Danusertib ≥95%
Irritant- Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
- Return Policy
Product Details & Documents
Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC(50) values for the Aurora kinases all under 100nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC(50) values ranging from 20nM for A2780 cells to 200nM.
- CAS Number:827318-97-8
- Formula:C₂₆H₃₀N₆O₃
- MDL Number:MFCD12024692
- Molecular Weight:474.6 g/mol
- Storage Temperature:Freezer
Specifications
Specification Test Results
- Purity:95%
- Appearance/Color:Solid.
- Solubility:Soluble in DMSO or ethanol.
Specifications
- Pack type:Plastic vial
- Size:10 mg
Specifications
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