Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Bioss

Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf94 gene product has been provisionally designated C20orf94 pending further characterization.

Supplier: Bioss

Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf187 gene product has been provisionally designated C20orf187 pending further characterization.

Supplier: Rockland Immunochemical

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP11 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP11, it has been suggested that it has been associated with Crohn's disease.

Supplier: Genscript

A camelid single-domain antibody (sdAb, called Nanobody by Ablynx) is a peptide chain about 110 amino acids long comprising one variable domain of a heavy-chain antibody (VHH fragment). Like a whole antibody, a single-domain antibody is able to bind selectively to a specific antigen. Such antibodies allow a broad range of applications in biotechnical as well as therapeutic fields due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and cause anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Supplier: Genscript

GenScript MonoRab™ Rabbit Anti-Camelid VHH Antibody [HRP], mAb is specific for Camelid sdAb (Alpaca, Llama and Camel). The monoclonal antibody has no cross-reactivity with mouse, rat, rabbit, chicken, goat or human immunoglobulins.

Supplier: Invitrogen

RBS 35 Detergent Concentrate is a general cleaning agent for use on many laboratory surface materials and glassware, including lenses, mirrors, and reflectors.

Supplier: Prosci

Homeobox proteins are transcription factors notable for their ability to regulate embryogenesis. The reproductive homeobox proteins (Rhox) are expressed in a cell type-specific manner; several are hormonally regulated, and their expression pattern during postnatal testis development corresponds to their chromosomal position. Most of the Rhox proteins are expressed in Sertoli cells, the nurse cells in direct contact with developing male germ cells, suggesting that they regulate the expression of somatic-cell gene products critical for germ cell development.

Supplier: Prosci

CARMA1 Antibody: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the Ikappa K complex, thereby regulating activation of the NF-kappa B transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.

Supplier: Biotium

Preservative-free Annexin V conjugates are compatible with real-time staining of apoptotic cells for live cell imaging, fluorescence microscopy, or flow cytometry.

Supplier: SW Safety Solutions

When the situation calls for high performance, these neoprene gloves provide superior resistance to chemicals, punctures, and abrasions with a secure grip for handling small parts and slippery objects.

Supplier: Heidolph NA, LLC

These autoclaves have been designed to provide high quality repeatable performance and accountability for a wide range of applications used in modern laboratories,
which include:

Supplier: Eco Lab

The Bioquell L-4 is a mobile Hydrogen Peroxide Vapor bio-decontamination generator that can be connected to enclosures, equipment, isolators and more in your facility or, with additional accessories, be used for room/zone bio-decontamination.

Supplier: VWR International

Digital reciprocating shakers are designed for a wide range of applications including solubility studies, extraction procedures, and cell cultures that require accurate and reproducible results.

Supplier: AVANTOR PERFORMANCE MATERIALS US

J.T.Baker® Cell Lysis Solution Biotech Reagent is a cGMP pre-formulated and ready to use detergent optimized for the extraction and recovery of AAV particles from producer cell lines (HEK293 parental and suspension lines, SF9). J.T.Baker® Cell Lysis Solution is a proprietary blend of nonionic surfactants, free of octyl phenol ethoxylate, which demonstrates comparable performance industry standard detergents while addressing environmental concerns associated with REACH and downstream clearance concerns. Designed for Gene Therapy workflows, this formulation is easy to use and handle as it is ready-to-use, has low viscosity, does not require cold temperature shipping or storage, and is available in sizes to support processes from development to large scale commercial batches. Detail description provided in technical literature.

Supplier: Orflo

Moxi GO II™ combines two instruments to deliver amazingly affordable, easy to use, maintenance-free, gold standard cell count accuracy and precision through the Coulter Principle and integrating 2 channels of flow cytometry. This unique combination covers a large number of routine cell assays (cell count, cell volume, viability, cell proliferation, transfection checks, apoptosis, phenotyping, cellular response) with quantitative single cell data output.

Supplier: SARSTEDT INC

With our proven, high-quality tips you can expect maximum precision, sophisticated design and the highest purity. We guarantee highly transparent material, clear filling level rings and precise attachment of the pipette cone. The innovative and flexible refill system ensures resource-savings and reliability.

Supplier: Molecular Devices

FlexStation® 3 Benchtop Multi-Mode Microplate Reader combines Molecular Devices’ SpectraMax® M5e Multi-Mode Microplate Reader performance with an integrated 8- or 16-channel pipettor into one compact benchtop reader.

Supplier: Novus Biologicals

IL-33, also known as NF-HEV and DVS 27, is a 30 kDa proinflammatory protein that may also regulate gene transcription (1‑3).

Supplier: Novus Biologicals

IL-33, also known as NF-HEV and DVS 27, is a 30 kDa proinflammatory protein that may also regulate gene transcription (1‑3).

Supplier: ONSET COMPUTER CORPORATION

The InTemp CX402 VFCxxx is a bluetooth temperature data logger with a glycol bottle that monitors temperatures in refrigerators and freezers for clinics participating in the CDC vaccines for children program as well as hospitals, clinics, and WHO sites.

Supplier: Prosci

CARMA1 Antibody: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I kappa K complex, thereby regulating activation of the NF-kappa B transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.

Supplier: VWR International

VWR® Nano Spectrophotometer is designed to simplify and accelerate your molecular biology research and routine applications.

Supplier: Bioss

IQCF1 is an 81 amino acid protein encoded by the IQCF1 gene, which maps to human chromosome 3. Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

Supplier: Heidolph NA, LLC

Reciprocating shakers provide a back and forth motion for the vigorous mixing of separatory flasks and funnels in chemical applications

Supplier: SW Safety Solutions

Work with confidence in premium gloves that combine tactile sensitivity with trusted protection, in addition to EnerGel™ technology which soothes and hydrates skin.

Supplier: Prosci

PARP1 encodes a chromatin-associated enzyme, poly (ADP-ribosyl)transferase, which modifies various nuclear proteins by poly (ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. PARP1 can be cleaved resulting in fragements of 29 and 85 kDa.

Supplier: Rockland Immunochemical

CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the IkK complex, thereby regulating activation of the NF-kB transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.

Supplier: Prosci

MRE11 Antibody: MRE11 is involved in the repair of DNA double strand breaks as part of a complex that includes the Rad50 and NBS1 protein and is thought to act in the same pathway as the A-T mutated (ATM) protein. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for non-homologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Mutations in this protein result in a novel ataxia telangiectasia-like disorder (ATLD). Unlike the ATM protein, MRE11 is necessary proper mammalian development.

Supplier: Brady Worldwide

Optimize your operations with a Brady printer and scanner system. Get a printer, scanner and software kit - advanced tools that make workflows more seamless and boost productivity.