Optimix C18/C8 HPLC Columns, Bonna-Agela Technologies

Conventional silica based HPLC stationary phases are usually bonded with mono-type alkyl chain molecules, such as C18, C8, and more.

• Metal Impurity: <30 ppm
• Pore Size: 100 Å
• Double End-capping

Optimix C18/C8 HPLC columns provide improved selectivity for stereo isomers, better differentiation of shapes, and better peak shape due to uniformity of the bonding. The balanced hydrophilicity and hydrophobicity enable extended retention for polar compounds, and non-excessive retention for strong hydrophobic compounds.

Recent studies have revealed that synergistic effects can be obtained when the bonded surface consists of C18 mixed with a shorter chain such as C8, amide, or nitro-phenyl, etc. These new products offer different selectivity, coordinating multi-functionality, as well as a spacer effect (C18/C8). It is difficult to produce a uniformly bonded C18 surface on silica due to steric hindrance of the bulky C18 chain. This problem can be easily overcome when the surface is bonded with mixed chain lengths, C18, and a shorter silane.

As a result, there are many advantages, such as improved surface uniformity, better penetration of molecules during partitioning due to less steric hindrance, and different selectivity compared to a mono-chain type stationary phase. As one of the leaders in separation technologies, Bonna-Agela Technologies has innovatively developed a family of non-ionic, mixed phase HPLC/SFC columns.