Rapamycin ≥98%
Product Details & Documents
Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor and inhibits lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells.
- White powder
This antibiotic also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity
This rapamycin binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.
Angiogenesis inhibition is also exhibited, possibly through the inhibition of the Akt pathway. It also induces autophagy in yeast and mammalian cell lines.
Extinction coefficients: E1 %, 1 cm (maximum wavelength, 95% ethanol): 417 (267 nm); 541 (277 nm); 416 (288 nm)
Soluble in ether, chloroform, acetone,DMF, methanol (25 mg/mL - clear, colorless solution) or DMSO, very sparingly soluble in hexane and petr ether and insoluble in water
- CAS Number:53123-88-9
- Formula:C₅₁H₇₉NO₁₃
- MDL Number:MFCD00867594
- Molecular Weight:914.19 g/mol
- Storage Temperature:Freezer
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- Size:100 µg
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