Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor with broad production across different cell types.

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The regulation of monocyte and macrophage development to maintain homeostasis is primarily governed by M-CSF, which is generated by stromal cells present in both the bloodstream and tissues.
Mature mononuclear phagocytes, in response, possess CSF-1 receptors (CSF-1R) and eliminate circulating CSF-1.
This process creates a feedback mechanism responsible for diminishing monocyte proliferation (2, 3, 4).
M-CSF also exerts its effects by interacting with CSF1R, influencing various processes related to immunology, bone health, fertility, and pregnancy regulation.
Human M-CSF has cross reactivity to mouse cells, whereas mouse M-CSF does not exhibit activity on human cells.

Host Cell Protein: ≤30 ng/ml
Host Cell DNA: ≤0.01 ng/ml
Sterility testing: No Growth
Mycoplasma: Negative