IL-15 is a widely expressed proinflammatory cytokine that is structurally and functionally related to IL-2. Signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. Regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function.
High quality
- Low endotoxin
- Lot-to-lot consistency
- Animal free
- Manufactured following GMP guidelines
Dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. Combines with other common γ chain cytokines (IL-2, IL-7 and IL-21) to promote favorable anti-tumoral phenotypes in adoptive cellular therapies such as CAR-T cell therapy. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.
Host cell protein: ≤30 ng/ml, host cell DNA: ≤0.01 ng/ml, sterility testing: No growth, mycoplasma: Negative
For research use or further manufacturing only.
- Conjugation:Unconjugated
- Protein Function:Cytokine
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:At or below –20 °C
- Endotoxin Content:Endotoxin LAL (EU/µg) ≤0.05
- Biological Activity:Bioactivity assay: Proliferation of CTLL-2 ; ED50 ≤1 ng/ml; Bioactivity ≥ 2×10⁴ IU/µg
- Gene ID:P40933
- Reconstitution Instructions:Sterile water at 0.1 - 0.5 mg/ml
- Endotoxin-free:N
- Carrier-Free:Y
- Protease-free:N
- Animal-Free:Y
- Protein Synonyms:IL-T
- Protein/Peptide Name:IL-15
- Purity:≥97%
- Molecular Weight:12.9 kDa
- Sequence:MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS
- Endotoxin Level:Low
- Formulation:10 mM sodium bicarbonate, pH 8.5
- Nuclease-free:N
- Grade:GMP
- Shipping Temperature:Ambient