- Assay duration:Multiple steps
- Assay Type (ELISA with LOV):Competitive
- Conjugate ELISA:Biotin
- Format:Pre-coated
- Host:Rabbit
- Primary antibody reactivity:Mouse
- Target protein:CGRP
- Size:1 kit
- Sample Type:Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids
- Cross Reactivity:No significant cross-reactivity or interference between Calcitonin Gene Related Peptide (CGRP) and analogues was observed
- Detection Method:Colorimetric
- Time to Results:2 h
- Shelf Life:12 Months
- Detection Range:12.35 - 1000 pg/ml
- Storage Temperature:4 °C for one month (frequent use), −20 °C for one year
- Sample Volume:50 µl
- Sensitivity:4.94 pg/ml
- Regulatory Status:RUO
- Cat. No.:MSPP-CEA876MU
- No. of tests:96 wells
This assay has high sensitivity and excellent specificity for detecting Mouse CGRP (Calcitonin Gene Related Peptide). The assay range is from 12.35 to 1000 pg/ml (Competitive kit) with a sensitivity of 4.94 pg/ml. There is no detectable cross-reactivity with other relevant proteins. Activity loss rate and accelerated stability test ect have been conducted to guarantee the best performance of the products after long storage and delivery.
- High sensitivity and specificity
- Perfect reproducibility and consistency across batches
- Quality control with three-level inspections
- Wide range of targets/species available
- Intra-assay: CV<10%; Inter-assay: CV<12%
CGRP is an important cutaneous neuropeptide. It is widely expressed in both the central and peripheral nervous system. CGRP is known as pro inflammatory factor and is thought to be involved in neurogenic inflammation. It was reported that CGRP stimulate the adhesiveness of human umbilical vein endothelial cells for monocytic cell line and neutrophils.The function of CGRP in skin remains unclear. However, evidences suggested that it may be directly involved in modulating the functions of keratinocytes, Langerhans cells and microvascular endothelial cells in the skin.On the other hand, psoriasis is generally known as inflammatory and proliferative skin disorder. In psoriatic plaque lesion there are epidermal influx of polymorphonulear leukocytes, and the presence of mononuclear infiltration in the papillary dermis and in the epidermis.