Human Recombinant FOLLISTATIN (from E. coli)
Supplier: VWR International
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About this item
Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin. Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-β) family members, such as activin, bone morphogenetic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-β1. Follistatin functions as an antagonist by binding TGF-β family members to block interaction with their signaling receptors. Follistatin also inhibits the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary.
High quality
Low endotoxin
Affordable
Caution: For research use only.
Specifications
- Conjugation:Unconjugated
- Protein Function:Cytokine
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:–20 °C
- Endotoxin Content:Endotoxin LAL (EU/µg) ≤0.1
- Biological Activity:Bioactivity assay: Neutralization of human activin A induced cytotoxicity of MPC-11 cells; ED50 ≤200 ng/ml; Bioactivity ≥5.0×10³ units/mg
- Gene ID:P19883
- Reconstitution Instructions:Sterile water at 0.1 mg/ml
- Endotoxin-free:N
- Carrier-Free:Y
- Protease-free:N
- Animal-Free:N
- Protein Synonyms:FS|activin-binding protein|FSH-suppressing protein (FSP)
- Protein/Peptide Name:FOLLISTATIN
- Purity:≥95%
- Molecular Weight:31.7 kDa
- Sequence:MGNCWLRQAK NGRCQVLYKT ELSKEECCST GRLSTSWTEE DVNDNTLFKW MIFNGGAPNC IPCKETCENV DCGPGKKCRMNKKNKPRCVC APDCSNITWK GPVCGLDGKT YRNECALLKA RCKEQPELEV QYQGRCKKTC RDVFCPGSST CVVDQTNNAY CVTCNRICPEPASSEQYLCG NDGVTYSSAC HLRKATCLLG RSIGLAYEGK CIKAKSCEDI QCTGGKKCLW DFKVGRGRCS LCDELCPDSK SDEPVCASDNATYASECAMK EAACSSGVLL EVKHSGSCN
- Endotoxin Level:Low
- Formulation:10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5
- Nuclease-free:N
- Grade:RUO
- Shipping Temperature:RT
- Tested Applications:Bioassay