116946 Results for: "(5E)-5-[(2-Chloropyridin-3-yl)methylene]-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one"
L(+)-Lysine dihydrochloride, lyophilized powder for SILAC
Supplier: Invitrogen
Thermo Scientific Heavy and Light Amino Acids are used to specifically analyze protein expression by mass spectrometry using stable isotope labeling with amino acids in cell culture (SILAC) quantification kits.
Expand 1 Items
Aminex® Carbohydrate Analysis HPLC Columns, Bio-Rad
Supplier: Bio-Rad
Aminex® Carbohydrate Analysis HPLC Columns separate compounds using a combination of size exclusion and ligand exchange mechanisms.
Expand 9 Items
SpectraMax® iD3 Multi-Mode Microplate Reader, Molecular Devices
Supplier: Molecular Devices
Unparalleled performance on a personalized platform. The SpectraMax® iD3 Multi-Mode Microplate Reader is the cornerstone of a complete laboratory solution designed to expand the boundaries of research capabilities. With optimized reagents and the industry-leading data acquisition and analysis tool, SoftMax Pro® 7 Software, the SpectraMax® iD3 allows users to customize workflow to perfectly match their needs.
Expand 2 Items
NADP/NADPH-Glo Assay, Promega
Supplier: Promega Corporation
The NAD/NADH-Glo Assay is a bioluminescent, homogeneous single-reagent-addition assay for detecting total oxidized and reduced nicotinamide adenine dinucleotides and determining their ratio in biological samples or in defined enzyme reactions.
Expand 2 Items
DuPont™ Tychem® 10000 Encapsulated Level A Suits with EX Extra Wide Visor
Supplier: DuPont
Tychem® 10000 exhibits excellent chemical barrier properties and offers an extremely durable fabric that is puncture- and tear-resistant.
Expand 21 Items
Pierce™ Antibody Biotinylation Kit for IP, Thermo Scientific
Supplier: Invitrogen
The Thermo Scientific™ Pierce™ Antibody Biotinylation Kit for IP provides biotinylation reagents designed specifically for the labeling of primary antibodies used in immunoprecipitation applications.Optimized for IP—reagents and protocols developed specifically to address antibody labeling for immunoprecipitation applicationsEasy to use—kit configuration specifically optimized to accommodate 50–200 µg of antibody in a 100 µL reaction; desalting columns are provided to remove excess biotinylation reagent after labelingAmine reactive—reacts with primary amines (-NH2) of antibodiesEnhanced solubility—pegylation improves water solubility of the biotinylated antibody and prevents aggregation upon storageReduced steric hindrance—longer spacer arm (29 angstroms) minimize steric hindrance when binding to avidin moleculesThe Pierce Antibody Biotinylation Kit reagents have been optimized and validated to biotin label antibodies for IP and co-IP reactions
Expand 1 Items
Anti-IL7 Mouse Monoclonal Antibody [clone: NYR-hi7]
Supplier: Prosci
Iterleukin 7 is a lymphoid cell growth factor that affects pre-B, pro-B, and early T cells. IL-7 was previously known as pre-B cell growth factor and lymphopoietin 1. IL-7 supports the growth of early B cells from long-term lymphoid bone marrow cultures. It is mitogenic to thymocytes and enhances the response of cells to other stimuli such as polyhydroxyalkanoate (PHA) and concanavalin A (ConA). IL-7 stimulates the proliferation of CD4+/CD8+ cells. The proliferative response of thymocytes to IL-7 is not affected by antibodies to the T cell growth factors such as IL-2, IL-4 and IL-6, suggesting that IL-7 is capable of stimulating T cell proliferation through a pathway independent of the known T cell growth factors. Mature T cells respond to IL-7 and Con A, but not to IL-7 alone. In myeloid lineage cells, IL-7 upregulates the production of pro-inflammatory cytokines and stimulates the tumoricidal activity of monocytes/macrophages. IL-7 is expressed by adherent stromal cells from various tissues.
Expand 1 Items
pNL3.3[secNluc/minP] Vector, 20 µg, Promega
Supplier: Promega Corporation
The pNL1.3[secNluc], pNL3.3[secNluc/minP], pNL2.3[secNluc/Hygro] and pNL1.3.CMV[secNluc/CMV] Vectors offer a secreted small luciferase reporter in various promoter-driven or promoterless configurations for expression in mammalian cells.
Expand 1 Items
PMA™, PMAxx™, Real-Time PCR Viability Kit, Biotium
Supplier: Biotium
Viability PCR With PMA and PMAxx™ dyes
Expand 12 Items
Analytical Balances, Entris II Basic Advanced, Sartorius
Supplier: Sartorius
Entris® II Basic Advanced analytical balances feature isoCAL, intuitive graphic touch display and 13 built-in applications. Highly accurate results are guaranteed via the monolithic weigh cell technology. High chemical resistance is ensured by using parts made from hard-wearing PBT, stainless steel and glass. Integrated protection systems increase reliability of weighing results: 3 configurable levels determine valid weighing data and ensure only valid data is transferred to external devices.
Expand 7 Items
Manual Slim Pen Cutter With Safety Blade, Slice®
Supplier: SLICE, INC.
The Slice® Manual Slim Pen Cutter uses the same finger-friendly® blade as our original pen cutters, offering the same safety benefits. Slice’s proprietary grind—applied to advanced ceramics—creates a unique edge that’s safe to the touch and lasts up to 11 times longer than comparable metal blades. The slim handle style allows maneuverability in tight spaces and features a side slider for easier manipulation with the thumb. As with all Slice tools, it can be used ambidextrously. Made from durable glass-filled nylon, the Manual Slim Pen Cutter offers two different cutting depths to suit a variety of cutting tasks.
Expand 1 Items
Orion™ Versa Star Pro™ pH/ISE Benchtop Multiparameter Meter
Supplier: Thermo Fisher Scientific
Get premium performance and ultimate flexibility with the Orion™ Versa Star Pro™ Benchtop Multiparameter Meter with pH/ISE Module for pH, ion concentration, and temperature.
Expand 4 Items
Laboratory Glassware Washers, PLW 8616, Miele
Supplier: Miele
The PLW 8616 laboratory washer can accommodate 216 laboratory flasks, 588 vials, or 294 pipettes. The large glassware washer is flexible and simple to use, it has modular load carriers and SimpleLoad system. This efficient unit has a double door, 900 mm wide, a usable capacity of 351 litres. PLW 8616 provides reliable results, high pump performance with a variable-speed pump and features spray arm monitoring and a conductivity meter.
Expand 4 Items
FreeZone® Triad® Benchtop Freeze Dryers, Labconco®
Supplier: Labconco
FreeZone® Triad® Benchtop Freeze Dryers are designed for multiple types of lyophilization: flask, bulk and stoppering vials. With the ability to freeze dry samples in so many different forms, the Triad’s versatility and compact design make it perfect for busy labs. Now with Lyo-Works™ OS the Triad is smarter than ever, making freeze drying even challenging samples easy.
Expand 6 Items
pNL2.3[secNluc/Hygro] Vector, 20 µg, Promega
Supplier: Promega Corporation
The pNL1.3[secNluc], pNL3.3[secNluc/minP], pNL2.3[secNluc/Hygro] and pNL1.3.CMV[secNluc/CMV] Vectors offer a secreted small luciferase reporter in various promoter-driven or promoterless configurations for expression in mammalian cells.
Expand 1 Items
Human Proinsulin C-peptide (55-89)
Supplier: Anaspec Inc
Proinsulin C-peptide is the sequence of C peptide as it exists within proinsulin, the precursor to insulin which consists of insulin A chain, insulin B chain and C peptide (connecting peptide). In proinsulin, C peptide provides a means to ensure correct folding and assembly of the A and B chains. It is eventually cleaved away by proteases PC2, PC1/3 and CPE, at the flanking Arg-Arg and Lys-Arg basic residues (Arg-Arg-C peptide-Lys-Arg). Although C peptide is not present in mature insulin, it is stored in secretory granules, and eventually released into the bloodstream together with insulin in nearly equimolar amounts. Whereas insulin is metabolized quickly from circulation, C-peptide exhibits a slow turnover rate (>30 minutes). The measurement of the C-peptide is an important test for the β-cell function. In the red blood cells of type 2 diabetic patients, Na+,K+, ATPase activity is strongly related to blood C-peptide levels. C-peptide signal transduction in human renal tubular cells involves the activation of phospholipase C and PKC-δ and PKC-varepsilon, as well as RhoA, followed by phosphorylation of ERK1/2 and JNK and a parallel activation of Akt. C-peptide shows specific binding to a G-protein-coupled membrane binding site, resulting in Ca2+ influx, activation of mitogen-activated protein kinase signalling pathways and stimulation of Na+, K+ ATPase and endothelial nitric oxide synthase.
Sequence: RREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKR
MW: 3617 Da
% Peak area by HPLC: 95
Storage condition: -20° C
Expand 1 Items
pGL4.32[luc2P/NF-kappa-B-RE/Hygro] Vector, 20 µg, Promega
Supplier: Promega Corporation
pGL4.44[luc2P/AP1 RE/Hygro], pGL4.49[luc2P/TCF-LEF RE/Hygro], pGL4.29[luc2P/CRE/Hygro], pGL4.30[luc2P/NFAT-RE/Hygro], pGL4.32[luc2P/NF-κB-RE/Hygro], pGL4.33[luc2P/SRE/Hygro] and pGL4.34[luc2P/SRF-RE/Hygro] Vectors can explore various signaling pathways.
Expand 1 Items
Anti-INCENP Rabbit Polyclonal Antibody
Supplier: Genetex
Chromosomal passenger proteins are members of a group of proteins that move from centromeres to the spindle midzone during mitosis. INCENP (Inner Centromere Protein) is a chromosomal passenger protein with an essential role in mitosis and meiosis. It is a complex highly basic multidomain protein that is dynamically translocated from metaphase chromosomes to the spindle midzone during or just prior to anaphase. Some INCENP transfers to the equatorial cortex before formation of the cleavage furrow. Ultimately, it is discarded in the midbody at the completion of cytokinesis. INCENP, in complex with the passenger proteins aurora B kinase and survivin, acts at multiple points during mitosis. Studies in knockout mice established INCENP as essential for mouse development and viability. Loss of INCENP results in chromosome segregation defects and failures in cytokinesis. Targeting of survivin to its centromeric and central spindle locations during mitosis is dependent on INCENP. Direct binding of INCENP to beta tubulin has been demonstrated. Interactions of INCENP with heterochromatin protein HP1Hsa alpha and histone H2A.Z were also reported. INCENP levels are increased in several human cancer lines.
Expand 1 Items
Celestron StarSense Explorer DX 130AZ
Supplier: Celestron International
StarSense Explorer is ideal for beginners thanks to the app’s user-friendly interface and detailed tutorials.
Expand 1 Items
Entris® II Advanced Precision Laboratory Balances, Sartorius
Supplier: Sartorius
Entris® II Basic Advanced precision balances feature isoCAL, intuitive graphic touch display and 13 built-in applications. Highly accurate results are guaranteed via the monolithic weigh cell technology. High chemical resistance is ensured by using parts made from hard-wearing PBT, stainless steel and glass. Integrated protection systems increase reliability of weighing results: 3 configurable levels determine valid weighing data and ensure only valid data is transferred to external devices.
Expand 31 Items
Recombinant Human MMP-2 (from Mouse cells)
Supplier: MilliporeSigma
Recombinant, human pro-MMP-2 expressed in mouse cells. Useful for immunoblotting, substrate cleavage and assay zymography. The ~72 kDa purified proenzyme MMP-2 may be used as a positive control or standard for zymographic analysis, immunoblotting, or substrate cleavage assays. Requires activation prior to use. Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular processes such as angiogenesis, intimal hyperplasia, atherosclerosis and aneurysms. Recently, MMPs have been linked to neurodegenerative diseases such as Alzheimer′s, and amyotrophic lateral sclerosis (ALS). Natural inhibitors of MMPs, tissue inhibitor of matrix metalloproteinases (TIMPs) exist and synthetic inhibitors have been developed which offer hope of new treatment options for these diseases.
Expand 1 Items
pNL1.3[secNluc] Vector, 20 µg, Promega
Supplier: Promega Corporation
The pNL1.3[secNluc], pNL3.3[secNluc/minP], pNL2.3[secNluc/Hygro] and pNL1.3.CMV[secNluc/CMV] Vectors offer a secreted small luciferase reporter in various promoter-driven or promoterless configurations for expression in mammalian cells.
Expand 1 Items
Anti-IL4 Mouse Monoclonal Antibody [clone: 1.3_4F11-2G3]
Supplier: Prosci
IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Expand 1 Items
Monarch® gDNA Purification Columns, New England Biolabs
Supplier: New England Biolabs (NEB)
The Monarch® gDNA Purification Columns are a component of the Monarch® Genomic DNA Purification Kit (NEB #T3010) and can be used to purify up to 30 µg of DNA from a wide variety of biological samples.
Expand 1 Items
ADAMS™ A1C HA-8180V Analyzer, U.S. ARKRAY
Supplier: US ARKRAY, INC
Improve patient care with the ADAMS™ A1C HA-8180V. The easy-to-use, automated hemoglobin A1c analyzer with diagnosis claims employs gold standard HPLC technology. The analyzer builds on proven technology to generate quality results, improve outcomes and provide superior precision to accurately report HbA1c.
Expand 12 Items
DuPont™ Tychem® 10000 Encapsulated Level A Suits with Extra Wide Visor
Supplier: DuPont
Tychem® 10000 exhibits excellent chemical barrier properties and offers an extremely durable fabric that is puncture- and tear-resistant.
Expand 18 Items
Vector® M.O.M.™ Immunodetection Kits, Vector Laboratories
Supplier: Vector Laboratories
Vector® M.O.M.™ (Mouse on Mouse) Immunodetection Kits combine the flexibility and stability of avidin/biotin complex-based target protein detection with reagents that block interference from endogenous mouse IgG antibodies. Vector® M.O.M.™ ImmPRESS™ Kits combine the high sensitivity and simple protein detection protocol with reagents that block interference from endogenous mouse IgG antibodies.
Expand 5 Items
Anti-GABRA1 Rabbit Polyclonal Antibody
Supplier: Prosci
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function.
Expand 1 Items
Anti-GABRB3 Rabbit Polyclonal Antibody
Supplier: Prosci
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function.
Expand 1 Items
SP Scientific miVac Concentrator Packages, Genevac
Supplier: Genevac
miVac Centrifugal Evaporator Packages can be configured out of the box for maximum convenience.