Specifications
- Assay duration:Multiple steps
- Assay Type (ELISA with LOV):Competitive
- Conjugate ELISA:Biotin
- Format:Pre-coated
- Host:Rabbit
- Primary antibody reactivity:Multiple
- Target protein:QA
- Size:1 kit
- Sample Type:Serum, plasma and other biological fluids
- Cross Reactivity:No significant cross-reactivity or interference between Quinolinic Acid (QA) and analogues was observed
- Detection Method:Colorimetric
- Time to Results:2 h
- Shelf Life:12 Months
- Detection Range:1.23 - 100 ng/ml
- Storage Temperature:4 °C for one month (frequent use), −20 °C for one year
- Sample Volume:50 µl
- Sensitivity:0.60 ng/ml
- Regulatory Status:RUO
- Cat. No.:MSPP-CEK552GE
- No. of tests:96 wells
Specifications
About this item
This assay has high sensitivity and excellent specificity for detecting General species QA (Quinolinic Acid). The assay range is from 1.23 to 100 ng/ml (Competitive kit) with a sensitivity of 0.60 ng/ml. There is no detectable cross-reactivity with other relevant proteins. Activity loss rate and accelerated stability test ect have been conducted to guarantee the best performance of the products after long storage and delivery.
- High sensitivity and specificity
- Perfect reproducibility and consistency across batches
- Quality control with three-level inspections
- Wide range of targets/species available
- Intra-assay: CV<10%; Inter-assay: CV<12%
Quinolinic acid is a dicarboxylic acid with a pyridine backbone. It may be prepared by the oxidation of quinoline.Quinolinic acid is a downstream product of the kynurenine pathway, which metabolizes the amino acid tryptophan. It acts as an NMDA receptor agonist. Quinolinic acid has a potent neurotoxic effect. Studies have demonstrated that quinolinic acid may be involved in many psychiatric disorders, neurodegenerative processes in the brain, as well as other disorders. Within the brain, quinolinic acid is only produced by activated microglia and macrophages. Quinolinic acid is a byproduct of the kynurenine pathway, which is responsible for catabolism of tryptophan in mammals. Quinolinic acid is unable to pass through the blood-brain barrier (BBB) and must be produced within the brain microglial cells or macrophages that have passed the BBB.