This assay has high sensitivity and excellent specificity for detecting Mouse Kim1 (Kidney Injury Molecule 1). The assay range is from 39 to 2,500 pg/ml (Sandwich kit) with a sensitivity of 14 pg/ml. There is no detectable cross-reactivity with other relevant proteins. Activity loss rate and accelerated stability test ect have been conducted to guarantee the best performance of the products after long storage and delivery.

• High sensitivity and specificity
• Perfect reproducibility and consistency across batches
• Quality control with three-level inspections
• Wide range of targets/species available
• Intra-assay: CV<10%; Inter-assay: CV<12%

kidney injury molecule-1 (KIM-1) is a type 1 transmembrane protein that is not detectable in normal kidney tissue but is expressed at high levels in rodent kidneys with dedifferentiated proximal tubule epithelial cells after ischemic or toxic injury. Sequence analysis predicted that the 359-amino acid type I HAVCR1 glycoprotein, which is 79% identical to the monkey protein, contains a signal sequence; a 109-amino acid cys-rich N-terminal region with only 1 conserved N-glycosylation site; a 163-amino acid TSP-rich region with 3 N-glycosylation sites, 2 of which are conserved; and a 48-amino acid intracellular domain, 12 residues shorter than that of the monkey protein. Northern blot analysis revealed ubiquitous expression of a 4.4-kb HAVCR1 transcript, with highest levels in kidney and testis.