Supplier: Biotium

Nucleolin, Monoclonal antibody, Clone: 364-5 + NCL/902, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF405S, Immunogen: Lysate of SU-DHL-1 Nuclei (364-5); Recombinant human NCL protein (NCL/902), Synonyms: NCL; Nucl; Nucleolin; Protein C23, Size: 100uL

Supplier: ANTIBODIES.COM LLC

Human Pancreatic alpha Amylase ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human Pancreatic alpha Amylase in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: PIP

4-in-1 AR/FR ripstop jackets feature 8 pockets (shell: 2 chest patch, 1 sleeve pen, 2 waist patch, 1 interior; Liner: 2 waist slash, 1 sleeve pen) and an FR liner that can be worn alone or zipper into the outer shell.

Supplier: Mettler Toledo

With XPR micro balances we can able to weigh very small sample quantities directly into larger tare containers, with unrivalled accuracy up to 200 g.

Supplier: Prosci

ST14 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Supplier: HCL Label

As research laboratories and facility operations continue to implement plans to function safely under the current challenging pandemic conditions, it is essential to re-evaluate how to safely and effectively protect the lab workforce. HCL Labels provides visual products to help remind laboratory scientists and contractors of the requirements for access to the lab, and the necessary procedures to keep the work environment safe. HCL Labels is committed to helping organizations address the current health crisis by offering customizable products to help organizations protect the workforce.

Supplier: VWR International

Digital orbital shakers are designed for a wide range of applications such as solubility studies, extraction procedures, and cell cultures that require accurate and reproducible results.

Supplier: VWR International

Digital orbital shakers are designed for a wide range of applications including solubility studies, extraction procedures, and cell cultures that require accurate and reproducible results.

Supplier: VWR International

The VWR® Air Jacket CO₂ Incubator Basic delivers value and performance for everyday cell culture applications by providing a reliable growth environment with added convenience of on-demand high heat decontamination.

Supplier: Boster Biological Technology

Rabbit IgG polyclonal antibody for Ataxin-3(ATXN3) detection. Tested with WB, IHC-P, IHC-F, ICC, FCM in Human;Rat.

Supplier: Invitrogen

Thermo Scientific Pierce Fast Western Blot Kit, SuperSignal West Pico Substrate contains optimized reagents and protocol for picogram-level detection and and Western blot development less than 1 hour after gel transfer.

Supplier: Rockland Immunochemical

YPEL3 (yippee-like 3) belongs to a family of five yippee-like proteins, all of which localize to the centrosome or mitotic spindle and are widely expressed in both adult and fetal tissue. This localization plus the fact that the family of human YPEL proteins share a high degree of sequence homology across species suggests that these proteins may have a conserved function involved in cell division. YPEL3 is a p53-regulated gene whose expression is induced by DNA damage and in turn induces cellular senescence. It appears to function as a tumor suppressor as it is downregulated in colon and breast tumors.

Supplier: RESPONSE BIOMEDICAL CORP

The RAMP® Platform provides healthcare professionals with a choice of cardiac markers to optimize rapid clinical diagnosis. Using a compact, easy-to-use, automated reader, the RAMP® Platform delivers objective, rapid test results with an average time to result of approximately 15 minutes.

Supplier: Prosci

TNFRSF14 Antibody: Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-kappa B and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.

Supplier: Prosci

C-Type Lectin Domain Family 10 Member A (CLEC10A) is a type II transmembrane C-type lectin that is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. CLEC10A/MGL binds and internalizes molecules with terminal nonsialylated GalNAc carbohydrates such as the Tn carcinoma antigen. CLEC10A/MGL also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity. It constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. CLEC10A is thought to participate in the recognition of molecules from both altered self and pathogens due to its monosaccharide specificity for Gal and N-acetylgalactosamine (GalNAc). Human and rat carry a single gene for CLEC10A/MGL, while mouse has two closely related MGL1 and MGL2 genes.

Supplier: Biosensis

P75NTR Monoclonal antibody, Clone: MC192, Host: mouse, Reactivity: rat, Isotype: IgG1, Conjugate: ATTO 488, Immunogen:N-octyl glucoside solubilized proteins from isolated PC12 cell plasma membranes, Synonyms: NGF r

Supplier: VWR International

Digital orbital shakers are designed for a wide range of applications such as solubility studies, extraction procedures, and cell cultures that require accurate and reproducible results.