Epic HILIC-HC (HC for high capacity) is composed of a polyhydroxylated polymer coated and bound to silica.

This composition provides hydroxyl levels that are well above conventional hydroxyl and diol type stationary phases. Many of the commercially stationary phases used for HILIC chromatography are converted normal phase columns. These normal phase columns yield poor methods, poor separations and lack durability. Epic HILIC-HC is specifically designed for HILIC chromatography and can achieve high performance separations, yield rugged methods and deliver long column life times.

The chromatogram shown below highlights the unique capability for Epic HILIC-HC, in this chromatogram toluene is less retained than uracil. Uracil has been traditionally used as a unretained maker for the determination of void volume, however with Epic HILIC-HC and an 80% acetonitrile mobile phase uracil can be retained.