51113 Results for: "(3-[1,2,4]Triazolo[4,3-a]pyridin-3-ylpropyl)amine+hydrochloride"

Supplier: Genetex

The two major cytoskeletal proteins implicated in cell motility are actin and myosin. Actin and myosin are constituents of many cell types and are involved in a myriad of cellular processes including locomotion, secretion, cytoplasmic streaming, phagocytosis and cytokinesis. Although actin is one of the most conserved eukaryotic proteins, it is expressed in mammals and birds as at least six isoforms characterized by electrophoresis and amino acid sequence analysis. Four of them represent the differentiation markers of muscle tissues and two are found in practically all cells.

Supplier: Rockland Immunochemical

ERK1 antibodies detect the ERK1 isoform. Mitogen activiated protein kinase 3, also known as MAPK3, ERK, or ERK1, is an integral component of the MAP kinase cascade that regulates cell growth and differentiation. ERK1 and ERK2 are activated by MEK1 and MEK2 in the B-raf signaling pathway resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Human ERK1 and ERK2 are 84% identical in sequence and share common functionality in cells. Anti-ERK1 antibody is ideal for investigators involved in Neuroscience, Cell Signaling and Cancer Research.

Supplier: Rockland Immunochemical

ERK1 antibodies detect the ERK1 isoform. Mitogen activiated protein kinase 3, also known as MAPK3, ERK, or ERK1, is an integral component of the MAP kinase cascade that regulates cell growth and differentiation. ERK1 and ERK2 are activated by MEK1 and MEK2 in the B-raf signaling pathway resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Human ERK1 and ERK2 are 84% identical in sequence and share common functionality in cells. Anti-ERK1 antibody is ideal for investigators involved in Neuroscience, Cell Signaling and Cancer Research.

Supplier: Rockland Immunochemical

ERK1 antibodies detect the ERK1 isoform. Mitogen activiated protein kinase 3, also known as MAPK3, ERK, or ERK1, is an integral component of the MAP kinase cascade that regulates cell growth and differentiation. ERK1 and ERK2 are activated by MEK1 and MEK2 in the B-raf signaling pathway resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Human ERK1 and ERK2 are 84% identical in sequence and share common functionality in cells. Anti-ERK1 antibody is ideal for investigators involved in Neuroscience, Cell Signaling and Cancer Research.

Supplier: Photovolt Instruments

The Photovolt Aquatest 2010 moisture analyzer provides rapid, accurate convenient low level moisture analysis from low ppm range to pure water with maximum isolation of solutions from atmospheric moisture

Supplier: Honeywell Research Chemicals

Original and Innovative Karl Fischer Reagents to analyze or measure water content

Supplier: BIOASSAY SYSTEMS

Homogeneous colorimetric assay for cell viability, proliferation, cytotoxcity and evaluation of anticancer agents.

Supplier: Invitrogen

The Imject™ EDC Carrier Protein Spin Kits enable effective one-step conjugation of a hapten to a carrier protein using EDC as the crosslinker. The resulting conjugate is used for eliciting an immune response and antibody production against the hapten.

Supplier: Cytiva

CNBr-activated Sepharose™ 4B is pre-activated media used for coupling antibodies or other large proteins containing -NH₂ groups to the Sepharose™ media, by the cyanogen bromide method, without an intermediate spacer arm.

Supplier: SARSTEDT INC

The high quality of blood samples collected with the S-Monovette® blood collection system is due to the gentle aspiration technique. It has been proven to significantly reduce hemolysis rates compared to vacuum systems. As a result, erythrocytes remain intact and blood collection does not have to be repeated as often.

Supplier: Cytiva

Ni Sepharose™ excel is an IMAC medium pre-charged with nickel ions very strongly bound to a chelating ligand. Samples that usually cause stripping of metal ions can, therefore, be loaded to the medium. Ni Sepharose™ excel is designed primarily for capture and purification of histidine-tagged proteins secreted into cell culture supernatants from eukaryotic cells such as insect cells or CHO cells.

Supplier: MilliporeSigma

Extran® AP 11 is a universal cleaning agent for the gentle cleaning of alkali-sensitive items. Cleaning of items which cannot be tainted with allergenic detergents, such as jewellery, glasses. A corrosion inhibitor is included for the intensive prevention of corrosion of glass and ceramics. Extran® AP 11 mild alkaline does not foam even during heavy agitation of the solution in a washing machine.

Supplier: Thermo Scientific Chemicals

50G

Supplier: Rockland Immunochemical

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

Supplier: Rockland Immunochemical

Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. A related family, termed the MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system.

Supplier: Invitrogen

Pierce™ Co-Immunoprecipitation (Co-IP) Kit provides covalent antibody immobilization and all the components necessary to perform a properly controlled co-IP experiment without antibody interference in the final product.

Supplier: Invitrogen

Thermo Scientific EZ-Link™ Desthiobiotinylation and Pull-down Kit is a complete set of reagents to biotin-label purified proteins and use them to purify interaction complexes using streptavidin agarose resin with mild elution conditions.

Supplier: Rockland Immunochemical

LSD1 (lysine specific demethylase 1) is a component of the histone demethylase complex that uses FAD as a prosthetic goup. LSD1 may have a dual effect on gene transcription. As it demethylates the mono- and dimethylated ‘Lys-4’ of histone H3, which are associated with transcriptional activation, LSD1 can act as a repressor of gene expression. However, LSD1 is also capable of demethylating ‘Lys-9’ of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to activation of androgen receptor target genes. LSD1 therefore is ideal for research in different processes such as Stem and Cancer Cell Biology, Embryonic Development, Epigenetics and Cell Differentiation and Proliferation.

Supplier: PHC Corporation

PHCbi's CytoGrow CO₂ incubator offers a high performance solution for mainstream cell culture applications in the research environment where precise control and contamination resistance are critical.

Supplier: Cytiva

DEAE Sepharose Fast Flow is a weak anion exchanger based on the well established Sepharose Fast Flow ion exchange platform, extensively used for preparative protein separations in both research and industrial applications.

Supplier: MP Biomedicals

MPure-12™ is a bench top automated system for rapid purification of nucleic acids from a wide variety of bio-specimens using magnetic bead separation technology. It has a uniquely designed magnetic bead processing chamber and is fully integrated with easy to use pre-packaged reagent kits.

Supplier: ADVANCED BIOMATRIX, INC. MS

Advanced BioMatrix products are recognized for purity, functionality, quality, and lot-to-lot consistency, allowing for reproducibility in research.

Supplier: Rockland Immunochemical

The founding member of the sirtuin protein family was the silent information regulator 2 protein (Sir2p) of Saccharomyces cervisiae, an NAD+-dependent histone deacetylase (HDAC) that regulates chromatin silencing. The SIR2 family of genes are highly conserved from prokaryotes to eukaryotes. Mammals have seven homologs of Sir2p, SIRT1-7, which are involved in diverse processes ranging from transcriptional regulation, cell cycle progression and DNA-damage repair to aging. SIRT2 is a predominantly cytoplasmic protein that colocalizes with microtubules and can deacetylate alpha-tubulin and regulate progression through the cell cycle. Most Sirtuins are highly expressed in brain and testis, while Sirt2 expression is higher in fetal relative to adult brain. Recent studies on SIRT2 support the therapeutic utility of inhibitors for the treatment of neurodegenerative diseases such as Parkinson's disease.

Supplier: Epredia

The CryoStar™ NX50 Cryostat extends the benefits of the NX series by offering an innovative new look at cryosectioning. The NX series has been designed completely around the user to deliver optimal sectioning quality, unmatched ergonomics, and safety in an energy efficient package. With the NX series, users can deliver high quality results comfortably, safely, and efficiently.

Supplier: CUBE BIOTECH

The HisCube His-tag protein purification MINI kit is our way to supply your laboratory with a convenient method for high-quality, small-scale His-tag protein purifications. We put all of our experience in His-tag purifications into this Kit to provide a protocol that is easy to follow.

Supplier: Prosci

ABP1 is a membrane glycoprotein that is expressed in many epithelium-rich and/or hematopoietic tissues and oxidatively deaminates putrescine and histamine. The protein may play a role in controlling the level of histamine and/or putrescine in these tissues. It also binds to and is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.This gene encodes a membrane glycoprotein that is expressed in many epithelium-rich and/or hematopoietic tissues and oxidatively deaminates putrescine and histamine. The protein may play a role in controlling the level of histamine and/or putrescine in these tissues. It also binds to and is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.

Supplier: Cytiva

Epoxy-activated Sepharose™ 6B is a pre-activated medium for immobilisation of various ligands including sugars through coupling of hydroxy, amino or thiol groups on the ligand to Sepharose™ 6B via a 12-atom hydrophilic spacer arm. Medium is formed by reacting Sepharose™ 6B with 1,4-bis (2,3- epoxy-propoxy-) butane. It can be used to couple sugars and other carbohydrates via stable ether linkages to hydroxyl groups.

Supplier: ADVANCED BIOMATRIX, INC. MS

Advanced BioMatrix products are recognized for purity, functionality, quality, and lot-to-lot consistency, allowing for reproducibility in research.

Supplier: Labconco

Logic Class II, Type A2 Biosafety Cabinets (BSCs) offer comprehensive personnel, product and environmental protection from hazardous particulates, including risk group agents requiring BSL 1 to 4 containment. These cabinets are ideal for applications involving biological hazards, genetic material, antineoplastic drugs and other hazardous airborne particulates. All models ensure the highest standard of safety and performance.

Supplier: G-Biosciences

G-Biosciences' HOOK™ Cell Surface Protein Isolation kit uses our HOOK™ biotin labeling and purification technology in conjunction with our Mammalian Cell PE LB™ lysis buffer to conveniently label cell surface proteins and isolate them for further analysis, including Western blotting